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This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Zusätzlich bieten wir Ihnen DNMT3A Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor
These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.
Loss of DNMT3A expression is associated with development of malignancy.
confirm the transformation potential of DNMT3A(R882H) Tet2 (zeige TET2 Antikörper)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (zeige TET2 Antikörper) inactivation driving lymphoid malignancies
overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (zeige TFAP2A Antikörper) knockdown.
These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.
in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.
Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (zeige FLT3 Antikörper) gene (Flt3 (zeige FLT3 Antikörper)(ITD)) and the nucleophosmin (zeige NPM1 Antikörper) gene (Npm1 (zeige GJA1 Antikörper)(c)) to induce AML (zeige RUNX1 Antikörper) in vivo, and promoted resistance to anthracycline chemotherapy.
miR (zeige MLXIP Antikörper)-29a/b/c repressed DNMT3A expression by directly targeting its 3' untranslated region (3' UTR (zeige UTS2R Antikörper)). Our data reveal a novel mechanism of miR (zeige MLXIP Antikörper)-29a/b/c in the regulation of adipogenesis
DOT1L (zeige DOT1L Antikörper) may play a critical role in DNMT3A-mutant leukemia.
This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed.
DNA (cytosine-5)-methyltransferase 3A
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA
, DNA methyltransferase 3A