Collagen, Type XVII, alpha 1 Proteine (COL17A1)

COL17A1 encodes the alpha chain of type XVII collagen. Zusätzlich bieten wir Ihnen COL17A1 Antikörper (43) und COL17A1 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte COL17A1 COL17A1 294027  
COL17A1 1308 Q9UMD9
COL17A1 12821 Q07563
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days

COL17A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Weitere Proteine zu Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartnern

Human Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. C-terminal processing induces dynamic structural changes and neoepitopes for linear IgA dermatosis autoantibodies on COL17

  2. The corneal dystrophy mapped to chromosome 10q23-q24 is associated with the c.3156C>T variant in COL17A1.

  3. Data suggest that type XVII collagen (COL17) internalization/macropinocytosis by keratinocytes induced by IgG autoantibodies from patients with bullous pemphigoid (BP) is mediated by PKC (protein kinase C) calcium signaling pathway; BP IgG induced overabundant phosphorylation of COL17.

  4. we have produced five new versatile monoclonal antibodies against the Col 17 endodomain that are superior to ectodomain antibodies in diagnosing and differentiating between JEB-gen intermed and JEB-loc (zeige ILK Proteine)/carriers

  5. Results show that aberrant epigenetic control is a key driver of COL17A1 gene misexpression and tumor cell invasion in a variety of epithelial neoplasm. These findings have significant clinical implications, suggesting that the COL17A1 promoter methylation status can be used to predict patient outcome.

  6. Case Report: IgA autoantibodies targeting the NC16A domain rather than the shed ectodomains of COL17 resulted in linear IgA bullous dermatosis (zeige LAD1 Proteine) in a pregnant woman.

  7. ELISA for IgE anti-NC16a is a helpful parameter in the modification of current treatment and the assessment of risk of relapse in bullous pemphigoid (zeige DST Proteine).

  8. R1303Q in COL17 hampers C-terminal cleavage of COL17. Increase in remnants of non-cleaved COL17 ectodomain in extracellular matrix (ECM (zeige MMRN1 Proteine)) induces aberrant laminin 332 deposition in ECM (zeige MMRN1 Proteine), which may be associated with disorganized basement membrane formation.

  9. The COL17A1 c.3156C-->T variant is the likely causative mutation in our recurrent corneal erosion families, and its presence in 4 independent families suggests that it is prevalent in epithelial recurrent erosion dystrophy.

  10. Elevated serum levels of BP180 antibodies in the first trimester of pregnancy precede gestational pemphigoid and remain elevated for a long time after remission of the disease.

Mouse (Murine) Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. The aging process can be recapitulated by Col17a1 deficiency and prevented by the forced maintenance of COL17A1 in hair follicle stem cell (HFSCs), demonstrating that COL17A1 in HFSCs orchestrates the stem cell-centric aging program of the epithelial mini-organ.

  2. The deletion of the bullous pemphigoid (zeige DST Proteine) epitope region of collagen XVII induces blistering, autoimmunization, and itching in a mouse disease model.

  3. Through an unbiased genetic approach involving a combination of QTL mapping and positional cloning, we demonstrate that Col17a1 is a strong genetic modifier of the non-Herlitz JEB that develops in Lamc2 (zeige LAMC2 Proteine)(jeb) mice

  4. These results provide mechanistic evidence that ColXVII coordinates keratinocyte adhesion and directed motility by interfering integrin dependent PI3K activation and by stabilizing lamellipodia

  5. Neutrophil elastase (zeige ELANE Proteine) cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid (zeige DST Proteine)

  6. Analysis of Col17a1-null mice revealed that COL17A1 is critical for the self-renewal of hair follicle stem cells through maintaining their quiescence and immaturity.

  7. bullous pemphigoid antigen 2 has a role in eliciting specific IgG and the immune responses arising in epidermolysis bullosa

  8. ADAM9 (zeige ADAM9 Proteine) and ADAM10 (zeige ADAM10 Proteine) can both contribute to collagen XVII shedding in skin.

Cow (Bovine) Collagen, Type XVII, alpha 1 (COL17A1) Interaktionspartner

  1. results show that the cleavage of BP180 occurring within the NC16A domain is mediated by a membrane-associated metalloprotease and suggest involvement of the cleavage in hemidesmosomal disassembly(bullous pemphigoid antigen 180/type XVII collagen)

COL17A1 Protein Überblick

Protein Überblick

This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

Genbezeichner und Symbole assoziert mit COL17A1

  • collagen type XVII alpha 1 chain (Col17a1)
  • collagen, type XVII, alpha 1b (col17a1b)
  • collagen type XVII alpha 1 chain (COL17A1)
  • collagen, type XVII, alpha 1 (Col17a1)
  • BA16H23.2 Protein
  • BP180 Protein
  • BPA-2 Protein
  • Bpag Protein
  • Bpag2 Protein
  • COL17A1 Protein
  • fk89a06 Protein
  • LAD-1 Protein
  • si:ch211-223p8.6 Protein
  • wu:fk89a06 Protein

Bezeichner auf Proteinebene für COL17A1

collagen alpha-1(XVII) chain , procollagen, type XVII, alpha 1 , col17a1a , collagen, type XVII, alpha 1 , collagen alpha-1(XVII) chain-like , 180 kDa bullous pemphigoid antigen 2 , alpha 1 type XVII collagen , bA16H23.2 (collagen, type XVII, alpha 1 (BP180)) , bullous pemphigoid antigen 2 (180kD) , collagen XVII, alpha-1 polypeptide , bullous pemphigoid antigen 2 , bullous pemphigoid antigen 180 , novel collagen protein , Collagen alpha-1(XVII) chain , bullous pemphigoid autoantigen 2 , Bullous pemphigoid antigen 2 , collagen type XVII

294027 Rattus norvegicus
568794 Danio rerio
100452122 Pongo abelii
100069671 Equus caballus
100604365 Nomascus leucogenys
1308 Homo sapiens
12821 Mus musculus
513804 Bos taurus
396503 Gallus gallus
403739 Canis lupus familiaris
101843802 Mesocricetus auratus
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