Coiled-Coil and C2 Domain Containing 1A Proteine (CC2D1A)

CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Zusätzlich bieten wir Ihnen Coiled-Coil and C2 Domain Containing 1A Antikörper (48) und Coiled-Coil and C2 Domain Containing 1A Kits (18) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CC2D1A 54862 Q6P1N0
CC2D1A 212139 Q8K1A6
Ratte CC2D1A CC2D1A 288908 Q66HA5
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
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CC2D1A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaktionspartnern

Human Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Interaktionspartner

  1. Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different

  2. CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4.

  3. Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis.

  4. Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling.

  5. All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP.

  6. Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins.

  7. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity

  8. CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex.

  9. CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding.

  10. Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.

  11. Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder.

  12. Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy.

  13. central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step

  14. CC2D1A activates NF-kappaB through the canonical IKK pathway

  15. these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function.

  16. Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion.

  17. A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation.

  18. a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains.

  19. Freud-1 has a key role in regulating DRD2 expression

  20. disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation

Coiled-Coil and C2 Domain Containing 1A (CC2D1A) Protein Überblick

Protein Überblick

This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.

Genbezeichner und Symbole assoziert mit CC2D1A

  • coiled-coil and C2 domain containing 1A (CC2D1A)
  • coiled-coil and C2 domain containing 1A (cc2d1a)
  • coiled-coil and C2 domain containing 1A (Cc2d1a)
  • BC016188 Protein
  • Freud-1 Protein
  • Freud-1/Aki1 Protein
  • MRT3 Protein
  • RGD1306108 Protein
  • Tape Protein

Bezeichner auf Proteinebene für CC2D1A

coiled-coil and C2 domain containing 1A , coiled-coil and C2 domain-containing protein 1A , coiled-coil and C2 domain-containing protein 1A-like , Akt kinase-interacting protein 1 , FRE under dual repression-binding protein 1 , five prime repressor element under dual repression-binding protein 1 , five repressor element under dual repression-binding protein 1 , mental retardation, nonsyndromic, autosomal recessive, 3 , putative NF-kappa-B-activating protein 023N , putative NFkB activating protein , 5-HT1A receptor , five' repressor element under dual repression binding protein 1 , freud-1

GENE ID SPEZIES
468744 Pan troglodytes
484911 Canis lupus familiaris
513078 Bos taurus
718483 Macaca mulatta
100020918 Monodelphis domestica
100145460 Xenopus (Silurana) tropicalis
100482182 Ailuropoda melanoleuca
100603711 Nomascus leucogenys
54862 Homo sapiens
212139 Mus musculus
288908 Rattus norvegicus
100712639 Cavia porcellus
101119902 Ovis aries
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