Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) Proteine (CFTR)

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Zusätzlich bieten wir Ihnen CFTR Antikörper (359) und CFTR Kits (42) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CFTR 1080 P13569
CFTR 12638 P26361
Ratte CFTR CFTR 24255 P34158
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Showing 6 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag,GST tag   50 μg Anmelden zum Anzeigen 15 bis 18 Tage
$500.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$696.46
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CFTR Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
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Mouse (Murine) ,
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Weitere Proteine zu Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartnern

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Archived data from 15 adult cystic fibrosis (zeige S100A8 Proteine) patients with the CFTR c.1652GA (G551D) mutation.

  2. The pancreatic insufficiency (PI) status was associated with clinical variables and single nucleotide polymorphisms (SNPs) related with inflammatory response considering cystic fibrosis transmembrane conductance regulator (CFTR) mutations.

  3. The data suggest that miR (zeige MLXIP Proteine)-200b may be a suitable target for modulating CFTR levels in vivo.

  4. The mutations found in the promoter region of the CFTR gene in Chinese congenital bilateral absence of the vas (zeige AVP Proteine) deferens patients were different from those in Caucasian populations.

  5. Intragenic CFTR Duplication and 5T/12TG Variant in a Patient with Non-Classic Cystic Fibrosis (zeige S100A8 Proteine).

  6. This study discovers an essential role of CFTR in mediating the retinoic acid-dependent signaling for stem cell differentiation and embryonic development (zeige PLCG1 Proteine).

  7. CFTR stabilizes beta-catenin (zeige CTNNB1 Proteine) and prevents its degradation, defect of which results in the activation of NF-kappaB (zeige NFKB1 Proteine)-mediated inflammatory cascade

  8. There is significant variability in both the frequency and type of mutations present in our study population and in what has been reported in other Latin American countries. It is necessary to perform studies that use complete sequencing technology for the CFTR gene to identify other mutations present in our population

  9. F508 deletion in CFTR was significantly positively associated with chronic pancreatitis (CP) risk in the overall analysis. Indians with F508 deletion had much higher CP prevalence than non-Indians. Interestingly, F508 deletion was also associated with CP and idiopathic CP risk in subgroup analysis stratified by aeitiology, using the fixed effects model. [review, meta-analysis]

  10. This comprehensive CFTR database is now an invaluable tool for diagnostic laboratories gathering information on rare variants, especially in the context of genetic counseling, prenatal and preimplantation genetic diagnosis

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. This study discovers an essential role of CFTR in mediating the retinoic acid-dependent signaling for stem cell differentiation and embryonic development (zeige PLCG1 Proteine).

  2. NDPK-A (zeige NME1 Proteine) exists in a functional cellular complex with AMPK (zeige PRKAA2 Proteine) and CFTR in airway epithelia, and NDPK-A (zeige NME1 Proteine) catalytic function is required for the AMPK (zeige PRKAA2 Proteine)-dependent regulation of CFTR

  3. Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.

  4. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  5. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (zeige ABCB6 Proteine)) transporters.

  6. These data suggest that the Xenopus P2Y1 receptor (zeige P2RY1 Proteine) can increase both cyclic AMP (zeige TMPRSS5 Proteine)/protein kinase A and calcium/protein kinase C levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation

  2. CFTR physically interacts with beta-catenin (zeige CTNNB1 Proteine), defect of which leads to premature degradation of beta-catenin (zeige CTNNB1 Proteine) and suppressed activation of beta-catenin (zeige CTNNB1 Proteine) signaling.

  3. CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.

  4. Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.

  5. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (zeige S100A8 Proteine).

  6. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (zeige GCG Proteine) secretion in alpha cells

  7. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  8. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  9. Insulin (zeige INS Proteine) stimulation of Akt1 (zeige AKT1 Proteine) and Akt2 (zeige AKT2 Proteine) signaling in Cystic fibrosis (zeige S100A8 Proteine) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  10. Biotinylation and streptavidin pull-down assays confirmed that CAL (zeige S100A11 Proteine) dramatically reduces the expression level of total and cell surface Mrp2 (zeige ABCC2 Proteine) in Huh-7 cells. Our findings suggest that CAL (zeige S100A11 Proteine) interacts with Mrp2 (zeige ABCC2 Proteine) and is a negative regulator of Mrp2 (zeige ABCC2 Proteine) expression.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1 (zeige TGFB1 Proteine), via TGF-beta1 (zeige TGFB1 Proteine) receptor I and p38 MAPK (zeige MAPK14 Proteine) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG (zeige SNRPG Proteine)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (zeige S100A8 Proteine) are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (zeige S100A8 Proteine) pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas (zeige AVP Proteine) deferens and/or epididymis atresia at birth

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (zeige DNASE1 Proteine) hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results demonstrate functional coupling between Cftr and Slc26a6 (zeige SLC26A6 Proteine)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

Zebrafish Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Molecular dynamics of the cryo-EM CFTR structure

  2. Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.

  3. Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis (zeige S100A8 Proteine)-causing missense mutational sites are identical.

  4. Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis (zeige S100A8 Proteine) of the human pancreas.

CFTR Protein Überblick

Protein Überblick

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Genbezeichner und Symbole assoziert mit CFTR

  • cystic fibrosis transmembrane conductance regulator (CFTR)
  • cystic fibrosis transmembrane conductance regulator (cftr-A)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR)
  • cystic fibrosis transmembrane conductance regulator (Cftr)
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr)
  • abc35 Protein
  • abcc7 Protein
  • AW495489 Protein
  • CF Protein
  • CFTR Protein
  • cftr/mrp Protein
  • dJ760C5.1 Protein
  • mrp7 Protein
  • RGD1561193 Protein
  • si:dkey-270i2.2 Protein
  • tnr-cftr Protein
  • xcftr Protein

Bezeichner auf Proteinebene für CFTR

cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase , abcc7

GENE ID SPEZIES
1080 Homo sapiens
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
100049619 Gallus gallus
492302 Canis lupus familiaris
100071259 Equus caballus
403154 Sus scrofa
281067 Bos taurus
443347 Ovis aries
100009471 Oryctolagus cuniculus
463674 Pan troglodytes
100137035 Pongo abelii
100719898 Cavia porcellus
100381094 Xenopus laevis
100126675 Papio anubis
559080 Danio rerio
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