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Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation. Zusätzlich bieten wir Ihnen CPEB3 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that the expression of cytoplasmic polyadenylation element binding protein 3 (CPEB3) positively correlated with tumor progression and malignancy but negatively correlated with protein phosphorylation in the alternatively spliced region.
Expression of miR (zeige MLXIP Antikörper)-26a and miR (zeige MLXIP Antikörper)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (zeige ADAMTS7 Antikörper), ATP1B1 (zeige ATP1B1 Antikörper), COL4A2 (zeige COL4a2 Antikörper), CPEB3, CDK6 (zeige CDK6 Antikörper), DNMT3a (zeige DNMT3A Antikörper) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Data show that EGF receptor (EGFR (zeige EGFR Antikörper)) is involved in the microRNA miR (zeige MLXIP Antikörper)-107 pathogenesis of hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) through cytoplasmic polyadenylation element binding protein 3 (CPEB3).
Data suggest that the RNA recognition motif (RRM) domain of CPEB3 (as a soluble peptide fragment) exhibits protein conformation distinct from those of the canonical RRM domain.
cleavage of CPEB3 by NMDA-activated calpain 2 (zeige CAPN2 Antikörper) accounts for the activity-related translation of CPEB3-targeted RNAs
Together, these results indicate that Tob (zeige TDO2 Antikörper) mediates the recruitment of Caf1 (zeige CHAF1B Antikörper) to the target of CPEB3 and elicits deadenylation and decay of the mRNA.
Secondary structure determination and native gel analyses reveal that the cleaved population of the CPEB3 ribozyme has a single, secondary structure that closely resembles the HDV ribozyme
isolation of a ribozyme conserved mammalian sequence that resides in an intron of the CPEB3 gene
Topological regulation of synaptic AMPA (zeige GRIA3 Antikörper) receptor expression by the RNA-binding protein CPEB3 has been demonstrated.
CPEB3-regulated translation of TRPV1 (zeige TRPV1 Antikörper) RNA may play a role in fine-tuning thermal sensitivity of nociceptors.
CPEB3 is SUMOylated in hippocampal neurons. CPEB3 regulates SUMO-2 (zeige SUMO2 Antikörper) translation.
CPEB3 interacts with the actin cytoskeleton in yeast and at mouse synapses. CPEB3 is a functional prion (zeige PRNP Antikörper) with a tripartite prion (zeige PRNP Antikörper) domain architecture.
The main finding of our study is that CPEB3-mediated protein synthesis is required for long-term hippocampal-based memory storage.
Cpeb3 null mice exhibited enhanced short-term fear memory and translationally elevated PSD95 (zeige DLG4 Antikörper), NMDA receptors and GluA1 (zeige GRIA1 Antikörper).
These results suggest a model whereby Neuralized1-dependent ubiquitination facilitates hippocampal plasticity and hippocampal-dependent memory storage by modulating the activity of CPEB3 and CPEB3-dependent protein synthesis and synapse formation.
CPEB3 has a novel function in the nucleus as to suppress Stat5b (zeige STAT5B Antikörper)-dependent EGFR (zeige EGFR Antikörper) gene transcription
show that CPEB3 expression is increased in a time-dependent manner during the course of postnatal development, and CPEB3 is localized mostly in the inner retina, including retinal ganglion cells.
Inhibits differentiation of intermediate mesoderm from an early stage to inhibit pronephric differentiation but induce neural differentiation.
cytoplasmic polyadenylation element-binding protein 3
, CPE-binding protein 3
, cytoplasmic polyadenylation element binding protein 3
, cytoplasmatic polyadenylation element binding protein 3