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Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Zusätzlich bieten wir Ihnen Chromosome 6 Open Reading Frame 134 Antikörper (38) und viele weitere Produktgruppen zu diesem Protein an.
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these results demonstrate alphaTAT1 enters the lumen of microtubules from open extremities and spreads K40 acetylation marks longitudinally along cellular microtubules; this mode of tip-directed microtubule acetylation may allow for selective acetylation of subsets of microtubules
Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage.
cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 (zeige MYH9 Proteine) and initiates ciliogenesis
These results suggest that alphaTAT1-mediated Wnt1 (zeige WNT1 Proteine) expression via microtubule acetylation is important for colon cancer progression.
Studies indicate that alpha-tubulin (zeige TUBA4A Proteine) acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6 (zeige HDAC6 Proteine)).
Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia.
Data suggest that invariant residues Arg132 and Ser160 in catalytic domain of ATAT1 participate in stable interaction with CoA and acetyl-CoA (zeige LPCAT2 Proteine); ATAT1 with mutation at either residue exhibits much faster intracellular degradation.
Crystal structure of the catalytic core of human MEC-17 in complex with acetyl-CoA (zeige LPCAT2 Proteine). MEC17 has large, conserved surface patch that is critical for enzymatic activity suggesting extensive interactions with alpha-tubulin (zeige TUBA4A Proteine).
Mechanistic underpinnings for TAT (zeige TAT Proteine) activity and its preference for microtubules with slow turnover; cocrystal structures constrain TAT (zeige TAT Proteine) action to the microtubule lumen with Lys40 engaged in a suboptimal active site; despite the confined location of Lys40, TAT (zeige TAT Proteine) efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends.
microtubules contacting clathrin-coated pits become acetylated by alphaTAT1; in migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis
Crystal structures of tubulin acetyltransferase reveal a conserved catalytic core and the plasticity of the essential N terminus.
Atat1 knockdown resulted in a significant increase in the expression of ACTH (zeige POMC Proteine)-producing genes and decreased the dexamethasone-induced nuclear translocation of glucocorticoid receptor (zeige NR3C1 Proteine) accompanied with a reduction in alpha-tubulin (zeige TUBA4A Proteine) acetylation.
Here the authors demonstrate that mice lacking the alpha-tubulin (zeige TUBA4A Proteine) acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli.
alphaTAT1 has a conserved function as the major alpha-tubulin acetyltransferase in ciliated organisms and has an important role in regulating subcellular specialization of subsets of microtubules.
Data indicate that alpha-tubulin acetyltransferase 1 Atat1 is not required for survival and development but may regulate more advanced functions.
Acetylation of alpha-tubulin (zeige TUBA4A Proteine) is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2 (zeige SIRT2 Proteine)) and HDAC6 (histone deacetylase 6 (zeige HDAC6 Proteine)). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells.
Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development (By similarity).
acetyltransferase mec-17 homolog
, alpha-tubulin N-acetyltransferase
, MEChanosensory abnormality homolog
, Novel DUF738 containing protein (2610110G12Rik)
, alpha-tubulin N-acetyltransferase 1