DAN Domain Family, Member 5 Proteine (DAND5)

DAND5 encodes a member of the BMP (bone morphogenic protein) antagonist family. Zusätzlich bieten wir Ihnen DAND5 Antikörper (62) und DAND5 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DAND5 199699 Q8N907
DAND5 23863 Q76LW6
DAND5 594864  
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,480.50
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Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,486.00
Details

DAND5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Xenopus laevis

Weitere Proteine zu DAN Domain Family, Member 5 (DAND5) Interaktionspartnern

Human DAN Domain Family, Member 5 (DAND5) Interaktionspartner

  1. High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer.

  2. In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy

  3. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta (zeige TGFB1 Proteine) ligands, induces dormant breast cancer cells to undergo reactivation in the lung.

Xenopus laevis DAN Domain Family, Member 5 (DAND5) Interaktionspartner

  1. Coco binds to TGFbeta1 (zeige TGFB1 Proteine) and enhances TGFbeta1 (zeige TGFB1 Proteine) binding to its receptor Alk5 (zeige TGFBR1 Proteine) thus acting as both an inhibitor and an enhancer of signaling, depending on the ligand it binds.

  2. Coco required to prevent Activin and Nodal signals in dorsal marginal side of embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus embryo

  3. Data suggest that Coco acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline.

  4. Coco directly inhibits derriere (zeige GDF3 Proteine) and Xnr1 (zeige NODAL Proteine), and with them define a posttranscriptionally regulated signaling center which is a necessary link in the signaling chain leading to an increased TGF-beta (zeige TGFB1 Proteine) signal on the left side of the embryo.

Mouse (Murine) DAN Domain Family, Member 5 (DAND5) Interaktionspartner

  1. Cerl2 plays an important role during heart development.

  2. The consequent prolonged Nodal activity in the node by the absence of Cerl2 affects local Nodal expression and prolongs its expression in the lateral plate mesoderm.

  3. Decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt (zeige WNT2 Proteine)-Cerl2 interlinked feedback loops.

  4. Study shows the cilia protein Arl13b (zeige ARL13B Proteine) is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.

  5. Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side

  6. cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.

DAND5 Protein Überblick

Protein Überblick

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Genbezeichner und Symbole assoziert mit DAND5

  • DAN domain BMP antagonist family member 5 (DAND5)
  • DAN domain family member 5, BMP antagonist S homeolog (dand5.S)
  • DAN domain family member 5, BMP antagonist (Dand5)
  • 51-B6 Protein
  • cer2 Protein
  • Cerl-2 Protein
  • cerl2 Protein
  • Cerr2 Protein
  • cktsf1b3 Protein
  • coco Protein
  • crl2 Protein
  • dante Protein
  • Dte Protein
  • grem3 Protein
  • SP1 Protein
  • xCoco Protein

Bezeichner auf Proteinebene für DAND5

DAN domain family member 5 , DAN domain family, member 5 , cerberus 2 , cerberus-like 2 , cerberus-like protein 2 , cerl-2 , cysteine knot superfamily 1, BMP antagonist 3 , gremlin-3 , cerberus-like 2 protein , dante

GENE ID SPEZIES
199699 Homo sapiens
594864 Xenopus laevis
23863 Mus musculus
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