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CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Zusätzlich bieten wir Ihnen Coiled-Coil and C2 Domain Containing 1A Antikörper (48) und Coiled-Coil and C2 Domain Containing 1A Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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Both expressions of CC2D1A and HTR1A (zeige HTR1A Proteine) genes studied on autism spectrum disorder cases and controls were significantly different
CC2D1A binds to CHMP4B (zeige CHMP4A Proteine) polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR (zeige EGFR Proteine) and TLR4 (zeige TLR4 Proteine).
Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1 (zeige CREB1 Proteine). Aki1 regulates CREB (zeige CREB1 Proteine) by modulating protein kinase A activity. The Aki1-CREB (zeige CREB1 Proteine) axis plays an important role in DMM (zeige COL2A1 Proteine) pathogenesis.
Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD (zeige ARSD Proteine), and seizures. CC2D1A regulates NF-kappaB (zeige NFKB1 Proteine) signaling.
All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt (zeige AKT1 Proteine) and increased the phosphorylation of cleaved PARP.
Non-genomic downregulation of 5-HT1A receptor (zeige HTR1A Proteine) by 17betaestradiol does not involve NUDR (zeige DEAF1 Proteine) and Freud-1 proteins.
TBK1 (zeige TBK1 Proteine)-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I (zeige DDX58 Proteine)-like receptors to antiviral immunity
CHMP4B (zeige CHMP4A Proteine) interacts directly with CC2D1A and CC2D1B (zeige CC2D1B Proteine) with nanomolar affinity by forming a 1:1 complex.
CC2D1A interaction with CHMP4B (zeige CHMP4A Proteine)/4A blocks HIV-1 budding.
Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.
Cc2d1a conditional knockout mice therefore recapitulate features of both cognitive and social impairment caused by human CC2D1A mutation
Freud-1 is crucial for 5-HT1A (zeige HTR1A Proteine) autoreceptor expression and links up-regulation of 5-HT1A (zeige HTR1A Proteine) autoreceptors to anxiety/depression-like behavior.
CC2D1A and CC2D1B (zeige CC2D1B Proteine) role and function in the endocytic pathway and Notch (zeige NOTCH1 Proteine) signalling.
Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses.
Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A (zeige HTR1A Proteine)) receptor transcriptional regulation.
Freud-1 has a key role in regulating DRD2 (zeige DRD2 Proteine) expression
Paper describes a function of Cc2d1a/Cc2d1b (zeige CC2D1B Proteine) and its Drosophila homologue l(2)gd in D.melanogaster in Notch (zeige NOTCH1 Proteine) trafficking.
Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression.
This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.
coiled-coil and C2 domain containing 1A
, coiled-coil and C2 domain-containing protein 1A
, coiled-coil and C2 domain-containing protein 1A-like
, Akt kinase-interacting protein 1
, FRE under dual repression-binding protein 1
, five prime repressor element under dual repression-binding protein 1
, five repressor element under dual repression-binding protein 1
, mental retardation, nonsyndromic, autosomal recessive, 3
, putative NF-kappa-B-activating protein 023N
, putative NFkB activating protein
, 5-HT1A receptor
, five' repressor element under dual repression binding protein 1