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CC2D1A encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. Zusätzlich bieten wir Ihnen Coiled-Coil and C2 Domain Containing 1A Antikörper (48) und Coiled-Coil and C2 Domain Containing 1A Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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Both expressions of CC2D1A and HTR1A genes studied on autism spectrum disorder cases and controls were significantly different
CC2D1A binds to CHMP4B polymers formed on endosomes to regulate the endosomal sorting pathway.CC2D1A regulates degradation and signaling of EGFR and TLR4.
Aki1 was expressed in human diffuse malignant mesothelioma specimens. Expression correlated with phosphorylated CREB1. Aki1 regulates CREB by modulating protein kinase A activity. The Aki1-CREB axis plays an important role in DMM pathogenesis.
Null mutations in CC2D1A consistently cause a variable spectrum of presentations including ID, ASD, and seizures. CC2D1A regulates NF-kappaB signaling.
All of the pancreatic cancer cell lines expressed Aki1. Silencing of Aki1 in Panc1 cells reduced the phosphorylation of Akt and increased the phosphorylation of cleaved PARP.
Non-genomic downregulation of 5-HT1A receptor by 17betaestradiol does not involve NUDR and Freud-1 proteins.
TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity
CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex.
CC2D1A interaction with CHMP4B/4A blocks HIV-1 budding.
Results suggest the involvement of CC2D1A and CC2D2A in mental retardation in the Han Chinese population, and some specific haplotypes may be susceptible or protective.
Reductions in Freud-1 expression in prefrontal cortex may be associated with early onset of major depressive disorder.
Data suggest that the anti-tumor activity of NF-kappaB inhibitors is associated with p53-mediated activation of autophagy.
central role for TAPE (CC2D1A/Freud-1/Aki-1)in linking TLR3 and TLR4 to innate immune defenses at an early step
CC2D1A activates NF-kappaB through the canonical IKK pathway
these results indicate that cyclin B1-Cdk1 is a kinase of Aki1 during mitosis and that its phosphorylation of Aki1 may regulate mitotic function.
Centrosome-associated Aki1 and cohesin play pivotal roles in preventing premature cleavage in centriole cohesion.
A protein truncating mutation was identified in the gene CC2D1A in nine consanguineous families with severe autosomal recessive mental retardation.
a deletion in the CC2D1A gene has been linked to nonsyndromic mental retardation. This deletion results in the truncation of the helix-loop-helix DNA binding and the C2 domains.
Freud-1 has a key role in regulating DRD2 expression
disruption of transcriptional regulation by mutation of Freud-1 may play a role in abnormal brain function leading to mental retardation
This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3.
coiled-coil and C2 domain containing 1A
, coiled-coil and C2 domain-containing protein 1A
, coiled-coil and C2 domain-containing protein 1A-like
, Akt kinase-interacting protein 1
, FRE under dual repression-binding protein 1
, five prime repressor element under dual repression-binding protein 1
, five repressor element under dual repression-binding protein 1
, mental retardation, nonsyndromic, autosomal recessive, 3
, putative NF-kappa-B-activating protein 023N
, putative NFkB activating protein
, 5-HT1A receptor
, five' repressor element under dual repression binding protein 1