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The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors.
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EGF-induced, calpain-mediated proteolysis contributes to the rapid destruction of cyclin G2 and that the PEST domain is critical for EGF/calpain actions
Taken together, our novel findings demonstrate that cyclin G2 has potent tumor-suppressive effects in Epithelial ovarian cancer (EOC) by inhibiting EMT (zeige ITK ELISA Kits) through attenuating Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) signaling.
CCNG2 knockdown eradicated the effects of miR (zeige MLXIP ELISA Kits)-340 silencing.
Neisseria meningitidis caused changes in the abundance of several cell cycle regulatory mRNAs, including the cell cycle inhibitors p21(WAF1/CIP1 (zeige CDKN1A ELISA Kits)) and cyclin G2 in human brain microvascular endothelial cells.
miR (zeige MLXIP ELISA Kits)-93-CCNG2 axis may be involved in Laryngeal squamous cell carcinoma proliferation and progression.
Data shows the human CCNG2 and CDK4 (zeige CDK4 ELISA Kits) expression of visceral adipose tissue are inversely associated with glucose and insulin (zeige INS ELISA Kits) resistance.
Data (from studies using BeWo cells, a choriocarcinoma cell line, as model of placentation) suggest that miR (zeige MLXIP ELISA Kits)-378a-5p (microRNA 378a) inhibits cell differentiation in syncytiotrophoblasts, in part, by down-regulating CCNG2 (cyclin G2) expression.
miR (zeige MLXIP ELISA Kits)-1246 expression was associated with chemoresistance and CSC-like properties via CCNG2, and could predict worse prognosis in pancreatic cancer patients
Cyclin G2-involved invasion in vitro and in vivo.
Low CCNG2 expression is associated with thyroid cancer.
CycG2 controls the dephosphorylation of the DNA repair-related factors gammaH2AX (zeige H2AFX ELISA Kits) and CHK2 (zeige CHEK2 ELISA Kits)-pT68 at DNA repair foci.
our results demonstrate a novel role for cyclin G2 in the regulation of adipogenesis.
These results show that FoxO (zeige FOXO3 ELISA Kits) genes regulate cyclin G2 expression, illustrating a new role for phosphoinositide 3-kinase and FoxO (zeige FOXO3 ELISA Kits) transcription factors in the control of cell cycle entry.
cyclin G1 (zeige CCNG1 ELISA Kits) and cyclin G2 genes are differentially regulated in the periimplantation uterus in a spatiotemporal manner; results suggest cyclin G1 (zeige CCNG1 ELISA Kits) and cyclin G2 genes act as downstream targets of homeobox (zeige PRRX1 ELISA Kits) A-10 and negatively impact uterine cell proliferation
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle.