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COL10A1 encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Zusätzlich bieten wir Ihnen Collagen, Type X, alpha 1 Antikörper (25) und Collagen, Type X, alpha 1 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human COL10A1 ELISA Kit für Sandwich ELISA - ABIN415303
Venkatesan, Ekici, Madry, Schmitt, Kohn, Cucchiarini: SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells. in Stem cell research & therapy 2012
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Results indicate that Cox-2 (zeige COX2 ELISA Kits) promotes Col10a1 expression and chondrocyte hypertrophy in vitro.
In a model of instability-induced osteoarthritis, Col (zeige HDAC1 ELISA Kits) X was overexpressed in articular chondrocytes and osteophyte-forming cells in LOX-1 (zeige OLR1 ELISA Kits)(+)/(+) mice and was significantly downregulated in articular chondrocytes and osteophyte-forming cells in LOX-1 (zeige OLR1 ELISA Kits)(-)/(-) mice.
Col10 expression was seen in the hypertrophic zone at and below the tidemark of the mandibular condyle cartilage.
These data support a Cox-2 (zeige COX2 ELISA Kits)-containing, Runx2 (zeige RUNX2 ELISA Kits)-centered Col10a1 regulatory mechanism, during chondrocyte hypertrophic differentiation.
Data indicate Indian hedgehog (Ihh (zeige IHH ELISA Kits)) induces collagen type X COL10A1 expression and promotes its transcription through Runx2 (zeige RUNX2 ELISA Kits)/Smad1 (zeige SMAD1 ELISA Kits) interactions on a specific promoter region.
these results show that increased Col10a1 expression in Phex (zeige PHEX ELISA Kits)-deficient osteoblasts is not a major cause of the XLHR phenotype, which was an important issue to address based on the previous findings
Downregulation of carbonic anhydrase IX (zeige CA9 ELISA Kits) promotes Col10a1 expression in chondrocytes.
Runx2 directly interacts with murine Col10a1 cis-enhancer.
SOX9 (zeige SOX9 ELISA Kits) directly represses Col10a1 expression in immature/proliferating chondrocytes of the growth plate
Studies indicate that Col10a1 is highly expressed in hypertrophic chondrocytes and commonly used as a gene marker for this cell population.
All affected individuals are heterozygous for the missense mutation collagen type X alpha 1 chain (COL10A1) rs111033552.
increased expression of stromal colXalpha1 and low TILs correlate with poor pathologic response in ER+/HER2 (zeige ERBB2 ELISA Kits)+ breast tumors. Further studies are needed to confirm their predictive value and impact on long-term outcomes, and to determine whether this collagen exerts a protective effect on the cancer cells or simply reflects other factors within the tumor microenvironment
a novel sequence variation involving an unusual mutational site of the COL10A1 gene can cause mild metaphyseal chondrodysplasia (zeige COL11A1 ELISA Kits)
COL10A1 mutation 2005delC in a Chinese pedigree with Schmid type metaphyseal chondrodysplasia (zeige COL11A1 ELISA Kits) is close to the C-terminus of the protein sequence and may result in genetic heterogeneity of the Chinese population
The results show that COL10A1 is a tumor biomarker upregulated in a wide variety of tumors including those of the breast, colon, bladder, stomach, esophagus, lung, testis, ovary and pancreas.
Yiqi Huayu Bushen Recipe increased the expression of aggrecan (zeige ACAN ELISA Kits), decreased the expression of type X collagen, and promoted cell proliferation in cells from degenerated human intervertebral discs.
Genetic variation near FRK (zeige FRK ELISA Kits)/COL10A1 and VEGFA (zeige VEGFA ELISA Kits) are associated with advanced age-related macular degeneration.
MCDS is a rare genetic skeletal disorder caused by a collagen type X defect. Though much is known about the molecular pathology of the causative COL10A1 mutations, causal therapy of the disease is not yet available
a frameshift mutation leading to elongation of the deduced alpha1(X) chain associated with Metaphyseal Chondrodysplasia (zeige COL11A1 ELISA Kits) type Schmid
The effect of parathyroid hormone on expression of COL10 and COL2 in mesenchymal stem cells from osteoarthritic patients and analyzed the potential mechanisms related to its effect, was investigated.
The 4.6 kb promoter is able to drive specific expression of Col10a1 in hypertrophic cartilage.
TSG is an important modulator of BMP-regulated induced collagen II and X expression and cartilage development and chondrocyte differentiation
This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD).
collagen alpha-1(X) chain
, procollagen, type X, alpha 1
, Schmid metaphyseal chondrodysplasia
, collagen X, alpha-1 polypeptide
, collagen, type X, alpha 1 (Schmid metaphyseal chondrodysplasia)
, collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)
, type X collagen alpha 1
, LOW QUALITY PROTEIN: collagen alpha-1(X) chain
, collagen, type X, alpha 1