anti-Cystinosis, Nephropathic (CTNS) Antikörper

CTNS encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Zusätzlich bieten wir Ihnen CTNS Proteine (9) und CTNS Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CTNS 1497 O60931
CTNS 287478  
CTNS 83429 P57757
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Top anti-CTNS Antikörper auf antikoerper-online.de

Showing 10 out of 45 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: Ctns Sample Type: Mouse Lung lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert ELISA, WB CTNS monoclonal antibody (M09), clone 5G6 Western Blot analysis of CTNS expression in HepG2. Detection limit for recombinant GST tagged CTNS is approximately 0.3 ng/mL as a capture antibody. 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Maus Unkonjugiert ELISA, WB CTNS monoclonal antibody (M09), clone 5G6. Western Blot analysis of CTNS expression in HepG2. Detection limit for recombinant GST tagged CTNS is approximately 0.3ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB CTNS Antibody (C-term) (ABIN1881240) western blot analysis in HepG2 cell line lysates (35 µg/lane). This demonstrates the CTNS antibody detected the CTNS protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: CTNS Antibody [NBP1-02469] - Staining of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 25 ug/ml. 0.05 mg Anmelden zum Anzeigen 10 bis 13 Tage
$556.31
Details
Human Maus Unkonjugiert ELISA, IHC, IHC (p), WB Anti-CTNS / Cystinosin antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$550.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p) 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IF/ICC, WB Western blot analysis of extracts of various cell lines, using CTNS antibody (ABIN5974151) at 1/1000 dilution. Immunofluorescence analysis of HeLa cells using CTNS antibody (ABIN5974151). Blue: DAPI for nuclear staining. 100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$426.40
Details
Human Kaninchen Unkonjugiert IF, WB Western blot analysis of extracts of various cell lines, using CTNS antibody. Immunofluorescence analysis of HeLa cells using CTNS antibody. 120 μL Anmelden zum Anzeigen 12 bis 14 Tage
$251.90
Details
Human Kaninchen Unkonjugiert WB Western Blot analysis of CTNS expression in transfected 293T cell line by CTNS MaxPab polyclonal antibody.<br><br>Lane 1: CTNS transfected lysate(45.10 KDa).<br>Lane 2: Non-transfected lysate.<br> CTNS MaxPab rabbit polyclonal antibody. Western Blot analysis of CTNS expression in human stomach. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$425.71
Details

Am meisten referenzierte anti-CTNS Antikörper

  1. Human Polyclonal CTNS Primary Antibody für WB - ABIN1881240 : Taranta, Wilmer, van den Heuvel, Bencivenga, Bellomo, Levtchenko, Emma: Analysis of CTNS gene transcripts in nephropathic cystinosis. in Pediatric nephrology (Berlin, Germany) 2010 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal CTNS Primary Antibody für ELISA, WB - ABIN560527 : Bellomo, Corallini, Pastore, Palma, Laurenzi, Emma, Taranta: Modulation of CTNS gene expression by intracellular thiols. in Free radical biology & medicine 2010 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal CTNS Primary Antibody für WB - ABIN514757 : Sumayao, McEvoy, Martin-Martin, McMorrow, Newsholme: Cystine dimethylester loading promotes oxidative stress and a reduction in ATP independent of lysosomal cystine accumulation in a human proximal tubular epithelial cell line. in Experimental physiology 2013 (PubMed)

Weitere Antikörper gegen CTNS Interaktionspartner

Human Cystinosis, Nephropathic (CTNS) Interaktionspartner

  1. Cystinosis was primarily diagnosed by a pediatric nephrologist and then referred to the Iran University of Medical Sciences genetics clinic for consultation and molecular analysis, which involved polymerase chain reaction (PCR) amplification to determine the presence or absence of the 57-kb founder deletion in CTNS, followed by direct sequencing of the coding exons of CTNS

  2. Potential dual function of PQ-loop proteins such as cystinosin.

  3. To study the role of the cystinosin-LKG-isoform, we have investigated cystine accumulation and apoptosis that have been described in cystinotic cells. The levels of TNFalpha (zeige TNF Antikörper)- and actinomycin D-inducted apoptosis dropped in cystinotic cells expressing LKG-isoform. This effect was also similar to the main isoform.

