Chromosome 19 Open Reading Frame 40 Proteine (C19ORF40)

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen Chromosome 19 Open Reading Frame 40 Antikörper (10) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
C19ORF40 91442 Q9BTP7
C19ORF40 101831 Q8BHL6
C19ORF40 510793 Q2KHY5
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Top Chromosome 19 Open Reading Frame 40 Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,531.83
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C19ORF40 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Cow (Bovine)

Weitere Proteine zu Chromosome 19 Open Reading Frame 40 (C19ORF40) Interaktionspartnern

Human Chromosome 19 Open Reading Frame 40 (C19ORF40) Interaktionspartner

  1. This is the first report of an FAAP24 loss of function mutation found in human patients with EBV-associated lymphoproliferation (zeige FAS Proteine).

  2. These results demonstrate dual roles of FAAP24 in DNA damage response against crosslinking lesions, one through the formation of FANCM/FAAP24 heterodimer and the other via its ssDNA-binding activity required in optimized checkpoint activation.

  3. Crystal structure of the FANCM-FAAP24 complex.

  4. Results show that the first HhH (zeige SLC25A15 Proteine) motif of FAAP24 is a potential binding site for DNA, which plays a critical role in targeting FANCM-FAAP24 to chromatin.

  5. FANCM and FAAP24 play multiple, while not fully epistatic, roles in maintaining genomic integrity.

  6. FANCM/FAAP24 plays a role in ICL-induced checkpoint activation through regulating RPA recruiment at ICL-stalled replication forks.

  7. FAAP24 targets FANCM to structures that mimic intermediates formed during the replication/repair of damaged DNA.

  8. FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity

  9. FAAP24 is dispensable for DNA binding and branch migration activity of FANCM.

  10. DNA damage recognition and remodeling activities of FANCM and FAAP24 cooperate to promote efficient activation of DNA damage checkpoints in Fanconi anemia (zeige PALB2 Proteine).

Chromosome 19 Open Reading Frame 40 (C19ORF40) Protein Überblick

Protein Überblick

FAAP24 is a component of the Fanconi anemia (FA) core complex (see MIM 227650), which plays a crucial role in DNA damage response (Ciccia et al., 2007

Genbezeichner und Symbole assoziert mit C19ORF40

  • Fanconi anemia core complex associated protein 24 (FAAP24)
  • Fanconi anemia core complex associated protein 24 (Faap24)
  • AW124591 Protein
  • AW538696 Protein
  • Faap24 Protein

Bezeichner auf Proteinebene für C19ORF40

Fanconi anemia-associated protein of 24 kDa , Fanconi anemia-associated protein, 24 kDa

GENE ID SPEZIES
510793 Bos taurus
91442 Homo sapiens
101831 Mus musculus
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