Coiled-Coil and C2 Domain Containing 1A Proteine (CC2D1A)

CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Zusätzlich bieten wir Ihnen Coiled-Coil and C2 Domain Containing 1A Antikörper (47) und Coiled-Coil and C2 Domain Containing 1A Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CC2D1A 54862 Q6P1N0
CC2D1A 212139 Q8K1A6
Ratte CC2D1A CC2D1A 288908 Q66HA5
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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CC2D1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaktionspartnern

Human Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaktionspartner

  1. Both expressions of CC2D1A and HTR1A (zeige HTR1A Proteine) genes studied on autism spectrum disorder cases and controls were significantly different

  2. CC2D1A binds to CHMP4B (zeige CHMP4A Proteine) polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR (zeige EGFR Proteine) and TLR4 (zeige TLR4 Proteine).

  3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1 (zeige CREB1 Proteine). Aki1 regulates CREB (zeige CREB1 Proteine) by modulating protein kinase A activity. The Aki1-CREB (zeige CREB1 Proteine) axis plays an important role in DMM (zeige COL2A1 Proteine) pathogenesis.

  4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD (zeige ARSD Proteine), and seizures. CC2D1A regulates NF-kappaB (zeige NFKB1 Proteine) signaling.

  5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt (zeige AKT1 Proteine) and increased the phosphorylation of cleaved PARP.

  6. Non-genomic downregulation of 5-HT1A receptor (zeige HTR1A Proteine) by 17betaestradiol does not involve NUDR (zeige DEAF1 Proteine) and Freud-1 proteins.

  7. TBK1 (zeige TBK1 Proteine)-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I (zeige DDX58 Proteine)-like receptors to antiviral immunity

  8. CHMP4B (zeige CHMP4A Proteine) interacts directly with CC2D1A and CC2D1B (zeige CC2D1B Proteine) with nanomolar affinity by forming a 1:1 complex.

  9. CC2D1A interaction with CHMP4B (zeige CHMP4A Proteine)/4A blocks HIV-1 budding.

  10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.

Mouse (Murine) Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaktionspartner

  1. Cc2d1a conditional knockout mice therefore recapitulate features of both cognitive and social impairment caused by human CC2D1A mutation

  2. Freud-1 is crucial for 5-HT1A (zeige HTR1A Proteine) autoreceptor expression and links up-regulation of 5-HT1A (zeige HTR1A Proteine) autoreceptors to anxiety/depression-like behavior.

  3. CC2D1A and CC2D1B (zeige CC2D1B Proteine) role and function in the endocytic pathway and Notch (zeige NOTCH1 Proteine) signalling.

  4. TBK1 (zeige TBK1 Proteine)-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I (zeige DDX58 Proteine)-like receptors to antiviral immunity

  5. Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses.

  6. Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A (zeige HTR1A Proteine)) receptor transcriptional regulation.

  7. Freud-1 has a key role in regulating DRD2 (zeige DRD2 Proteine) expression

  8. Paper describes a function of Cc2d1a/Cc2d1b (zeige CC2D1B Proteine) and its Drosophila homologue l(2)gd in D.melanogaster in Notch (zeige NOTCH1 Proteine) trafficking.

  9. Novel calcium-regulated repressor that negatively regulates basal 5-HT1A receptor expression.

Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Protein Überblick

Protein Überblick

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Genbezeichner und Symbole assoziert mit CC2D1A

  • coiled-coil and C2 domain containing 1A (CC2D1A)
  • coiled-coil and C2 domain containing 1A (cc2d1a)
  • coiled-coil and C2 domain containing 1A (Cc2d1a)
  • BC016188 Protein
  • Freud-1 Protein
  • Freud-1/Aki1 Protein
  • MRT3 Protein
  • RGD1306108 Protein
  • Tape Protein

Bezeichner auf Proteinebene für CC2D1A

coiled-coil and C2 domain containing 1A , coiled-coil and C2 domain-containing protein 1A , coiled-coil and C2 domain-containing protein 1A-like , Akt kinase-interacting protein 1 , FRE under dual repression-binding protein 1 , five prime repressor element under dual repression-binding protein 1 , five repressor element under dual repression-binding protein 1 , mental retardation, nonsyndromic, autosomal recessive, 3 , putative NF-kappa-B-activating protein 023N , putative NFkB activating protein , 5-HT1A receptor , five' repressor element under dual repression binding protein 1 , freud-1

GENE ID SPEZIES
468744 Pan troglodytes
484911 Canis lupus familiaris
513078 Bos taurus
718483 Macaca mulatta
100020918 Monodelphis domestica
100145460 Xenopus (Silurana) tropicalis
100482182 Ailuropoda melanoleuca
100603711 Nomascus leucogenys
54862 Homo sapiens
212139 Mus musculus
288908 Rattus norvegicus
100712639 Cavia porcellus
101119902 Ovis aries
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