anti-DNA Methyltransferase 3A (DNMT3A) Antikörper

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Zusätzlich bieten wir Ihnen DNMT3A Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DNMT3A 13435 O88508
DNMT3A 444984 Q1LZ53
DNMT3A    
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Top anti-DNMT3A Antikörper auf antikoerper-online.de

Showing 10 out of 10 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Huhn Unkonjugiert ELISA, WB   50 μg Anmelden zum Anzeigen 11 bis 16 Tage
$579.86
Details
Maus Maus Unkonjugiert IF, IHC, WB   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$645.86
Details
Maus Maus Unkonjugiert WB   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$592.43
Details
Human Kaninchen Unkonjugiert IP, ELISA, WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$572.00
Details
Human Kaninchen Unkonjugiert   50 μL Anmelden zum Anzeigen 11 bis 16 Tage
$369.55
Details
Human Kaninchen Unkonjugiert IP, WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$570.43
Details
Human Kaninchen HRP   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Kaninchen Biotin   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
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Human Kaninchen FITC   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Kaninchen Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details

DNMT3A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine)
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Rat (Rattus)

Human
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Weitere Antikörper gegen DNMT3A Interaktionspartner

Mouse (Murine) DNA Methyltransferase 3A (DNMT3A) Interaktionspartner

  1. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a null and DNA methyltransferase 1/DNA methyltransferase (zeige DNMT1 Antikörper) 3a null mice.

  2. This is attributed in part to ineffective repression of Tcf1 (zeige HNF1A Antikörper) expression in knockout T cells, as DNMT3a localizes to the Tcf7 (zeige TCF7 Antikörper) promoter and catalyzes its de novo methylation in early effector WT CD8 (zeige CD8A Antikörper)(+) T cells. These data identify DNMT3a as a crucial regulator of CD8 (zeige CD8A Antikörper)(+) early effector cell differentiation and effector versus memory fate decisions.

  3. Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation (zeige HELLS Antikörper) activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner.

  4. Study shows that in the mouse brain during early life, the DNA methyltransferase (zeige DNMT1 Antikörper) DNMT3A preferentially binds transiently to intergenic regions and across transcribed regions of lowly expressed genes and that this binding primarily determines the pattern of DNA methylation (zeige HELLS Antikörper) at CA sequences in the adult brain.

  5. conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor

  6. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  7. Loss of DNMT3A expression is associated with development of malignancy.

  8. confirm the transformation potential of DNMT3A(R882H) Tet2 (zeige TET2 Antikörper)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (zeige TET2 Antikörper) inactivation driving lymphoid malignancies

  9. overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (zeige TFAP2A Antikörper) knockdown.

  10. These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.

DNMT3A Antigen-Profil

Protein Überblick

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA methyltransferase 3A (Dnmt3a) Antikörper
  • DNA methyltransferase 3 alpha (Dnmt3a) Antikörper
  • MmuIIIA Antikörper

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5)-methyltransferase 3A , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA , DNA methyltransferase 3A

GENE ID SPEZIES
13435 Mus musculus
444984 Rattus norvegicus
Ausgewählte Anbieter für anti-DNMT3A (DNMT3A) Antikörper
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