Chromosome 14 Open Reading Frame 169 Proteine (C14orf169)

Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Zusätzlich bieten wir Ihnen C14orf169 + NO66 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
C14orf169 79697 Q9H6W3
C14orf169 71952 Q9JJF3
Ratte C14orf169 C14orf169 314300 D3ZU57
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Top C14orf169 + NO66 Proteine auf antikoerper-online.de

Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
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C14orf169 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Chromosome 14 Open Reading Frame 169 (C14orf169) Interaktionspartnern

Cow (Bovine) Chromosome 14 Open Reading Frame 169 (C14orf169) Interaktionspartner

  1. PHF19 (zeige PHF19 Proteine) associates with the H3K36me3 demethylase (zeige MBD2 Proteine) NO66, and it is required to recruit the PRC2 complex and NO66 to stem cell genes during differentiation

Human Chromosome 14 Open Reading Frame 169 (C14orf169) Interaktionspartner

  1. our findings clearly indicated that epigenetic regulation by NO66 plays an important role in cancer metastatic processes in CRC (zeige CALR Proteine).

  2. Results show that high expression levels of SMYD2, SETD3 (zeige SETD3 Proteine), and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival.

  3. confirmed the hydroxylase activity of NO66 and showed that oligomerization is required for NO66 to efficiently catalyze the hydroxylation of Rpl8 (zeige RPL8 Proteine)

  4. hinge domain-dependent oligomerization of NO66 is essential for inhibition of Osx (zeige MID1 Proteine)-dependent gene activation.

  5. NO66 crystallized in space group P3(1) or P3(2), with unit-cell parameters a = 89.35, b = 89.35, c = 304.86 A, alpha = beta = 90, gamma = 120 degrees , and the crystal is likely to contain four molecules in the asymmetric unit

  6. interactions between NO66 and Osx (zeige MID1 Proteine) regulate Osx (zeige MID1 Proteine)-target genes in osteoblasts by modulating histone methylation states

  7. NO66 has functions in ribosome biogenesis and in the replication or remodeling of certain heterochromatic regions

Mouse (Murine) Chromosome 14 Open Reading Frame 169 (C14orf169) Interaktionspartner

  1. NO66 regulates bone formation, at least in part, via regulating the number of bone-forming cells and expression of multiple genes that are critical for these processes

  2. Data indicate that mesenchymal overexpression of nucleolar protein 66 (NO66) inhibits skeletal cell proliferation.

  3. propose that Osx (zeige SP7 Proteine) is a molecular switch for the formation of an active chromatin state during osteoblast differentiation, whereas NO66 helps gene repression through histone demethylation and/or formation of a repressor complex

C14orf169 + NO66 (C14orf169) Protein Überblick

Protein Überblick

Histone demethylase that specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Acts as a regulator of osteoblast differentiation via its interaction with sp7/osx by demethylating H3K4me and H3K36me, thereby inhibiting sp7/osx-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region (By similarity).

Genbezeichner und Symbole assoziert mit C14orf169

  • chromosome 14 open reading frame 169 (LOC453015)
  • chromosome 14 open reading frame 169 (Bm1_08415)
  • ribosomal oxygenase 1 (RIOX1)
  • chromosome 5 open reading frame, human C14orf169 (C5H14ORF169)
  • ribosomal oxygenase 1 (Riox1)
  • ribosomal oxygenase 1 (riox1)
  • C10H14orf169 Protein
  • C14orf169 Protein
  • im:7141580 Protein
  • LOC453015 Protein
  • MAPJD Protein
  • no66 Protein
  • ROX Protein

Bezeichner auf Proteinebene für C14orf169

chromosome 14 open reading frame 169 , bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66 , histone lysine demethylase NO66 , lysine-specific demethylase NO66 , myc-associated protein with JmjC domain , nucleolar protein 66 , 60S ribosomal protein L8 histidine hydroxylase , MYC-associated protein with JmjC domain , hsNO66 , ribosomal oxygenase NO66 , myc associated protein with JmjC domain , chromosome 14 open reading frame 169-like

GENE ID SPEZIES
453015 Pan troglodytes
6096611 Brugia malayi
100219109 Taeniopygia guttata
511031 Bos taurus
79697 Homo sapiens
423249 Gallus gallus
71952 Mus musculus
314300 Rattus norvegicus
560815 Danio rerio
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