DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Proteine (DCLRE1B)

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. Zusätzlich bieten wir Ihnen DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Antikörper (38) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DCLRE1B 64858 Q9H816
DCLRE1B 310745 Q4KLY6
DCLRE1B 140917 Q8C7W7
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Top DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,545.67
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DCLRE1B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Rat (Rattus)

Mouse (Murine)

Weitere Proteine zu DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Interaktionspartnern

Human DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Interaktionspartner

  1. Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B.

  2. The SNM1B/APOLLO DNA nuclease (zeige DCLRE1C Proteine) functions in resolution of replication stress and maintenance of common fragile site stability.

  3. the N-terminal region of Snm1B forms a complex containing PSF2 (zeige TAP2 Proteine) and Mus81 (zeige MUS81 Proteine), while the C-terminal region is important for PSF2 (zeige TAP2 Proteine)-mediated chromatin association.

  4. The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.

  5. differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles

  6. SNM1B functions epistatically to the central Fanconi anemia factor, FANCD2, in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks

  7. TRF2 (zeige TERF2 Proteine), which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1 (zeige TOP1 Proteine), TOP2alpha, and TOP2beta (zeige TOP2B Proteine) at telomeres.

  8. siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair

  9. the C terminus of Snm1B was shown to interact with the TRF (zeige IL5 Proteine) homology domain of TRF2 (zeige TERF2 Proteine) indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 (zeige TERF2 Proteine)

  10. SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease (zeige EXO1 Proteine) activity and functions together with TRF2 (zeige TERF2 Proteine) to protect telomeres from damage and fusion.

Mouse (Murine) DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Interaktionspartner

  1. Study documents the combinatorial action of Apollo, POT1b, CST (zeige CORT Proteine), and the 5' exonuclease (zeige EXO1 Proteine) Exo1 (zeige EXO1 Proteine) in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.

  2. The telomeric protein (zeige SYCE1 Proteine) SNM1B/Apollo is required for normal cell proliferation and embryonic development

  3. TRF2 (zeige TERF2 Proteine)-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM (zeige ATM Proteine) signaling, and protecting leading-end telomeres from fusion.

  4. Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.

DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) (DCLRE1B) Protein Überblick

Protein Überblick

DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000

Genbezeichner und Symbole assoziert mit DCLRE1B

  • DNA cross-link repair 1B (DCLRE1B)
  • DNA cross-link repair 1B (Dclre1b)
  • DNA cross-link repair 1B (dclre1b)
  • AI452214 Protein
  • Apollo Protein
  • im:6894074 Protein
  • mSNM1B Protein
  • SNM1B Protein
  • SNMIB Protein
  • zgc:154089 Protein

Bezeichner auf Proteinebene für DCLRE1B

5' exonuclease Apollo , DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) , PSO2 homolog , SNM1 homolog B , DNA cross-link repair 1B protein

GENE ID SPEZIES
64858 Homo sapiens
428269 Gallus gallus
310745 Rattus norvegicus
768137 Danio rerio
140917 Mus musculus
Ausgewählte Anbieter für DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Proteine (DCLRE1B)
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