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COL5A2 encodes an alpha chain for one of the low abundance fibrillar collagens. Zusätzlich bieten wir Ihnen COL5A2 Antikörper (30) und COL5A2 Kits (21) und viele weitere Produktgruppen zu diesem Protein an.
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Bladder cancer patients in COL5A2 low expression group were associated with better invasiveness (P < .0001), tumor grade (P=.001), T staging (P < .0001), N staging (P = .002), and a trend of better M staging (P = .053) than those in COL5A2 high expression group. These results indicated that COL5A2 might promote the progression of Bladder Cancer cells.
COL5A2(+/-) humans, although unlikely to present with frank classic Ehlers-Danlos syndrome, are likely to have fragile connective tissues with increased susceptibility to trauma and certain chronic pathologic conditions.
data confirm that COL5A1 and COL5A2 are the major, if not the only, genes involved in classic Ehlers-danlos syndrome
Col5a2 shows predictive potential in myocardial infarction , and in principle may represent a novel candidate marker for the identification and treatment of ischemic cardiovascular disease
study shows that over 90% of patients, which strictly satisfy all major Villefranche criteria for classic Ehlers-Danlos Syndrome (EDS)harbor a type V collagen defect which indicates that this is the major--if not only--cause of classic EDS
This study suggests a fetal association of COL5A2 and a combined fetal-maternal association of COL5A1 with spontaneous preterm delivery.
Before but not after developing bronchiolitis obliterans, lung transplantation patients had antibodies to Col (zeige HDAC1 Proteine)-V, alpha2(V). Pep5 (zeige VPS11 Proteine)-8 to alpha1,2(V) and pep9-14 to alpha2(V)were immunodominant.
Physical and laboratory examinations revealed that true haploinsufficiency of COL3A1 (zeige COL3A1 Proteine), COL5A2, and MSTN (zeige MSTN Proteine), but not that of SLC40A1 (zeige SLC40A1 Proteine), leads to a clinical phenotype.
Mutations in the COL5A2 gene have been identified by DNA sequence analysis in 10 patients with spontaneous vertebral artery dissections.
analysis of processing of the Pro-alpha1(V)Pro-alpha2(V)Pro-alpha3(V) procollagen heterotrimer
Col5a2 haploinsufficiency markedly increased the incidence and severity of abdominal aortic aneurysms.
Mice with null alleles for the Col5a2. Col5a2(-/-) homozygosity is embryonic lethal at approximately 12 days post conception.
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
alpha 2 type V collagen
, collagen alpha-2(V) chain
, collagen, type V, alpha 2
, collagen, type V, alpha-2 chain
, collagen alpha-2(V) chain-like
, AB collagen
, collagen, fetal membrane, A polypeptide
, type V preprocollagen alpha 2 chain
, procollagen, type V, alpha 2
, collagen type V alpha 2