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May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Zusätzlich bieten wir Ihnen Cleavage Stimulation Factor, 3' Pre-RNA, Subunit 2, 64kDa, tau Variant Antikörper (40) und und viele weitere Produktgruppen zu diesem Protein an.
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Cstf2t Polyadenylation Gene Plays a Sex-Specific Role in Learning Behaviors in Mice
This demonstrates that tauCstF-64 is an important stage-specific regulator of Crem mRNA processing that modulates the spatial and temporal expression of downstream stage-specific genes necessary for the proper development of sperm in mice.
The results suggest that tauCstF-64 plays a role in 3' end determination and transcription termination for a large range of germ cell-expressed genes.
primarily supports spermatogenesis, but only incidently supports immune cell function
tauCstF-64 is required not only for expression of genes involved in morphological differentiation of spermatids but also for genes having products that function during interaction of motile spermatozoa with eggs.
physiologically increased levels of CstF-64 observed in LPS-stimulated RAW macrophages contribute to the changes in expression and alternative polyadenylation of a number of genes
These results suggest the hypothesis that tauCstF-64 mRNA is regulated at the translational or post-translational level.
tauCstF-64 promotes germ-cell-specific patterns of polyadenylation by binding to different downstream sequence elements.
Targeted disruption of Cstf2t in mice causes aberrant spermatogenesis, specifically disrupting meiotic and postmeiotic development, resulting in male infertility resembling oligoasthenoteratozoospermia.
The Cstf2t protein contributes to proteomic diversity by regulating alternative polyadenylation of neural mRNAs.
CSTF2tau binds many previously not recognized RNAs including histone, snoRNA and snRNAs. CSTF2tau-binding is associated with internal oligoadenylation resulting in shortened snRNA isoforms subjected to rapid degradation. CSTF2tau controls the abundance of snRNAs resulting in alternative splicing of several RNAs with critical roles in tumorigenesis and cardiac function.
CstF64 and CstF64tau modulate one another's expression and play overlapping as well as distinct roles in regulating global alternative polyadenylation profiles.
Studied expression levels of CstF-64 in EV71-infected cells; showed reduction of CstF-64 during virus infection correlated with production of viral 3C(pro). CstF-64 was cleaved in vitro by 3C(pro) not by mutant 3C(pro) variants.
Radiation hybrid mapping places the human tauCstF-64 gene at 10q22-q23, which is the site of a translocation that has been associated with human neurological problems and male infertility.
structure of the RNA-binding domain of CstF-64 containing an RNA recognition motif (RRM) augmented by N- and C-terminal helices
upstream element in human papillomavirus type 16 interacted specifically with CstF-64, hnRNP C1/C2 & polypyrimidine tract binding protein, suggesting these factors were enhancing or regulating polyadenylation at the HPV-16 early polyadenylation signal
May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
CF-1 64 kDa subunit tau
, CF-1 64 kDa subunit, tau
, CSTF 64 kDa subunit tau
, CSTF 64 kDa subunit, tau
, cleavage stimulation factor 64 kDa subunit tau
, cleavage stimulation factor 64 kDa subunit, tau
, cleavage stimulation factor subunit 2 tau
, cleavage stimulation factor subunit 2 tau variant
, cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa, tau
, cleavage stimulation factor, 3' pre-RNA subunit 2, tau