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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. Zusätzlich bieten wir Ihnen DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Antikörper (38) und und viele weitere Produktgruppen zu diesem Protein an.
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Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B.
The SNM1B/APOLLO DNA nuclease (zeige DCLRE1C Proteine) functions in resolution of replication stress and maintenance of common fragile site stability.
the N-terminal region of Snm1B forms a complex containing PSF2 (zeige TAP2 Proteine) and Mus81 (zeige MUS81 Proteine), while the C-terminal region is important for PSF2 (zeige TAP2 Proteine)-mediated chromatin association.
The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.
differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles
SNM1B functions epistatically to the central Fanconi anemia factor, FANCD2, in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks
TRF2 (zeige TERF2 Proteine), which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1 (zeige TOP1 Proteine), TOP2alpha, and TOP2beta (zeige TOP2B Proteine) at telomeres.
siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair
the C terminus of Snm1B was shown to interact with the TRF (zeige IL5 Proteine) homology domain of TRF2 (zeige TERF2 Proteine) indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 (zeige TERF2 Proteine)
SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease (zeige EXO1 Proteine) activity and functions together with TRF2 (zeige TERF2 Proteine) to protect telomeres from damage and fusion.
Study documents the combinatorial action of Apollo, POT1b, CST (zeige CORT Proteine), and the 5' exonuclease (zeige EXO1 Proteine) Exo1 (zeige EXO1 Proteine) in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
The telomeric protein (zeige SYCE1 Proteine) SNM1B/Apollo is required for normal cell proliferation and embryonic development
TRF2 (zeige TERF2 Proteine)-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM (zeige ATM Proteine) signaling, and protecting leading-end telomeres from fusion.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000
5' exonuclease Apollo
, DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)
, PSO2 homolog
, SNM1 homolog B
, DNA cross-link repair 1B protein