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The protein encoded by CHDH is a choline dehydrogenase that localizes to the mitochondrion.
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The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (zeige CHRD Antikörper) and subsequent maintenance of dkk1b (zeige DKK1 Antikörper) expression levels.
Binding of CV2 (zeige BMPER Antikörper) to Chordin (zeige CHRD Antikörper) promotes BMP-2 (zeige BMP4 Antikörper) signaling.
Targeted knockdown of Sox17 (zeige SOX17 Antikörper) and Chd (zeige CHRD Antikörper) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (zeige LEFTY2 Antikörper), and heart and pancreas placement in the embryo.
Chl (zeige CHRDL2 Antikörper), like Chd (zeige CHRD Antikörper), dorsalizes embryos upon overexpression and is cleaved by BMP1 (zeige BMP1 Antikörper); loss-of-function experiments show Chl (zeige CHRDL2 Antikörper) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (zeige CHRD Antikörper) in forming the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
by regulating the expression of her5, the Bmp2b (zeige BMP4 Antikörper)/Chordin (zeige CHRD Antikörper) gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Twisted (zeige POMT2 Antikörper) gastrulation enhances BMP signaling through chordin (zeige CHRD Antikörper) dependent and independent mechanisms
specification of anterior neural tissue requires later activities of Chordin (zeige CHRD Antikörper) and mesodermal factors.
CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous brains of bipolar disorder genome-wide association studies
In genotypic combination analysis considering PEMT (zeige PEMT Antikörper) -744GG/CHDH +432GG/BHMT (zeige BHMT Antikörper) +742GG as the reference combination, PEMT (zeige PEMT Antikörper) -744GC/CHDH +432GG/BHMT (zeige BHMT Antikörper) +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
CHDH is not a substrate of PARK2 (zeige PARK2 Antikörper) but interacts with SQSTM1 (zeige SQSTM1 Antikörper) independently of PARK2 (zeige PARK2 Antikörper) to recruit SQSTM1 (zeige SQSTM1 Antikörper) into depolarized mitochondria
the PEMT (zeige PEMT Antikörper) -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
CHDH and PLD2 (zeige PLD2 Antikörper) as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis.
CHDH A119C and MTHFR (zeige MTHFR Antikörper) C677T play an important role in modulating the homocysteine levels in Indian population.
HOXB13 (zeige HOXB13 Antikörper), IL17BR, and CHDH are regulated by estrogen in breast cancer
single nucleotide polymorphisms of choline-metabolizing genes, PEMT (zeige PEMT Antikörper) -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk
Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization).
Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date.
, dino (din)
, protein chordino
, choline dehydrogenase, mitochondrial
, choline dehydrogenase
, Choline dehydrogenase