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C19orf2 encodes member of the prefoldin family of molecular chaperones. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Collectively, these findings indicate that RMP (zeige ABCA4 Antikörper) promotes Epithelial-mesenchymal transition and hepatocellular carcinoma metastasis through NF-kappaB (zeige NFKB1 Antikörper)/CSN2 (zeige CSN2 Antikörper)/Snail (zeige SNAI1 Antikörper) pathway. These results suggest that RMP (zeige ABCA4 Antikörper) and p65 (zeige GORASP1 Antikörper) may serve as potential candidates of the targets in the treatment of metastatic hepatocellular carcinoma.
These findings suggest that URI1 has properties of a 'non-oncogene (zeige RAB1A Antikörper)' that supports the oncogenic phenotype of those cancer cells that have evolved a dependency on this molecular chaperone (zeige HSP90AA1 Antikörper) system for survival
This work uncovers that URI-regulated OGT (zeige OGT Antikörper) confers c-MYC (zeige MYC Antikörper)-dependent survival functions in response to glucose fluctuations.
Amplification of 19q12 CCNE1 (zeige CCNE1 Antikörper)/URI was found in 10.4% (28/270) and was significantly associated with type II endometrial cancer (EC) high grade, advanced FIGO stage, and aberrant tumor supressor p53 (zeige TP53 Antikörper) expression.
that KAP1 (zeige CDKN3 Antikörper) phosphorylation is decreased following recruitment of PP2A (zeige PPP2R4 Antikörper) by URI.
RMP (zeige ABCA4 Antikörper) status in tumors may be a useful marker in estimating prognosis in patients with hepatocellular carcinoma and in assisting in the selection of patients who are likely to benefit from adjuvant TACE (zeige ADAM17 Antikörper) to prevent relapse.
High URI1 expression is associated with epithelial ovarian cancer.
Results show that URI expression is essential for hepatocarcinogenesis and associated with poor survival.
URI may have an important role in the development of multiple myeloma and chemotherapeutic resistance through activation of the IL-6 (zeige IL6 Antikörper)/STAT3 (zeige STAT3 Antikörper) pathway.
Higher level of URI/RMP expression in high-grade endometrioid adenocarcinomas compared to tissues of adjacent endometrium or gland suggests a diagnostic and possibly, a prognostic value of URI/RMP in endometrioid adenocarcinoma.
Results show that RMP (zeige ABCA4 Antikörper) serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 (zeige IL6 Antikörper) transcription.
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.
chromosome 19 open reading frame 2
, RNA polymerase II subunit 5-mediating protein
, RPB5-mediating protein
, protein phosphatase 1 regulatory subunit 19
, protein phosphatase 1, regulatory subunit 19
, unconventional prefoldin RPB5 interactor 1
, unconventional prefoldin RPB5 interactor