anti-DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Antikörper

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human DNMT3A DNMT3A 1788 Q9Y6K1
Anti-Ratte DNMT3A DNMT3A 444984 Q1LZ53
Anti-Maus DNMT3A DNMT3A 13435 O88508
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Top anti-DNMT3A Antikörper auf antikoerper-online.de

Showing 10 out of 279 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ChIP, CyTOF, FACS, ICC, IF, IHC (p), IHC (wm), WB Western blot analysis for Dnmt3a using ABIN266067 at 2 ug/ml against 10 ?g of 293 cell lysate transfected with either mouse Dnmt3a (lane A) or mouse Dnmt3b (lane B). Immuno-staining of Dnmt3a using ABIN266067 at 5 ug/ml dilution on cultured HeLa cells. The nucleic staining is shown in most of the cells. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-Dnmt3a Pab (ABIN387881) in T47-D cell lysate. Dnmt3a (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Lysates from thymus tissue after radiation were subjected to WB using antibody against DNMT3a. CT, control animals. FR, animals subjected to fractionated exposure. AC, acutely exposed animals. All sample loading was normalized to protein content. Representative Western blots from three independent experiments are shown. each lane represents a protein extract of a thymus of one animal. (Mol. Cancer Res. 2005 Oct 01.3(10):553-561) 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human liver cancer tumor cells (nuclear) (52 year old female) Immunohistochemistry-Paraffin: DNMT3A Antibody [NBP1-85961] - Staining of human testis shows nuclear positivity in Leydig cells and cells in seminiferous ducts (46 year old male) 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$275.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host:  Rabbit  Target Name:  DNMT3A  Sample Type:  Lung Tumor lysates  Antibody Dilution:  1.0ug/ml Host:  Mouse  Target Name:  DNMT3A  Sample Tissue:  Mouse Spleen  Antibody Dilution:  1ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), IP, IHC, WB Western blot analysis using ABIN151733 to detect overexpressed DNMT3A level in HCT-116 cells. Lane 1: 40 ug of nuclear extract from untreated HCT-116 cells. Lane 2: 40 ug of Nuclear extract from HCT-116 cells overexpressing DNMT3A. Immunohistochemistry: Dnmt3a Antibody [ABIN151733] - Dnmt3a antibody was tested in human testis using DAB with hematoxylin counterstain. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details
Human Maus Unkonjugiert ChIP, WB DNMT3A mAb tested by Western blot. Detection of DNMT3A by Western blot. The analysis was performed using DNMT3A mAb at a 2 µg/ml dilution and whole-cell extracts from 293 cells that had been transfected with plasmid expressing either mouse DNMT3A (lane A) or DNMT3B (lane B). 100 μg Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-DNMT3A Antibody (Center D472) (ABIN387882) in Jurkat cell line lysates (35 µg/lane).DNMT3A(arrow) was detected using the purified polyclonal antibody (1:60dilution). Formalin-fixed and paraffin-embedded human kidney tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Maus Kaninchen Unkonjugiert IHC, WB DNMT3A antibody (pAb) tested by Western blot. Nuclear extract (30 µg) of mouse ES cells probed with DNMT3A antibody at a dilution of 1:500. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$495.83
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded human gastric carcinoma labeled with Anti-Dnmt3a Polyclonal Antibody, Unconjugated (ABIN669336) at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$318.45
Details

Am meisten referenzierte anti-DNMT3A Antikörper

  1. Human Monoclonal DNMT3A Primary Antibody für ChIP, CyTOF - ABIN266067 : Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002 (PubMed)
    Show all 84 Pubmed References

  2. Human Polyclonal DNMT3A Primary Antibody für ICC, IF - ABIN151733 : Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003 (PubMed)
    Show all 11 Pubmed References

  3. Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387881 : Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999 (PubMed)
    Show all 12 Pubmed References

  4. Human Monoclonal DNMT3A Primary Antibody für ChIP, WB - ABIN2668262 : Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. in Biochemical pharmacology 2011 (PubMed)
    Show all 3 Pubmed References

  5. Human Polyclonal DNMT3A Primary Antibody für IF (p), IHC (p) - ABIN669336 : Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015 (PubMed)
    Show all 2 Pubmed References

  6. Mouse (Murine) Polyclonal DNMT3A Primary Antibody für IHC, WB - ABIN2668264 : Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. in Nature neuroscience 2015 (PubMed)
    Show all 2 Pubmed References

  7. Human Monoclonal DNMT3A Primary Antibody für FACS, ICC - ABIN252483 : Sato, Kondo, Arai: The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. in Biochemical and biophysical research communications 2006 (PubMed)

  8. Human Polyclonal DNMT3A Primary Antibody für WB - ABIN2668283 : Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. in Nature communications 2011 (PubMed)

  9. Human Monoclonal DNMT3A Primary Antibody für ICC, IF - ABIN2668287 : Felle, Joppien, Németh, Diermeier, Thalhammer, Dobner, Kremmer, Kappler, Längst: The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1. in Nucleic acids research 2011 (PubMed)

  10. Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387882 : Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen DNMT3A Interaktionspartner

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a, Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Low frequency of DNMT3A mutations in pediatric T-ALL is in striking contrast to adult T-ALL and renders the necessity for the search of other candidate prognostic markers. Combined Sanger sequencing-HRM approach offers a cost-effective option for genotyping DNMT3A coding sequence, with potential clinical application in other hematological malignancies.

