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CCL15 is located in a cluster of similar genes in the same region of chromosome 17.
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CCL15 secreted from SMAD4 (zeige SMAD4 ELISA Kits)-deficient xenografted human colorectal cancer cells recruited CCR1(+) cells, promoting their metastatic activities to the lung. Lung metastases from colorectal cancer patients revealed that CCL15 expression correlated with loss of SMAD4 (zeige SMAD4 ELISA Kits). CCL15-positive metastases recruited approximately 1.9 times more numbers of CCR1(+) cells than CCL15-negative metastases.
CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis.
Orthotopic animal models of HCC were established to investigate the role of CCL15 in hMSCs migration toward HCC in vivo. Both histological and flow cytometric analysis showed that significantly fewer hMSCs localized within 97H-CCL15-shRNA xenografts compared with 97H-green fluorescent protein xenografts after intravenous delivery
Loss of SMAD4 (zeige SMAD4 ELISA Kits) was significantly associated with CCL15 expression.
follicular thyroid carcinoma (FTC) might induce tumor associated macrophages (TAMs) infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from follicular adenoma
two inflammatory cytokines, MIP (zeige TNPO1 ELISA Kits)-1delta and MIP-3alpha (zeige CCL20 ELISA Kits), are able to increase mesenchymal stromal cells migration in vitro
we investigated a role of CCL15 in upregulating ICAM-1 (zeige ICAM1 ELISA Kits) in endothelial cells
CCL15 is elevated in human asthma and correlates with disease severity .
Data show that Only three of these proteins EGF (zeige EGF ELISA Kits), PDGF (zeige PDGFA ELISA Kits)-BB and MIP (zeige TNPO1 ELISA Kits)-1delta (CCL15) differed significantly in plasma between controls and Alzheimer's disease (AD).
PKCdelta (zeige PKCd ELISA Kits) activation due to Lkn-1 is involved in migration, as well as the butyric acid-induced differentiation.
This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14).
C-C motif chemokine 15
, chemokine CC-2
, leukotactin 1
, macrophage inflammatory protein 5
, new CC chemokine 3
, small inducible cytokine subfamily A (Cys-Cys), member 15
, small-inducible cytokine A15