Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) ELISA Kits

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. Zusätzlich bieten wir Ihnen Cleavage and Polyadenylation Specific Factor 4, 30kDa Antikörper (68) und Cleavage and Polyadenylation Specific Factor 4, 30kDa Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
Anti-Ratte CPSF4 CPSF4 100360200  
Anti-Maus CPSF4 CPSF4 54188 Q8BQZ5
Anti-Human CPSF4 CPSF4 10898 O95639
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Weitere ELISA Kits für Cleavage and Polyadenylation Specific Factor 4, 30kDa Interaktionspartner

Human Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Interaktionspartner

  1. Residues F103 and M106 within the NS1 (zeige PTPN11 ELISA Kits)-CPSF4 binding region are important for viral replication.

  2. Cleavage and polyadenylation specific factor 4 targets NF-kappaB (zeige NFKB1 ELISA Kits)/cyclooxygenase-2 (zeige PTGS2 ELISA Kits) signaling to promote the growth and survival of non-small cell lung carcinoma cells.

  3. These findings support a role for iron in some zinc-finger proteins. Using electrophoretic mobility shift assays and fluorescence anisotropy, we report that CPSF30 selectively recognizes the AU-rich hexamer (AAUAAA) sequence present in pre-mRNA, providing the first molecular-based evidence to our knowledge for CPSF30/RNA binding.

  4. unexpectedly found that CPSF subunits CPSF30 and Wdr33 directly contact AAUAAA

  5. CPSF4 upregulates human TERT (zeige TERT ELISA Kits) promoter activity, human TERT (zeige TERT ELISA Kits) expression and telomerase activity.

  6. Data show that 4 drug-like compounds from traditional Chinese Medicine (TCM) database were selected as potential inhibitors for the cleavage and polyadenylation specific factor CPSF30-binding site of influenza A virus of non-structural protein 1 (NS1A).

  7. CPSF4 plays a critical role in regulating lung cancer cell proliferation and survival and may be a potential prognostic biomarker and therapeutic target for lung adenocarcinoma.

  8. Data show that the NS1A protein of the pathogenic H5N1 influenza A/Hong Kong/483/97 (HK97) virus isolated from humans has an intrinsic defect in CPSF30 binding.

Cleavage and Polyadenylation Specific Factor 4, 30kDa (CPSF4) Antigen-Profil

Beschreibung des Gens

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit CPSF4

  • cleavage and polyadenylation specific factor 4 (CPSF4) Antikörper
  • cleavage and polyadenylation specific factor 4, 30kDa (Cpsf4) Antikörper
  • cleavage and polyadenylation specific factor 4 (LOC733099) Antikörper
  • cleavage and polyadenylation specific factor 4 (LOC100360200) Antikörper
  • cleavage and polyadenylation specific factor 4 S homeolog (cpsf4.S) Antikörper
  • cleavage and polyadenylation specific factor 4 (cpsf4) Antikörper
  • cleavage and polyadenylation specific factor 4 (Cpsf4) Antikörper
  • 30kDa Antikörper
  • C79664 Antikörper
  • CPSF30 Antikörper
  • NAR Antikörper
  • NEB1 Antikörper

Bezeichner auf Proteinebene für CPSF4

no arches , GLEAN_10339 , cleavage and polyadenylation specific factor 4 , cleavage and polyadenylation specificity factor subunit 4 , cleavage and polyadenylation specific factor 4, 30kDa , CPSF 30 kDa subunit , cleavage and polyadenylation specific factor 4, 30kD subunit , cleavage and polyadenylation specificity factor 30 kDa subunit , clipper homolog , clipper/CPSF 30K , musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit , NS1 effector domain-binding protein 1 , cleavage-polyadenylation specificity factor, 30kD , neb-1 , no arches homolog , no arches-like zinc finger protein , cleavage-polyadenylation specificity factor, 30 kD

GENE ID SPEZIES
463572 Pan troglodytes
660072 Tribolium castaneum
733099 Bombyx mori
100360200 Rattus norvegicus
444766 Xenopus laevis
493312 Xenopus (Silurana) tropicalis
708119 Macaca mulatta
100224162 Taeniopygia guttata
54188 Mus musculus
304277 Rattus norvegicus
10898 Homo sapiens
416494 Gallus gallus
489859 Canis lupus familiaris
280875 Bos taurus
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