  2. 2.65-angstrom crystal structure of the DNMT3A-DNMT3L (zeige TRDMT1 Antikörper)-DNA complex in which two DNMT3A monomers simultaneously attack two cytosine-phosphate-guanine (CpG) dinucleotides, with the target sites separated by 14 base pairs within the same DNA duplex; mechanistic basis for DNMT3A-mediated DNA methylation (zeige HELLS Antikörper) and establishment of its aetiological link to human disease

  3. based on the investigation of previously reported variants in patients with Tatton-Brown-Rahman syndrome , we found overlap in the spectrum of DNMT3A variants observed in this disorder and somatic variants in hematological malignancies

  4. The emodininduced downregulation of UHRF1 (zeige UHRF1 Antikörper) led to an increase in the level of DNA methyltransferase 3A.

  5. Data suggest that miR (zeige MLXIP Antikörper)-200b-3p may exhibit targeting and suppressive effects on DNA methyltransferase 3A (DNMT3A).

  6. Prostaglandin E2 promotes the acquisition of DNMT3A-dependent tolerogenic functions in human myeloid-derived suppressor cells.

  7. human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase (zeige DNMT1 Antikörper) DNMT3A and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L (zeige DOT1L Antikörper).

  8. the immunohistochemical expressions of Klotho (zeige KL Antikörper) and DNMT3a in tissues obtained from oral dysplasia and oral squamous cell carcinoma, is reported.

  9. this epigenetic antagonism precedes malignant transformation and can be observed in preleukemic LSK (zeige LCK Antikörper) cells from Idh2 (zeige IDH2 Antikörper)(R140Q) or Dnmt3a(R882H) single-mutant and Idh2 (zeige IDH2 Antikörper)(R140Q)/Dnmt3a(R882H) double-mutant mice. IDH (zeige IDH1 Antikörper)/DNMT3A double-mutant acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper))manifested upregulation of a RAS signaling signature and displayed unique sensitivity to MEK (zeige MAP2K1 Antikörper) inhibition ex vivo as compared with AMLs with either single mutation.

  10. The current findings confirmed that downregulation of DNMT3A protein expression and the ensuing disturbance of the maintenance DNA methylation (zeige HELLS Antikörper) may serve an important role in the pathogenesis of early embryo growth arrest.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Antikörper) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The effect of p53 (zeige TP53 Antikörper) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Antikörper) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (zeige DNMT3B Antikörper) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaktionspartner

  1. The aim of the present study is to investigate spatial and temporal expression levels and subcellular localizations of the DNMT1 (zeige DNMT1 Antikörper), DNMT3A, and DNMT3B (zeige DNMT3B Antikörper) proteins in the mouse germinal vesicle (GV) and metaphase II (MII) oocytes, and early embryos from 1-cell to blastocyst stages.

  2. our Dnmt3a R878H mice have shown that leukemic cells have altered gene expression and epigenetic regulatory patterns contributing to the growth/survival advantage over WT mice.The present study found that the DNMT3A mutation contributed to hypomethylation in the gene body region of mTOR (zeige FRAP1 Antikörper) in Dnmt3aR878H/WT mice.

  3. Knockdown of DNMT3A or DNMT1 (zeige DNMT1 Antikörper) protected neurons against mutant Htt (zeige HTT Antikörper)-induced toxicity, together demonstrating a requirement for DNMTs in mutant Htt (zeige HTT Antikörper)-triggered neuronal death and suggesting a neurodegenerative mechanism based on DNA methylation (zeige HELLS Antikörper)-mediated transcriptional repression.

  4. Data demonstrate that DNMT3A and DNA methylation (zeige HELLS Antikörper) are key modulators of mast cell responsiveness to acute and chronic stimulation.

  5. These data suggest that DNMT3a is required for nerve injury-induced and MBD1 (zeige DPEP1 Antikörper)-mediated epigenetic silencing of the MOR (zeige OPRM1 Antikörper) and KOR (zeige OPRK1 Antikörper) in the injured DRG. DNMT3a inhibition may serve as a promising adjuvant therapy for opioid use in neuropathic pain management.

  6. Data show that conditional deletion of Dnmt3a and simultaneous "knock in" of Flt3ITD/+, cooperate to drive leukemia development at a faster rate than Dnmt3a loss alone.

  7. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  8. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (zeige DNMT3B Antikörper) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (zeige PPARG Antikörper).

  9. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a null and DNA methyltransferase 1/DNA methyltransferase (zeige DNMT1 Antikörper) 3a null mice.

  10. This is attributed in part to ineffective repression of Tcf1 (zeige HNF1A Antikörper) expression in knockout T cells, as DNMT3a localizes to the Tcf7 (zeige TCF7 Antikörper) promoter and catalyzes its de novo methylation in early effector WT CD8 (zeige CD8A Antikörper)(+) T cells. These data identify DNMT3a as a crucial regulator of CD8 (zeige CD8A Antikörper)(+) early effector cell differentiation and effector versus memory fate decisions.

DNMT3A Antigen-Profil

Protein Überblick

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A) Antikörper
  • DNA methyltransferase 3 alpha (dnmt3a) Antikörper
  • DNA methyltransferase 3 alpha (Dnmt3a) Antikörper
  • DNA methyltransferase 3A (Dnmt3a) Antikörper
  • DNMT3A Antikörper
  • DNMT3A2 Antikörper
  • M.HsaIIIA Antikörper
  • MmuIIIA Antikörper

Bezeichner auf Proteinebene für DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPEZIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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