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The protein encoded by CCR9 is a member of the beta chemokine receptor family.
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There were significantly increased CCR9 protein levels in failing human hearts.
this study showed that CCR7 (zeige CCR7 ELISA Kits) are overexpressed in CD4 (zeige CD4 ELISA Kits)(-) CD8 (zeige CD8A ELISA Kits)(-) thymocytes of myasthenia gravis patients.
Results indicated that the expression levels of CCR9 in lesional skin may be a useful biologic marker of the clinical efficacy of infliximab therapy in psoriasis patients.
Xray crystal structure of the CCR9 receptor in complex with vercirnon at 2.8 A resolution
that CCL25 (zeige CCL25 ELISA Kits)/CCR9 signal may provide cancer cells with chemotactic abilities through influencing several epithelial-mesenchymal transitionmarkers
Studies indicate important roles played by chemokine ligand 25 (CCL25 (zeige CCL25 ELISA Kits))/chemokine receptor 9 (CCR9) in tumorigenesis, tumor chemoresistance and metastasis.
CCR9 and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue.
CCR9 mRNA and protein levels were significantly increased in the nasopharyngeal carcinoma group compared with the control group.
CCR9-CCL25 (zeige CCL25 ELISA Kits) interaction promoted proliferation and suppressed apoptosis of non-small cell lung cancer cells by activating the PI3K (zeige PIK3CA ELISA Kits)/Akt (zeige AKT1 ELISA Kits) pathway.
CCR9 could be beneficial in predicting lymph node metastasis, and it might act as a novel prognostic biomarker for lung adenocarcinoma.
these results showed a site- and cell-specific expressions of Ccl25 (zeige CCL25 ELISA Kits) and its receptor Ccr9 within both maternal and embryonic compartments of implantation sites and suggested a role in inducing specific Ccr9+ leukocytes at the maternal-fetal interface during the initial steps of embryo implantation in the mouse model
Abrogation of CCR9 improved the post-myocardial infarction survival rate and left ventricular (LV) dysfunction and decreased the infarct size. The data reveal that CCR9 serves as a novel modulator of pathological progression following myocardial infarction through NF-kappaB (zeige NFKB1 ELISA Kits) and MAPK (zeige MAPK1 ELISA Kits) signaling.
Pressure overload-induced hypertrophy was greatly attenuated by CCR9 deficiency in cardiac-specific CCR9 knockout mice, whereas CCR9 overexpression in cardiac-specific transgenic mice strikingly enhanced cardiac hypertrophy.
CCR9 and CCL25 (zeige CCL25 ELISA Kits) expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process
data indicate that in addition to acting as a gut (zeige GUSB ELISA Kits)-homing molecule, CCR9 signaling shapes immune responses by inhibiting Treg cell development
Data suggest that blocking CC chemokine receptor 9 (CCR9) may represent a novel safe therapy for rheumatoid arthritis (RA).
activation of Notch1 (zeige NOTCH1 ELISA Kits) has a dominant-negative effect on Ccr9 transcription and that Notch1 (zeige NOTCH1 ELISA Kits) and E proteins control the dynamic expression of Ccr9 during T cell development.
CCR9/CCL25 (zeige CCL25 ELISA Kits) is involved in acute skin transplantation rejection and anti-CCL25 (zeige CCL25 ELISA Kits) strategies might be useful in preventing acute rejection.
Accumulated CD11b (zeige ITGAM ELISA Kits)(+) macrophages are critical for activating hepatic stellate cells through the CCR9/CCL25 (zeige CCL25 ELISA Kits) axis and therefore promote liver fibrosis.
The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene.
C-C chemokine receptor type 9
, G protein-coupled receptor 28
, C-C CKR-9
, chemokine C-C receptor 10
, chemokine C-C motif receptor 9