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The protein encoded by XCR1 is a chemokine receptor belonging to the G protein-coupled receptor superfamily. Zusätzlich bieten wir Ihnen XCR1 Antikörper (90) und XCR1 Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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The distribution characters of cattle XCR1 and XCL1 (zeige XCL1 Proteine) suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 (zeige XCL1 Proteine) fused antigens.
The complete cDNA sequence of XCR1 was obtained, containing 415 bp 5'UTR, 1003 bp coding region and 248 bp 3'UTR.
TLR3 (zeige TLR3 Proteine)-responsive, XCR1+, CD141(BDCA-3 (zeige THBD Proteine))+/CD8alpha+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques.
Our study provides the basis for further investigation of the molecular mechanism by which down-regulation of XCR1 promotes the development and progression of HCC (zeige FAM126A Proteine).
Demonstrate equivalence between human and mouse XCR1(+) dendritic cells and human and mouse Langerhans cells.
results indicate that XCR1 is a new potential therapeutic target for the treatment of lung cancer bone metastasis
Induction of potent CD8 (zeige CD8A Proteine) T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.
XCR1 is expressed early during the course of tumorigenic transformation and contributes towards increased cell migration and proliferation, which can facilitate the prometastatic behavior of epithelial ovarian cancer cells.
CD8alpha-positive dendritic cells (DCs) and CD103 (zeige ITGAE Proteine)-positive DCs belong to a common DC subset which is unequivocally identified by XCR1 transgene expression despite their different anatomical locations.
Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility
XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow.
The expression patterns of XCR1 and XCL1 (zeige XCL1 Proteine) were conserved in human and mice blood cells, including certain dendritic cell subsets.
CD141 (zeige THBD Proteine)+ dendritic cells are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 (zeige XCL1 Proteine) by Ca2 (zeige CA2 Proteine)+ mobilization and potent chemotaxis.
The interaction between XCL1 (zeige XCL1 Proteine) and XCR1 plays a crucial role in the classical immunology response.
Data show that mice lacking either XCL1 (zeige XCL1 Proteine) or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 (zeige XCL1 Proteine) axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway.
Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8 (zeige CD8A Proteine)+ T-cell responses against influenza virus.
XCR1 constitutes the first conserved specific marker for cell subsets homologous to mouse CD8alpha+ dendritic cells in higher vertebrates.
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
chemokine XC receptor 1
, chemokine C motif receptor 1
, CCXC chemokine receptor 1 like
, XC chemokine receptor 1
, chemokine (C motif) receptor 1
, G protein-coupled receptor 5
, G-protein coupled receptor 5
, chemokine (C motif) XC receptor 1
, lymphotactin receptor
, C motif-1/lymphotactin receptor
, SCM1 receptor