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DND1 encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression.
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DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4 (zeige CCR4 Proteine)-NOT deadenylase complex.
DND1 interacts with NANOS2 (zeige NANOS2 Proteine) to load unique RNAs into the CCR4 (zeige CCR4 Proteine)-NOTdeaden complex; this interaction is mediated by the zinc finger domain of NANOS2 (zeige NANOS2 Proteine), which is essential for its association with target RNAs; DND1 is an essential partner for NANOS2 (zeige NANOS2 Proteine) that leads to the degradation of specific RNAs in male germ cell development
Dnd1 heterozygotes, lower oxygen availability was associated with metabolic differences
APOBEC3G (zeige APOBEC3G Proteine) inhibits DND1 function to regulate microRNA activity.
results show that Dnd1 is essential for normal allelic inheritance and that Dnd1Ter has a novel combination of functions that significantly increase risk for both testicular and intestinal cancer
DND1 is the first protein known to have an RNA recognition motif directly implicated as a heritable cause of spontaneous tumorigenesis
DND1-alpha isoform to be necessary for germ cell viability and its loss in Ter (zeige TECR Proteine) mice results in germ cell depletion, germ cell tumor development and partial embryonic lethality in the 129 strain.
The role of dead-end in germ-cell tumor development.
The interaction of DND1 and APOBEC3 could be one mechanism for maintaining viability of germ cells and for preventing germ cell tumor development
when Dnd1(Ter/Ter) XX germ cells developed in a testicular environment they gave rise to the same neoplastic clusters as mutant XY germ cells in a testis.
Mechanistically, Dnd1 could bind to 3'-UTR of LATS2, the key kinase of Hippo pathway, thus elevating LATS2 mRNA stability and its expression, subsequently leading to phosphorylation of YAP (zeige YAP1 Proteine) and its cytoplasmic retention.
Dnd1 facilitates apoptosis by increasing the expression of Bim via its competitive combining with miR-221 in Bim-3'UTR.
RBM38 (zeige RBM38 Proteine) and DND1 are repressed in primary acute myeloid leukemia (zeige BCL11A Proteine), neutrophil differentiation is dependent on increased expression of both proteins, and they have a role in regulating p21(CIP1 (zeige CDKN1A Proteine)) expression during acute promyelocytic leukemia (zeige PML Proteine) differentiation
The increased sensitivity of transformed keratinocytes to miR (zeige MLXIP Proteine)-21's effects occurs in part through downregulation of the RNA-binding protein (zeige PTBP1 Proteine) DND1 during the transformation process.
Results suggest that DND1 may impose another level of translational regulation to modulate expression of critical factors in ES cells.
We conclude that germline DND1 mutations are unlikely to contribute significantly to human testicular germ cell tumor susceptibility
Cloning of zebrafish dnd1 and identification of human DND1 by database analysis.
Unravels a novel role of Dnd1 in protecting certain mRNAs from miRNA-mediated repression.
MiR (zeige MLXIP Proteine)-24 up-regulation reduced the expression of RNA-binding protein (zeige PTBP1 Proteine) dead end 1 (zeige VPS11 Proteine) (DND1). Knockdown of miR (zeige MLXIP Proteine)-24 led to enhanced expression of DND1.
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17.
dead end homolog 1
, dead end homolog 1 (zebrafish)
, dead end protein homolog 1-like
, dead end protein homolog 1
, RNA-binding motif, single-stranded-interacting protein 4