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CCNT1 encodes a member of the highly conserved cyclin C subfamily.
Showing 10 out of 72 products:
Cow (Bovine) Polyclonal Cyclin T1 Primary Antibody für WB - ABIN2792158
Sun, Zheng, Zhao, Lee, Goldstein: Increased in vivo activation of microglia and astrocytes in the brains of mice transgenic for an infectious R5 human immunodeficiency virus type 1 provirus and for CD4-specific expression of human cyclin T1 in response to stimulation by lipopolysaccharide in Journal of virology 2008
Human Polyclonal Cyclin T1 Primary Antibody für EIA, FACS - ABIN951765
Moiola, De Luca, Gardner, Vazquez, De Siervi: Cyclin T1 overexpression induces malignant transformation and tumor growth. in Cell cycle (Georgetown, Tex.) 2010
Show all 5 Pubmed References
We conclude that a subset of non-paused, pre-cellular genes are among the most susceptible to reduced P-TEFb (zeige CDK9 Antikörper), SEC and Mediator levels in Drosophila embryos.
following P-TEFb (zeige CDK9 Antikörper) inhibition, most polymerases were restricted to within 150 bp of the transcription initiation site of the active Drosophila melanogaster Hsp70 gene, and live-cell imaging demonstrated that these polymerases were stably associated
ASF/SF2 (zeige SRSF1 Antikörper) is identified as a splicing regulator (zeige PTBP2 Antikörper) of cyclin T1, which contributes to the control of the subsequent transcription events.
The TAR (zeige RBM8A Antikörper) central loop contacts the CycT1 Tat (zeige TAT Antikörper)-TAR (zeige RBM8A Antikörper) recognition motif (TRM) and the second Tat (zeige TAT Antikörper) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 (zeige AFF4 Antikörper) helix 2 is stabilized in the TAR (zeige RBM8A Antikörper) complex despite not touching the RNA, explaining how it enhances TAR (zeige RBM8A Antikörper) binding to the SEC 50-fold.
Quantitative measurement of the molecular interactions among Tat (zeige TAT Antikörper), CycT1 and CDK9 (zeige CDK9 Antikörper) has showed that any third molecule enhances the binding between the other two molecules. These findings suggest that each component of the Tat:P-TEFb (zeige TEF Antikörper) complex stabilizes the overall complex, thereby supporting the efficient transcriptional elongation during viral RNA synthesis.
the introduction of HIV-1 Tat (zeige TAT Antikörper) and Mg12+ ion resulted in the active site architectural characteristics of phosphorylated CDK9 (zeige CDK9 Antikörper)/cyclin T1 complex
AFF4 (zeige AFF4 Antikörper) is positioned to make unexpected direct contacts with HIV Tat (zeige TAT Antikörper), and Tat (zeige TAT Antikörper) enhances P-TEFb/CCNT1 affinity for AFF4 (zeige AFF4 Antikörper).
Plk1 (zeige PLK1 Antikörper) negatively regulates the RNA polymerase II (zeige 0 Antikörper)-dependent transcription through inhibiting the activity of cyclin T1/Cdk9 (zeige CDK9 Antikörper) complex.
The sequence domain of human cytomegalovirus pUL97 responsible for the interaction with cyclin T1 was between amino acids 231-280.
the release of P-TEFb from the 7SK snRNP (zeige LSM2 Antikörper) led to increased synthesis of HEXIM1 (zeige HEXIM1 Antikörper) but not HEXIM2 (zeige HEXIM2 Antikörper)
All of the hCD4/R5/cT1 (zeige CTF1 Antikörper) mice developed disseminated infection of tissues that included the spleen, small intestine, lymph nodes and lungs after intravenous injection with an HIV-1 infectious molecular clone
positive transcription elongation factor b (P-TEFb (zeige CDK9 Antikörper), made of CDK9 (zeige CDK9 Antikörper) and CycT1) is released from its inhibitory complex by histone deacetylase (zeige HDAC1 Antikörper) inhibitors, which also activate HIV transcription
Data show that the minimal 90-amino acid AF9 (zeige MLLT3 Antikörper) fragment in MLL (zeige MLL Antikörper)-AF9 (zeige MLLT3 Antikörper) retains an ability to form higher order complexes with AF4*P-TEFb and with DOT1 (zeige DOT1L Antikörper).
Data show that the CDK9 (zeige CDK9 Antikörper) and cyclin T1 subunits of P-TEFb are present in mouse oocytes and preimplantation embryos, and that CDK9 (zeige CDK9 Antikörper) is essential for embryonic genome activation in the mouse.
Cyclin T1 oncogenic function and suggest a role for this protein in controlling cell cycle probably via Rb/E2F1 (zeige E2F1 Antikörper) pathway.
CDK9 (zeige CDK9 Antikörper) has the intrinsic property to shuttle between nucleus and cytoplasm, and enhanced expression of cyclin T1 promotes its nuclear localization.
P-TEFb is a key mediator of Myc (zeige MYC Antikörper) activated transcription by stimulating elongation
Tat (zeige TAT Antikörper) and trans-activation-responsive (TAR (zeige RBM8A Antikörper)) RNA-independent induction of HIV-1 long terminal repeat by this protein requires Sp1 (zeige SP1 Antikörper).
cyclin T1 binds with granulin (zeige GRN Antikörper) to inhibit transcription
location of the cyclin T1 gene regulatory elements is male germ cell-specific
These data link the P-TEFb equilibrium to the intracellular transcriptional demand and proliferative/differentiated states of cells.
knockdown of CycT1 from P-TEFb abolishes both of the different chromatin loops regulating CD4 (zeige CD4 Antikörper) expression
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
, cyclin T
, cyclin T1
, cyclin T2
, dCyclin T
, CDK9-associated C-type protein
, cyclin C-related protein
, human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
, cyclin T1 protein