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Plays a role in the trafficking of mitochondria along microtubules. Zusätzlich bieten wir Ihnen Chromosome 4 Open Reading Frame 49 Antikörper (27) und und viele weitere Produktgruppen zu diesem Protein an.
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The ratio of motile mitochondria was remarkably decreased in the axons of MGARP-overexpressing cells.
These results indicate that HUMMR does not play a key role in mitochondrial dysfunction in the APP/PS1 double transgenic Alzheimer disease mouse
MGARP participates in hormone biosynthesis while being under the regulation of the hormones derived from the hypothalamic-pituitary-gonadal axis.
Results identify a mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) as one of the highly expressed proteins in retina [MGARP].
HUMMR (Hypoxia Upregulated Mitochondrial Movement Regulator) is induced by HIF-1 and regulates mitochondrial distribution and movement in neurons during hypoxia
OSAP is prominently expressed in steroidogenic tissues; results suggest that OSAP is involved in steroidogenesis, potentially through its ability to maintain mitochondrial abundance and morphology
The present study identified a proximal core sequence in the MGARP promoter that is composed of two enriched Sp1 binding motifs and established Sp1 as one major MGARP transactivator.
Results identify a novel mitochondria protein, hypoxia up-regulated mitochondrial movement regulator (HUMMR), which is expressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha).
Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity).
corneal endothelium-specific protein 1
, hypoxia up-regulated mitochondrial movement regulator protein
, mitochondria-localized glutamic acid-rich protein
, ovary-specific acidic protein
, protein MGARP
, hypoxia up-regulated mitochondrial movement regulator