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DCAF7 encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes.
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these findings reveal an indirect role for Wdr68 in the BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of dlx1a/2a.
we show that while a GFP-Wdr68 fusion functionally substituted for craniofacial development in the zebrafish, that a Nuclear Export Signal (NES (zeige NES Proteine)) fusion protein (GFPNESWdr68) failed to support craniofacial development
The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 (zeige DYRK1A Proteine) protein complexes.
Immunoprecipitation and pulldown experiments identified DCAF7 as an adaptor for the association of the adenovirus E1A (zeige BCKDHA Proteine) protein with DYRK1A (zeige DYRK1A Proteine) and HIPK2 (zeige HIPK2 Proteine)
knockdown of DCAF7 reduced the degradation of DNA ligase I (zeige LIG1 Proteine) in response to inhibition of proliferation and replacement of ubiquitylated lysine residues reduced the in vitro ubiquitylation of DNA ligase I (zeige LIG1 Proteine) by Cul4-DDB1 and DCAF7. In contrast, a different E3 ubiquitin ligase (zeige MUL1 Proteine) regulates FEN-1 (zeige FEN1 Proteine) turnover.
results demonstrate that the molecular chaperone (zeige HSP90AA1 Proteine) TRiC/CCT (zeige TCP1 Proteine) is essential for correct protein folding, DYRK1A (zeige DYRK1A Proteine) binding, and nuclear accumulation of WDR68.
DYRK1A (zeige DYRK1A Proteine) binds specifically to WDR68 in cells; the binding, but not the phosphorylation event, induces the nuclear translocation of WDR68.
Han11 was required to allow coupling of MEKK1 (zeige MAP3K1 Proteine) to DYRK1 (zeige DYRK1A Proteine) and HIPK2 (zeige HIPK2 Proteine).
that AN11 may be a physiological regulator of GLI1 (zeige GLI1 Proteine) transcriptional activity
Depleting Huntingtin-associated protein 1 (Hap1 (zeige HAP1 Proteine)) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (zeige DYRK1A Proteine))-DDB1 and CUL4 associated factor 7 (Dcaf7) interaction and increased the DYRK1A (zeige DYRK1A Proteine) protein level.
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signalling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants.
DDB1- and CUL4-associated factor 7
, dirty south
, AN11 homolog
, WD repeat domain 68
, DDB1 and CUL4 associated factor 7
, WD-repeat protein
, WD repeat-containing protein 68
, WD repeat-containing protein An11 homolog
, human anthocyanin
, seven-WD-repeat protein of the AN11 family-1