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CIITA expression is higher when carried by FP single recombinants than when combined with FPgp or FPenv constructs and can induce HLA-DR cell surface expression. However, in-vivo experiments did not show any significant increase in the humoral response. As CIITA already proved to elicit immunogenicity by improving antigen presentation, further in-vivo experiments should be performed to increase the immune responses
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Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription.
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B. abortus lipoproteins via IL-6 inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA induction.
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Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC implantation on myocardial repair.
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Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison.
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CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to NPC risk and provide novel biological insights into NPC pathogenesis.
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When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased
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the MHC2TA -168 A/G polymorphism is not associated with susceptibility to rheumatoid arthritis in Caucasians [meta-analysis]
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Observed no association between the MHC2TA or FCRL3 SNPs and rheumatoid arthritis in Mexican patients.
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CIITA acts as a general restriction factor against HIV-1 not only in T cells but also in myeloid cells.
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CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma.
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CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins.
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The dimerization region of Epstein-Barr virus Zta is not required to mediate host CIITA repression.
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Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1-mediated NF-kappaB activation.
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FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74.
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Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.
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Genomic alterations underlying immune privilege in malignant lymphomas prominently include structural genomic changes of the CIITA and CD274 loci. (Review)
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19S ATPases have nonproteolytic roles in transcription of CIITApIV genes
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The negative expression of CIITA protein was the key reason for the loss of MHC II expression in HL60 cells.
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two DNA-binding proteins, which interact with and regulate PRC2 recruitment to CIITA promoter IV, were identified.