Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 Proteine (C1GALT1)

The protein encoded by C1GALT1 generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Zusätzlich bieten wir Ihnen Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 Antikörper (36) und Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
C1GALT1 56913 Q9NS00
C1GALT1 94192 Q9JJ06
C1GALT1 65044 Q9JJ05
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$492.31
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,982.83
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,990.17
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,004.83
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C1GALT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus)

Weitere Proteine zu Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Interaktionspartnern

Human Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Interaktionspartner

  1. findings indicate that T-synthase deficiency in colorectal cancer cells not only is responsible for aberrant O-glycosylation, but also triggers the molecular process of EMT pathway, which may translate to increased invasiveness and metastasis in cancers

  2. In addition, we found that Tn-expressing colorectal cancers (CRC) cell lines had either loss-of-function mutations in Cosmc or reversible Tn antigen expression, which was not caused by the deficiency of T-synthase activity

  3. There was no relationship between rs1047763 and rs1008898 C1GALT1 polymorphisms and susceptibility to IgA nephropathy. (Meta-analysis)

  4. C1GALT1 modifies O-glycan expression and enhances malignant behaviors in ovarian cancer cells, suggesting that C1GALT1 plays a role in the pathogenesis of ovarian cancer.

  5. These findings demonstrate that common variation at C1GALT1 influences Gd-IgA1 level in the population, which independently associates with risk of progressive IgA nephropathy, and that the pathogenic importance of changes in IgA1 O-glycosylation may vary between white and Chinese patients with IgA nephropathy

  6. Polymorphisms near C1galt1 (rs10486157) and its molecular chaperone, Cosmc (rs4825729), were associated with altered composition of the colonic mucosal microbiota in Crohn's disease patients.

  7. Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.

  8. The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1. TGFbeta1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGFbeta1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc.

  9. There was no statistically significant difference between the two groups (P > 0.05). The rs1047763 SNP of the C1GALT1 gene probably has no correlation with genetic susceptibility to IgAN in Xinjiang Uyghur people.

  10. Polymorphisms in the C1GALT1 gene were associated with genetic susceptibility to Uyghur Immunoglobulin A (IgA) nephropathy.

  11. Overexpression of C1GALT1 enhanced breast cancer cell growth, migration, and invasion in vitro as well as tumor growth in vivo.

  12. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity.

  13. Cosmc and T-synthase are transcriptionally regulated at a basal level by the specificity protein/Kruppel-like transcription factor family of members.

  14. Using qRT-PCR, sialyl-Tn expression was found to be associated with an increase in alpha2,6-sialyltransferase gene (ST6GALNAC1) and a decrease in core 1 synthase gene (C1GALT1) in LS174T cells.

  15. C1GALT1 overexpression modifies O-glycans on FGFR2 and enhances its phosphorylation to promote the invasive behavior and cancer stem-like property in colon cancer cells.

  16. Variations in the C1GALT1 gene were found to be associated with Henoch-Schonlein purpura risk.

  17. Data indicate that cytotoxin associated gene A protein (CagA) promoted the underglycosylation of IgA1, which at least partly attributed to the downregulation of beta1,3-galactosyltransferase (C1GALT1) and its chaperone Cosmc.

  18. Il-6 and Il-4 reduced galactosylation of the O-glycan substrate directly via decreased expression of the galactosyltransferase C1GalT1 and, indirectly, via increased expression of the sialyltransferase ST6GalNAc-II

  19. Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells.

  20. High C1GALT1 enhances proliferation of hepatocellular carcinoma cells via modulating MET glycosylation and dimerization.

Mouse (Murine) Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Interaktionspartner

  1. pancreas-specific conditional KO of C1galt1 expression of truncated O-glycans, which in turn accelerates Pancreatic ductal adenocarcinomas (PDACs) progression and metastasis.

  2. hepatic asialoglycoprotein receptor promotes preferential adherence to and phagocytosis of desialylated and/or HC C1galt1(-/-) platelets by the Kupffer cell through its C-type lectin receptor CLEC4F. These findings provide insights into an essential role for core 1 O-glycosylation of platelets in their clearance in the liver.

  3. Deletion of C1galt1 in mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course due to loss of mucin core-1 derived O-glycans.

  4. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity.

  5. O-glycan is required for terminal megakaryocyte differentiation and platelet production and the decrease in GPIbalpha in cells lacking O-glycan might be caused by increased proteolysis.

  6. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; C1galt1 and MGAT1 are required for embryo development and implantation.

  7. disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology

  8. It was found that targeted disruption of this gene causes embryonic lethality and defective angiogenesis in mice.

  9. Transgenic mice were generated lacking T-synthase (C1galt1).

Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Protein Überblick

Protein Überblick

The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.

Genbezeichner und Symbole assoziert mit C1GALT1

  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1)
  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b (c1galt1b)
  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1galt1)
  • glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 L homeolog (LOC100496837.L)
  • 2210410E06Rik Protein
  • AV284120 Protein
  • C1GALT Protein
  • C1GALT1 Protein
  • fa98f05 Protein
  • T-synthase Protein
  • wu:fa98f05 Protein
  • zgc:66485 Protein

Bezeichner auf Proteinebene für C1GALT1

C1GalT1-B , core 1 O-glycan T-synthase B , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B , core 1 beta1,3-galactosyltransferase 1-B , core 1 beta3-Gal-T-B , core 1 beta3-Gal-T1-B , core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-like , B3Gal-T8 , core 1 O-glycan T-synthase , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 , core 1 beta3-Gal-T1 , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 , T-syn , core 1 beta1,3-galactosyltransferase 1 , core 1 beta3-Gal-T , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase (C1galt1) , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 13-galactosyltransferase (C1galt1) , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galac

GENE ID SPEZIES
482314 Canis lupus familiaris
337131 Danio rerio
472288 Pan troglodytes
100406487 Callithrix jacchus
100483848 Ailuropoda melanoleuca
56913 Homo sapiens
94192 Mus musculus
65044 Rattus norvegicus
539417 Bos taurus
420575 Gallus gallus
444326 Xenopus laevis
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