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The protein encoded by CDK5R2 is a neuron-specific activator of CDK5 kinase. Zusätzlich bieten wir Ihnen Cyclin-Dependent Kinase 5, Regulatory Subunit 2 (p39) Antikörper (31) und und viele weitere Produktgruppen zu diesem Protein an.
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p39 is essential for recruiting scaffolding protein muskelin to stress fibers.
Structural basis for the different stability and activity between the Cdk5 complexes with p35 and p39 activators.
Hepatocellular carcinoma patients with lower p39 expression had poorer overall survival rate than that with high expression.
both proteasomal degradation and calpain cleavage of p35 and p39 are stimulated by membrane association, which is in turn mediated via myristoylation of their p10 regions.
Our data suggest that neurotoxic insults lead to calpain-mediated conversion of p39 to p29, which might contribute to deregulation of Cdk5
role of the CDK5 molecular complex in the genetic etiology of early-onset Alzheimer disease; a yet unknown functional variant in CDK5 or in a nearby gene might lead to increased susceptibility for early-onset Alzheimer disease
that the knockout of p39 in mice did not affect orofacial and peripheral nociception
In this study, we discovered that selective upregulation of p39 is the underlying mechanism that accommodates the increased functional requirement of Cdk5 activation during neuronal differentiation. In addition, we demonstrated that p39 selectively directs Cdk5 to phosphorylate protein substrates essential for axonal development, dendritic spine formation, and synaptogenesis. Moreover, our studies suggest opposing roles o
These data suggest p35 and p39 have specific and overlapping roles in oligodendrocyte development, some of which may be independent of Cdk5 activation.
it was found that Tyr-15 phosphorylation occurred only on monomeric Cdk5, and the coexpression of activators, p35/p25, p39, or Cyclin I, inhibited the phosphorylation.
Data indicate that p39 is selectively up-regulated in oligodendroglia (OL) during differentiation along with elevated Cdk5 activity.
A set of REST target genes, including Cdk5r2, is important for beta cell survival.
The alternating p39 parasagittal band pattern may reflect a role for p39 or Cdk5/p39 in the functional compartmentation of the cerebellum.
Data show that both p35 and p39 are expressed in insulin-secreting beta cells, where they exhibit individual subcellular distributions and associate with membranous organelles of different densities.
These findings demonstrate that Cdk5, p35, and p39 are endogenously expressed in NG108-15 cells, exhibit distinct subcellular localizations, and that both Cdk5/p35 and Cdk5/p39 are central in formation of functional synapses.
The differential nuclear accumulation of p39 and p35 suggests their segregated functions, p35-Cdk5 in the cytoplasm and p39-Cdk5 in the nucleus.
The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
, cyclin-dependent kinase 5 activator 2
, cyclin-dependent kinase 5, regulatory subunit 2-like
, CDK5 activator 2
, cyclin-dependent kinase 5 activator isoform p39i
, cyclin-dependent kinase 5 regulatory subunit 2
, neuronal CDK5 activator isoform