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CRMP1 encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. Zusätzlich bieten wir Ihnen CRMP1 Antikörper (105) und CRMP1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human CRMP1 Protein expressed in HEK-293 Cells - ABIN2712565
Braunschweig, Krakowiak, Duncanson, Boyce, Hansen, Ashwood, Hertz-Picciotto, Pessah, Van de Water: Autism-specific maternal autoantibodies recognize critical proteins in developing brain. in Translational psychiatry 2013
Study shows that CRMP1 acts an EMT and metastasis suppressor in prostate cancer cells via its regulation of actin polymerization.
Identify CRMP-1 as a novel regulator of actin filament elongation and reveal a surprisingly important role for CRMP-1, EVL, and actin polymerization in maintaining the structural integrity of epithelial sheets.
The present study reports that miR (zeige MLXIP Proteine)-187 was significantly overexpressed in gastric cancer tissues compared to that in non-tumor tissues and was associated with malignant clinical factors such as depth of invasion (P = 0.005), tumor size (P = 0.024), lymph node metastasis . It was found that collapsin response mediator protein 1 (CRMP1), a tumor suppressor, was a direct downstream target of miR (zeige MLXIP Proteine)-187.
miR200a-3p promotes the proliferation of human esophageal cancer cells by post-transcriptionally regulating CRMP1.
CRMP1 interacted with Spy1 (zeige SPDYA Proteine) which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A (zeige SEMA3A Proteine) and regeneration after sciatic nerve crush.
These results demonstrate an important role for CRMP-1 in Listeria actin comet tail formation and open the possibility that CRMP-1 controls cell motility by modulating Arp2 (zeige ACTR2 Proteine)/3 activation.
Human CRMP-1 comprises a tetrameric assembly.
Results show that expression of CRMP1 is downregulated in medulloblastoma (MB) tumors. its overexpression inhibits proliferation, migration and invasion of cells suggesting that CRMP1 is implicated in MB pathogenesis.
Aberrant upregulation of CRMP-1 expression may link to the mechanism of developing early-onset preeclampsia.
CRMP1 targets aggregation-prone, N-terminal HTT (zeige HTT Proteine) fragments and suppresses their spontaneous self-assembly.
Results indicate that CRMP1 and CRMP4 (zeige DPYSL3 Proteine) regulate proper orientation of the basal dendrites of layer V neurons in the cerebral cortex during development.
this paper shows that Nav1.7 (zeige SCN9A Proteine), by coupling with CRMP1, mediates the axonal retrograde signaling of Sema3A (zeige SEMA3A Proteine) in axonal guidance
We generated CRMP2 (zeige DPYSL2 Proteine) gene-deficient (crmp2 (zeige DPYSL2 Proteine)(-/-) ) mice. The crmp2 (zeige DPYSL2 Proteine)(-/-) mice showed irregular development of dendritic spines in cortical neurons. The level of CRMP1 was increased in crmp2 (zeige DPYSL2 Proteine)(-/-) , but the level of CRMP2 (zeige DPYSL2 Proteine) was not altered in crmp1(-/-).The phenotypic defects had no genetic interaction between crmp1 and crmp2 (zeige DPYSL2 Proteine).
LCRMP (zeige DPYSL3 Proteine)-1 and CRMP-1 have opposing functions in regulating cancer cell invasion and metastasis
Data demonstrate that CRMP1 tyrosine 504 is a primary target of the Src (zeige SRC Proteine) family of tyrosine kinases (SFKs), specifically Fyn (zeige FYN Proteine).
Data link the reduction in PMCA2 (zeige ATP2B2 Proteine) expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA (zeige GRIA3 Proteine)/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE.
The structural bases for Crmp1 function in plexin-dependent sempahorin3A signaling were studied.
In the olfactory bulb, CRMP1, CRMP2 (zeige DPYSL2 Proteine) and CRMP5 (zeige DPYSL5 Proteine) are abundant in neuronal progenitors of the subependymal layer and in differentiating interneurons.
Mice lacking Crmp1 showed a decrease in the number of granule cells migrating out of explants of developing cerebellum.
Collapsin response mediator protein 1 (CRMP1)regulates neuronal migration by mediating Reelin (zeige RELN Proteine) signaling.
Crmp1 is expressed in numerous sites in the developing nervous system
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
collapsin response mediator protein 1
, cysteine repeat modular protein 1, putative
, dihydropyrimidinase related protein-1
, dihydropyrimidinase-like 1
, dihydropyrimidinase-related protein 1
, unc-33-like phosphoprotein 3
, collapsin response mediator protein-1B