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CCL16 is one of several cytokine genes clustered on the q-arm of chromosome 17.
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Human Monoclonal CCL16 Primary Antibody für CyTOF, ELISA (Capture) - ABIN4899781
Cappello, Caorsi, Bosticardo, De Angelis, Novelli, Forni, Giovarelli: CCL16/LEC powerfully triggers effector and antigen-presenting functions of macrophages and enhances T cell cytotoxicity. in Journal of leukocyte biology 2004
Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine (zeige CCL1 Antikörper) ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma.
High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction.
Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS.
Low umbilical cord blood chemokine (zeige CCL1 Antikörper) CCL16 associates with spontaneous preterm birth
Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity.
An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice.
CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils.
CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.
small inducible cytokine A16
, C-C motif chemokine 16
, IL-10-inducible chemokine
, chemokine CC-4
, chemokine LEC
, liver CC chemokine-1
, liver-expressed chemokine
, lymphocyte and monocyte chemoattractant
, new CC chemokine 4
, small inducible cytokine subfamily A (Cys-Cys), member 16
, small-inducible cytokine A16