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HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008]..
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HELQ plays an important role in regulating the expression of DNA repair proteins NER (zeige NR1H2 Antikörper) pathway which, in turn, contributes to cellular response to cisplatin and patients' response to platinum-based chemotherapy.
WHD domain may contribute to ssDNA translocation, resulting in DNA helicase activity or in removal of other DNA bound proteins by "reeling" ssDNA.
HELQ regulates the CHK1 (zeige CHEK1 Antikörper)-RAD51 (zeige RAD51 Antikörper) signaling pathway in osteosarcoma cells.
Our results indicate that HELQ is not a major breast and ovarian cancer susceptibility gene in the Finnish population
No mutation was identified. Our study indicates for the first time that mutations in the coding sequence of the HELQ gene may not be responsible for premature ovarian failure in Chinese Han population.
Single nucleotide polymorphism in the HELQ gene is associated with upper aerodigestive tract cancers.
HELQ is associated with the RAD51 paralogs RAD51B/C/D and XRCC2, and with the DNA damage-responsive kinase ATR.
one role for HEL308 at sites of blocked replication might be to open up the parental strands to facilitate the loading of subsequent factors required for replication restart.
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308
identification of homolog to POLN
The findings suggest that HELQ contributes to genome stability in unchallenged conditions through a mechanism distinct from the function of FANCC (zeige FANCC Antikörper).
results reveal a critical role for HELQ in replication-coupled DNA repair, germ cell maintenance and tumour suppression in mammals
HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002
DNA helicase HEL308
, POLQ-like helicase
, helicase POLQ-like
, mus308-like helicase
, DNA helicase Hel308
, helicase, mus308-like