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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Zusätzlich bieten wir Ihnen DNMT3A Proteine (6) und DNMT3A Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 272 products:
Human Monoclonal DNMT3A Primary Antibody für ChIP, CyTOF - ABIN266067
Chen, Ueda, Xie, Li: A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. in The Journal of biological chemistry 2002
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Human Polyclonal DNMT3A Primary Antibody für ICC, IF - ABIN151733
Robert, Morin, Beaulieu, Gauthier, Chute, Barsalou, MacLeod: DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. in Nature genetics 2003
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Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387881
Xie, Wang, Okano, Nogami, Li, He, Okumura, Li: Cloning, expression and chromosome locations of the human DNMT3 gene family. in Gene 1999
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Human Monoclonal DNMT3A Primary Antibody für ChIP, WB - ABIN2668262
Karius, Schnekenburger, Ghelfi, Walter, Dicato, Diederich: Reversible epigenetic fingerprint-mediated glutathione-S-transferase P1 gene silencing in human leukemia cell lines. in Biochemical pharmacology 2011
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Human Polyclonal DNMT3A Primary Antibody für IF (p), IHC (p) - ABIN669336
Zhao, Hou, Chen, Shao, Zhu, Bu, Gu, Li, Zhang, Du, Fu, Kong, Luo, Long, Li, Deng, Zhao, Cen: Prenatal cocaine exposure impairs cognitive function of progeny via insulin growth factor II epigenetic regulation. in Neurobiology of disease 2015
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Mouse (Murine) Polyclonal DNMT3A Primary Antibody für IHC, WB - ABIN2668264
Tognini, Napoli, Tola, Silingardi, Della Ragione, DEsposito, Pizzorusso: Experience-dependent DNA methylation regulates plasticity in the developing visual cortex. in Nature neuroscience 2015
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Human Monoclonal DNMT3A Primary Antibody für FACS, ICC - ABIN252483
Sato, Kondo, Arai: The orphan nuclear receptor GCNF recruits DNA methyltransferase for Oct-3/4 silencing. in Biochemical and biophysical research communications 2006
Human Polyclonal DNMT3A Primary Antibody für WB - ABIN387865
ODoherty, OShea, Fair: Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins. in Biology of reproduction 2012
Human Polyclonal DNMT3A Primary Antibody für IHC (p), WB - ABIN387882
Robertson, Uzvolgyi, Liang, Talmadge, Sumegi, Gonzales, Jones: The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors. in Nucleic acids research 1999
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Human Polyclonal DNMT3A Primary Antibody für WB - ABIN2668283
Chang, Sun, Kokura, Horton, Fukuda, Espejo, Izumi, Koomen, Bedford, Zhang, Shinkai, Fang, Cheng: MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. in Nature communications 2011
Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (zeige DNMT1 Antikörper), Dnmt3a, Hdac1 (zeige HDAC1 Antikörper), Kdm3a (zeige KDM3A Antikörper) and Uhrf1 (zeige UHRF1 Antikörper) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).
this study shows that DNMT3A mutations are present in a significant proportion of SF3B1mut patients with RARS (zeige RARS Antikörper) and its presence has a clearly negative impact on outcomes, determining a higher RBC (zeige CACNA1C Antikörper) transfusion dependency, higher risk of progression to AML (zeige RUNX1 Antikörper), and lower OS.
DNMT1 (zeige DNMT1 Antikörper), DNMT3A, and DNMT3B (zeige DNMT3B Antikörper) were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (zeige DNMT1 Antikörper) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (zeige DNMT1 Antikörper) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (zeige DNMT1 Antikörper) A201G gene polymorphi
genetic variations in STX1B (zeige STX1B Antikörper), DNMT3A and CYP1A1 (zeige CYP1A1 Antikörper) have roles in influencing warfarin maintenance dose
DNMT3A is a de novo DNA methyltransferase (zeige DNMT1 Antikörper) that has recently gained relevance because of its frequent mutation in a large variety of immature and mature hematologic neoplasms. DNMT3A mutations are early events during cancer development and seem to confer poor prognosis to acute myeloid leukemia (zeige BCL11A Antikörper) patients making this gene an attractive target for new therapies. [review]
the present cohort study demonstrated that FLT3 (zeige FLT3 Antikörper)-ITD and DNMT3A R882 double mutation predicts poor prognosis in Chinese AML (zeige RUNX1 Antikörper) patients receiving chemotherapy or allo-HSCT treatment.
propose a model of the DNMT3A PWWP domain-H3K36me3 complex and build a model of DNMT3A (PWWP-ADD-CD) in a nucleosomal context
Variability in placental telomere length is associated with alterations in DNAm at TERT (zeige TERT Antikörper), DNMT1 (zeige DNMT1 Antikörper), and DNMT3a.
Dnmt1 (zeige DNMT1 Antikörper) and Dnmt3a are critical regulators for epigenetic silencing of endothelial cell marker genes.
DNMT3 mutation in OCI-AML3 (zeige RUNX2 Antikörper) strain enhances leukemic aggressiveness by promoting extramedullary infiltration process, which is partially through upregulating TWIST1 (zeige TWIST1 Antikörper).
Concurrent STAT3 (zeige STAT3 Antikörper), DNMT3A, and TET2 (zeige TET2 Antikörper) mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential
Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (zeige HELLS Antikörper) content are rather a function of time, and not a genetic component.
The effect of p53 (zeige TP53 Antikörper) expression on the development of cloned embryos, and its interaction with HDAC1 (zeige HDAC1 Antikörper) and DNMT3A are reported.
The expression levels of DNMT3a and DNMT3b (zeige DNMT3B Antikörper) were associated with several beef quality traits.
Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation (zeige HELLS Antikörper) activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner.
Study shows that in the mouse brain during early life, the DNA methyltransferase (zeige DNMT1 Antikörper) DNMT3A preferentially binds transiently to intergenic regions and across transcribed regions of lowly expressed genes and that this binding primarily determines the pattern of DNA methylation (zeige HELLS Antikörper) at CA sequences in the adult brain.
conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor
These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.
Loss of DNMT3A expression is associated with development of malignancy.
confirm the transformation potential of DNMT3A(R882H) Tet2 (zeige TET2 Antikörper)(-/-) progenitors and represent the first cooperative model in mice involving Tet2 (zeige TET2 Antikörper) inactivation driving lymphoid malignancies
overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2alpha (zeige TFAP2A Antikörper) knockdown.
These data show that DNMT3a plays an important role in regulating embryonic cardiomyocyte gene expression, morphology and function.
in addition to the established role of Dnmt3a in regulating self-renewal, Dnmt3a regulates tissue tropism and limits myeloid progenitor expansion in vivo.
Dnmt3a mutations induced hematopoietic stem cell expansion, cooperated with mutations in the FMS-like tyrosine kinase 3 (zeige FLT3 Antikörper) gene (Flt3 (zeige FLT3 Antikörper)(ITD)) and the nucleophosmin (zeige NPM1 Antikörper) gene (Npm1 (zeige GJA1 Antikörper)(c)) to induce AML (zeige RUNX1 Antikörper) in vivo, and promoted resistance to anthracycline chemotherapy.
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
DNA (cytosine-5-)-methyltransferase 3 alpha
, DNA cytosine methyltransferase 3 alpha
, DNA (cytosine-5)-methyltransferase 3A
, DNA methyl transferase alpha
, DNA methyltransferase 3A
, DNA MTase HsaIIIA
, DNA cytosine methyltransferase 3A2
, DNA-methyltransferase 3a
, DNA MTase MmuIIIA
, DNA methyltransferase MmuIIIA