Collagen, Type IV, alpha 4 (Col4a4) ELISA Kits

Col4a4 encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Zusätzlich bieten wir Ihnen Col4a4 Antikörper (19) und Col4a4 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Col4a4 1286 P53420
Col4a4 12829 Q9QZR9
Anti-Ratte Col4a4 Col4a4 301562  
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Top Col4a4 ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.78 ng/mL 3.12-200 ng/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details
Maus 0.156 ng/mL 0.625-40 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
Details

Weitere ELISA Kits für Col4a4 Interaktionspartner

Human Collagen, Type IV, alpha 4 (Col4a4) Interaktionspartner

  1. Results showed that COL4A4 c.1471C>T and COL4A3 c.3418 + 1G>T variants in cis are pathogenic and co-segregate with the benign familial hematuria. This result suggests that COL4A3 and COL4A4 digenic mutations in cis mimicking an autosomal dominant inheritance should be considered as a novel inheritance pattern of benign familial hematuria.

  2. Three collagen type IV alpha 4 chain (COL4A4) heterozygous mutations that lead to 3 different collagen type IV (zeige COL4 ELISA Kits) kidney disease phenotypes, manifesting as Thin basement membrane nephropathy (TBMN), autosomal dominant Alport syndrome (ADAS (zeige AGPS ELISA Kits)), and focal segmental glomerulosclerosis (FSGS (zeige ACTN4 ELISA Kits)).

  3. For mutation screening, all exons of COL4A3 (zeige COL4a3 ELISA Kits) and COL4A4 genes were polymerase chain reaction-amplified and direct sequenced from genomic DNA, and the mutations were analyzed by comparing with members in this family, 100 ethnicitymatched controls and the sequence of COL4A3 (zeige COL4a3 ELISA Kits) and COL4A4 genes from GenBank. A novel mutation determining a nucleotide change was found, i.e. c.4195 A>T (p.Met1399Leu) at 44th exon of COL4A4 gene.

  4. Two families showed COL4A3 (zeige COL4a3 ELISA Kits)/A4 mutations in cis, mimicking an autosomal dominant inheritance with a more severe phenotype and one showed COL4A3 (zeige COL4a3 ELISA Kits)/A4 mutations in trans, mimicking an autosomal recessive inheritance with a less severe phenotype. In a fourth family, a de novo mutation (COL4A5 (zeige COL4a5 ELISA Kits)) combined with an inherited mutation (COL4A3 (zeige COL4a3 ELISA Kits)) triggered a more severe phenotype

  5. Alport syndrome is the result of mutations in any of three type IV collagen (zeige COL4 ELISA Kits) genes, COL4A3 (zeige COL4a3 ELISA Kits), COL4A4, or COL4A5 (zeige COL4a5 ELISA Kits). Because the three collagen chains form heterotrimers, there is an absence of all three proteins in the basement membranes where they are expressed. (Review)

  6. These findings indicate that the heterozygous mutations in COL4A3 (zeige COL4a3 ELISA Kits) or COL4A4 may cause ESRD on their own, although secondary factors, such as environmental factors or unknown genetic changes, might also contribute to the phenotype of kidney disease in patients with ADAS (zeige AGPS ELISA Kits).

  7. mutations in COL4A3 (zeige COL4a3 ELISA Kits), COL4A4, and COL4A5 (zeige COL4a5 ELISA Kits) in Chinese patients with Alport Syndrome

  8. This finding broadens mutation spectrum of the COL4A4 gene and extends the phenotypic spectrum of collagen IV (zeige COL4 ELISA Kits) nephropathies.

  9. A novel frameshift mutation, c.3213delA (p.Gly1072GlufsFNx0169) in the COL4A4 gene, was identified in the Chinese pedigree with autosomal dominant Alport syndrome

  10. we describe a novel splicing mutation in COL4A4 that results in TBMN. This analysis increases our understanding of TBMN phenotype-genotype correlations, which should facilitate more accurate diagnosis and prenatal diagnosis of TBMN.

Mouse (Murine) Collagen, Type IV, alpha 4 (Col4a4) Interaktionspartner

  1. the NC1 domain of {alpha}3 chain is critical for {alpha}3{alpha}4{alpha}5 type IV collagen (zeige COL4 ELISA Kits) network assembly

  2. Collagen alpha3(IV (zeige COL4a3 ELISA Kits)) nor alpha4(IV) were detected in the lens capsule 2 weeks postnatal.

  3. In kidney, when expressed onto Col4a3 (zeige COL4a3 ELISA Kits)(-/-) background, human alpha3(IV (zeige COL4a3 ELISA Kits)) chain restored expression of and co-assembled with mouse alpha4 and alpha5(IV) chains at sites where human alpha3(IV (zeige COL4a3 ELISA Kits)) was expressed. All three chains required for network assembly.

  4. Alpha3(IV (zeige COL4a3 ELISA Kits)), alpha4(IV), and alpha5(IV) chains form a complex, which is a heterotrimer, and a defect in complex formation might be one of the molecular mechanisms underlying the pathogenesis of Alport syndrome.

Col4a4 Antigen-Profil

Beschreibung des Gens

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. This particular collagen IV subunit, however, is only found in a subset of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Mutations in this gene are associated with type II autosomal recessive Alport syndrome (hereditary glomerulonephropathy) and with familial benign hematuria (thin basement membrane disease). Two transcripts, differing only in their transcription start sites, have been identified for this gene and, as is common for collagen genes, multiple polyadenylation sites are found in the 3' UTR.

Genbezeichner und Symbole assoziert mit Col4a4

  • collagen type IV alpha 4 chain (COL4A4) Antikörper
  • collagen, type IV, alpha 4 (col4a4) Antikörper
  • collagen, type IV, alpha 4 (Col4a4) Antikörper
  • collagen type IV alpha 4 chain (Col4a4) Antikörper
  • CA44 Antikörper
  • E130010M05Rik Antikörper
  • [a]4(IV) Antikörper

Bezeichner auf Proteinebene für Col4a4

collagen alpha-4(IV) chain , collagen type IV alpha 4 chain , collagen, type IV, alpha 4 , alpha 4 type IV collagen , type IV collagen alpha 4 chain , collagen alpha-4(IV) chain-like , Collagen IV, alpha-4 polypeptide , collagen of basement membrane, alpha-4 chain , procollagen, type IV, alpha 4 , alpha type IV collagen basement membrane

GENE ID SPEZIES
403841 Canis lupus familiaris
424799 Gallus gallus
459986 Pan troglodytes
554270 Danio rerio
708287 Macaca mulatta
100073948 Ornithorhynchus anatinus
100388461 Callithrix jacchus
100443710 Pongo abelii
100478914 Ailuropoda melanoleuca
100598507 Nomascus leucogenys
100621403 Sus scrofa
1286 Homo sapiens
12829 Mus musculus
301562 Rattus norvegicus
407107 Bos taurus
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