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DMAP1 encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. Zusätzlich bieten wir Ihnen DNA Methyltransferase 1-Associated Protein 1 Proteine (4) und DNA Methyltransferase 1-Associated Protein 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal DMAP1 Primary Antibody für IHC (p), ELISA - ABIN565960
Yamaguchi, Takenobu, Ohira, Nakazawa, Yoshida, Akita, Shimozato, Iwama, Nakagawara, Kamijo: Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. in European journal of cancer (Oxford, England : 1990) 2014
A novel tumour suppressor gene, MDGA2 (zeige MDGA2 Antikörper), which is frequently inactivated by promoter methylation in Gastric cancer, exerts a tumour suppressive function by cooperating with DMAP1 to activate the p53 (zeige TP53 Antikörper)/p21 (zeige CDKN1A Antikörper) signalling cascade.
Targeted knockdown of human DNA methyltransferase 1 (zeige DNMT1 Antikörper) expression restores the expression levels of tumor suppressor genes, thus inhibiting the proliferation of cholangiocarcinoma cell line cells.
These results suggest that DMAP1 is a critical regulator of ATM (zeige ATM Antikörper) activity and function
positive staining for DNMT1 (zeige DNMT1 Antikörper) in clinical cancer specimens was significantly linked to lower rates of response to treatments and shorter survival of patients with pharyngeal cancer.
Knocking down DMAP1 caused hypomethylation of the DNA repair products.
MMTR is an intrinsic negative cell cycle regulator (zeige CDKN2A Antikörper) that modulates the CAK (zeige CCNH Antikörper) kinase activity via interaction with MAT1 (zeige MAT1A Antikörper).
RGS6 (zeige RGS6 Antikörper) inhibited the transcriptional repressor activity of DMAP1.
Localization of DNA methyltransferase-1 (zeige DNMT1 Antikörper) during oocyte differentiation, in vitro maturation and early embryonic development in cow.(
Consistent with the phenotypes of loss of other members of the TIP60 (zeige KAT5 Antikörper)-p400 (zeige ITPR1 Antikörper) complex, Dmap1(-/-) mice died during preimplantation in both Dnmt1 (zeige DNMT1 Antikörper)(+/+) and Dnmt1 (zeige DNMT1 Antikörper)(V)(/)(V) backgrounds.
Dmap1 plays a crucial role in DNA repair, and is indispensable for the maintenance of chromosomal integrity
In this study, two-hybrid screening leads to the identification of DNMT1 (zeige DNMT1 Antikörper) associated protein, DMAP1, as a Daax-interacting protein.
Findings suggest that Bmi1 (zeige BMI1 Antikörper) incorporates Dmap1 in polycomb (zeige CBX2 Antikörper) gene silencing.
Data suggest that MAT1-mediated transcriptional repressor (MMTR) is part of the basic cellular machinery for a wide range of transcriptional regulation via interaction with TFIIH (zeige GTF2H4 Antikörper) and HDAC1 (zeige HDAC1 Antikörper).
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
DNA methyltransferase 1-associated protein DMAP1
, DNA methyltransferase 1-associated protein 1
, DNA methyltransferase 1 associated protein 1
, DNMT1 associated protein 1
, DNMT1-associated protein 1
, DNMT1 associated protein-1
, MAT1-mediated transcriptional repressor