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CR2 encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes.
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This study shown the C3d (zeige C3 Proteine)+ microglial clusters were found in chronic but not acute multiple sclerosis.
This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.
Binding of PF4 (zeige PF4 Proteine)/heparin complexes to B (zeige TDO2 Proteine) cells is mediated through the interaction between complement and complement receptor 2.
high pERK (zeige EIF2AK3 Proteine) expression and accelerated apoptosis revert within 4 weeks after beginning therapy, whereas clonal B cells unresponsive to TLR9 (zeige TLR9 Proteine) stimulation persist for at least 24 weeks, although they may partially rescue normal CD21 expression.
Cerebrospinal fluid (CSF (zeige CSF2 Proteine)) soluble complement receptor 2 (sCR2 (zeige RBMS1 Proteine)) levels correlated significantly both with CSF (zeige CSF2 Proteine) complements C3 and C1q as well as to a disease severity measure.
CR2 contributes to human Osteonecrosis of the femoral head susceptibility in Korean systemic lupus erythematosus patients.
In this study, we have shown that the CR2 +24T>C polymorphism is not a risk marker for nasopharyngeal carcinoma development in the North region of Portugal.
In mature B cells, CD21 transcription proceeds from a focused transcriptional start site regulated by a non-consensus TATA box, an initiator element and a downstream promoter element.
Reduced expression of CD21 on CLL B-cells appears functionally relevant and was associated with poor clinical outcomes.
These data suggest that rs1876453 in CR2 has long-range effects on gene regulation that decrease susceptibility to systemic lupus erythematosus.
Cattle express two major variants of the Cr2 gene representing homologues of murine CR1 and CR2, each of which is expressed in both a long and a short form.
These results demonstrate that local expression of Cr2 in the central nervous system is part of the axotomy reaction and is suggested to modulate subsequent complement mediated effects.
This study demonistrated that receptors for complement C3 (zeige C3 Proteine) fragments (CR2/CR1) may represent a promising future approach for therapeutic immunomodulation after traumatic brain injury.
Data suggest that the Cr2KO mouse thus provides a new model system for the analysis of Cr1 and Cr2 functions in the immune response of the mouse.
Murine B cells predominantly express the Cr2 product from the Cr2 gene, whereas follicular dendritic cells (FDCs) almost exclusively express the Cr1 isoform generated from the Cr2 gene.
immune system uses three different CR1 (zeige TDGF1 Proteine)/2-mediated effector functions to generate optimal antibody responses
Absence of CD21/35 protects mice from chronic wasting disease.
We conclude that Cr2 regulates hippocampal neurogenesis
There is a significant reduction in the numbers of both neutrophils and macrophages in cardiac isografts isolated from mice treated with either complement receptor 2-Crry (zeige CR1L Proteine) or CR2-factor H (zeige CFH Proteine).
Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells.
functionally significant phenotype for the NZM2410 Cr2 allele and strongly support its role as a lupus susceptibility gene
This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, complement C3d receptor
, complement receptor type 2
, epstein-Barr virus receptor
, complement component receptor 2
, complement receptor 1 long isoform
, complement receptor 2
, complement receptor type 1
, expressed in B lymphocytes