Citron (Rho-Interacting, serine/threonine Kinase 21) Proteine (CIT)

CIT encodes a serine/threonine-protein kinase that functions in cell division. Zusätzlich bieten wir Ihnen CIT Antikörper (47) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte CIT CIT 83620  
Maus CIT CIT 12704  
CIT 11113 O14578
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 11 bis 12 Tage
$560.00
Details
Escherichia coli (E. coli) Human His tag   500 μg Anmelden zum Anzeigen 2 bis 3 Tage
$1,719.38
Details
Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 10 bis 12 Tage
$365.64
Details
Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 3 bis 4 Tage
$360.00
Details

CIT Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
,

Weitere Proteine zu Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) Interaktionspartnern

Mouse (Murine) Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) Interaktionspartner

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  3. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

  4. p27 (zeige CDKN1B Proteine) has a role in cytokinesis via the regulation of citron-K activity

  5. CITRON has a role in proliferation of hepatocellular carcinoma cells

  6. Data report that Discs large (zeige DLG4 Proteine) 5 (Dlg5 (zeige DLG5 Proteine)), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.

  7. Citron-K has a distinct cell cycle-dependent expression pattern and cellular localization as a downstream target of Rho-GTPase (zeige RACGAP1 Proteine) and functions in the control of G(2)/M transition in the hepatocyte cell cycle

  8. Quantitative analysis of citron kinase in cerebral cortex of knockout mice demonstrates that this molecule is involved in differentially regulating the morphology of the dendritic compartment in corticocollicular projecting pyramidal neurons.

  9. These results suggest that the TTC3-RhoA (zeige RHOA Proteine)-CIT-K pathway could be a crucial determinant of in vivo neuronal development, whose hyperactivity may result in detrimental effects on the normal differentiation program.

  10. Lack of citron kinase gene in newborn mice profoundly alters barrelfield cortex cell morphology and number.

Human Citron (Rho-Interacting, serine/threonine Kinase 21) (CIT) Interaktionspartner

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. Control of abscission requires Eph (zeige EPHA1 Proteine) kinase activity, and Src (zeige SRC Proteine) and citron kinase (CitK) are downstream effectors in the Eph (zeige EPHA1 Proteine)-induced signal transduction cascade

  3. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.

  4. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.

  5. Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly

  6. identification of recessively inherited pathogenic variants in CIT as the genetic basis of severe microcephaly and neonatal death; and postmortem data showing that CIT is critical to building a normally sized human brain

  7. The CIT-K may promote this event by interacting with TUBB3 and by recruiting at the midbody casein kinase-2alpha (CK2alpha) that has previously been reported to phosphorylate the S444 residue.

  8. Proper midbody architecture requires cross-regulation between two cell division kinases, Citron kinase (CIT-K) and Aurora B (zeige AURKB Proteine), the kinase component of the chromosomal passenger complex.

  9. The TPC1 was shown to interact with citron kinase, with TPC1 overexpression affecting RhoA activity and myosin light chain phosphorylation levels in cytokinesis.

  10. Data propose that the CC-domain-mediated translocation and actions of Citron-K ensure proper stabilization of the midbody structure during the transition from constriction to abscission.

CIT Protein Überblick

Protein Überblick

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit CIT

  • citron rho-interacting serine/threonine kinase (Cit)
  • citron rho-interacting serine/threonine kinase (CIT)
  • citron (rho-interacting, serine/threonine kinase 21) (CIT)
  • citron Rho-interacting kinase (LOC100083347)
  • citron rho-interacting serine/threonine kinase (cit)
  • citron (Cit)
  • C030025P15Rik Protein
  • CIT Protein
  • Cit-k Protein
  • CRIK Protein
  • CRIK-SK Protein
  • STK21 Protein
  • xcit Protein

Bezeichner auf Proteinebene für CIT

citron Rho-interacting kinase , citron kinase , citron-K kinase , postsynaptic density protein (citron) , citron (rho-interacting, serine/threonine kinase 21) , citron-N , rho-interacting, serine/threonine-protein kinase 21 , serine/threonine-protein kinase 21

GENE ID SPEZIES
83620 Rattus norvegicus
416984 Gallus gallus
452298 Pan troglodytes
695846 Macaca mulatta
786852 Bos taurus
100050621 Equus caballus
100083347 Ornithorhynchus anatinus
100145758 Xenopus (Silurana) tropicalis
100153706 Sus scrofa
100348177 Oryctolagus cuniculus
100544730 Meleagris gallopavo
100553665 Anolis carolinensis
12704 Mus musculus
11113 Homo sapiens
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