  4. This work demonstrated no major abnormality ofER and lysosomal Ca2 (zeige CA2 Antikörper)+signalling associated with cystinosin defi-ciency in human proximal tubular epithelial cells.

  5. The coding exons of the CTNS gene in 5 different Jordanian families and one family from Sudan with nephropathic cystinosis were sequenced. None had the European 57-kb deletion. 7 variants in the coding and promoter sequence of the CTNS gene were found: 294C>T, -180T>C, -118C>T, c.504G>A, p.Thr168Thr, c.829dupA in exon 10, and c.890G>A in exon 11.

  6. Results show that the high turnover of ITILELP mutation (del AA67-73) in cystinosin, because of its immature glycosylation state together with low transport activity, might be responsible for the phenotype observed in some cystinosis patients who carry this mutation.

  7. silencing of AP-2 (zeige GTF3A Antikörper) triggers the clathrin-independent endocytosis, showing the complex adaptability of cystinosin-LKG trafficking

  8. upon comparison of the patients with cystinosis in this particular region with the European and North American patients, it is clear that different CTNS variants result in this disease.

  9. GCK (zeige GCK Antikörper) mutations are associated with Cystinosis.

  10. Lack of cystinosin reduced TFEB (zeige TFEB Antikörper) expression and induced TFEB (zeige TFEB Antikörper) nuclear translocation.

Mouse (Murine) Cystinosis, Nephropathic (CTNS) Interaktionspartner

  1. LAMP2A trafficking is regulated by cystinosin, Rab11, and RILP and that CMA up-regulation is a potential clinically relevant mechanism to increase cell survival in cystinosis.

  2. Data indicate that hematopoietic stem cell (HSC (zeige FUT1 Antikörper)) transplantation in cystinosin knockout (Ctns-/-) thyroid drastically decreased cystine accumulation and normalized the thyroid-stimulating hormone level.

  3. Cells and tissues lacking CTNS expression are characterized by increased autophagosome numbers, but functional macroautophagic flux.

  4. The Ctns(-/-) mouse model generated on C57BL/6 background is not suitable for clarifying the pathogenesis of male infertility in cystinosis.

  5. Deletion of cystinosis gene (Ctns) causes corneal cystine crystals formation, neovascularization and scarring in the cornea of ctns transgenic mice mimicking cystinosis in humans.

  6. the cause of cellular ATP depletion in nephrotic cystinosis may be the futile cycle (zeige LRMP Antikörper), formed between two ATP-dependant gamma-glutamyl cycle enzymes, gamma-glutamyl cysteine synthetase and 5-oxoprolinase (zeige OPLAH Antikörper)

  7. CTNS has a role in proper functioning of the retina and bones, and in mouse behavior

  8. Temporospatial pattern of cystine accumulation in Ctns-/- mice parallels that of patients and validates the mice as a model for the ocular anomalies of cystinosis.

CTNS Antigen-Profil

Protein Überblick

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit CTNS

  • cystinosin, lysosomal cystine transporter (CTNS) Antikörper
  • cystinosin, lysosomal cystine transporter (Ctns) Antikörper
  • cystinosis, nephropathic (Ctns) Antikörper
  • cystinosin, lysosomal cystine transporter (ctns) Antikörper
  • cystinosis, nephropathic (CTNS) Antikörper
  • cystinosin, lysosomal cystine transporter L homeolog (ctns.L) Antikörper
  • AI195360 Antikörper
  • AW049661 Antikörper
  • CTNS Antikörper
  • CTNS-LSB Antikörper
  • PQLC4 Antikörper
  • zgc:110194 Antikörper

Bezeichner auf Proteinebene für CTNS

cystinosin , cystinosis, nephropathic , cystinosin-like , cystinosin, lysosomal cystine transporter

GENE ID SPEZIES
1497 Homo sapiens
417606 Gallus gallus
287478 Rattus norvegicus
83429 Mus musculus
553594 Danio rerio
491220 Canis lupus familiaris
100060554 Equus caballus
748043 Pan troglodytes
706721 Macaca mulatta
780074 Xenopus (Silurana) tropicalis
613527 Bos taurus
431937 Xenopus laevis
100223329 Taeniopygia guttata
100409361 Callithrix jacchus
100443212 Pongo abelii
100592953 Nomascus leucogenys
Ausgewählte Anbieter für anti-CTNS (CTNS) Antikörper
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