Chemokine (C Motif) Receptor 1 Proteine (XCR1)

Cow (Bovine) Chemokine (C Motif) Receptor 1 (XCR1) Interaktionspartner

1. The distribution characters of cattle XCR1 and XCL1 (zeige XCL1 Proteine) suggested a vital role in regulation of acquired immune responses and indicated a potential for a DC targeted veterinary vaccine in cattle using XCL1 (zeige XCL1 Proteine) fused antigens.

Rhesus Monkey Chemokine (C Motif) Receptor 1 (XCR1) Interaktionspartner

1. The complete cDNA sequence of XCR1 was obtained, containing 415 bp 5'UTR, 1003 bp coding region and 248 bp 3'UTR.

2. TLR3 (zeige TLR3 Proteine)-responsive, XCR1+, CD141(BDCA-3 (zeige THBD Proteine))+/CD8alpha+-equivalent dendritic cells uncovered in healthy and simian immunodeficiency virus-infected rhesus macaques.

Human Chemokine (C Motif) Receptor 1 (XCR1) Interaktionspartner

1. Our study provides the basis for further investigation of the molecular mechanism by which down-regulation of XCR1 promotes the development and progression of HCC (zeige FAM126A Proteine).

2. Demonstrate equivalence between human and mouse XCR1(+) dendritic cells and human and mouse Langerhans cells.

3. results indicate that XCR1 is a new potential therapeutic target for the treatment of lung cancer bone metastasis

4. Induction of potent CD8 (zeige CD8A Proteine) T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.

5. XCR1 is expressed early during the course of tumorigenic transformation and contributes towards increased cell migration and proliferation, which can facilitate the prometastatic behavior of epithelial ovarian cancer cells.

6. CD8alpha-positive dendritic cells (DCs) and CD103 (zeige ITGAE Proteine)-positive DCs belong to a common DC subset which is unequivocally identified by XCR1 transgene expression despite their different anatomical locations.

7. Our findings argue against the hypothesis that genetic variability in the G-Protein-Coupled Receptor Kinase 5 and Casein Kinase 2 genes modifies Parkinson disease susceptibility

8. XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow.

9. The expression patterns of XCR1 and XCL1 (zeige XCL1 Proteine) were conserved in human and mice blood cells, including certain dendritic cell subsets.

10. CD141 (zeige THBD Proteine)+ dendritic cells are the only cells in human blood that express the chemokine receptor XCR1 and respond to the specific ligand XCL1 (zeige XCL1 Proteine) by Ca2 (zeige CA2 Proteine)+ mobilization and potent chemotaxis.

Mouse (Murine) Chemokine (C Motif) Receptor 1 (XCR1) Interaktionspartner

1. The interaction between XCL1 (zeige XCL1 Proteine) and XCR1 plays a crucial role in the classical immunology response.

2. Data show that mice lacking either XCL1 (zeige XCL1 Proteine) or XCR1 exhibit similar specific defects in intestinal T cell populations as XCR1-dendritic cells (DC)-deficient mice. Therefore it is possible that the XCR1-XCL1 (zeige XCL1 Proteine) axis itself is directly involved in intestinal T cell homeostasis, via a mechanism that might either involve interaction with XCR1+ DCs or be independent of this pathway.

3. Demonstrate equivalence between human and mouse XCR1(+) dendritic cells and human and mouse Langerhans cells.

4. Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8 (zeige CD8A Proteine)+ T-cell responses against influenza virus.

5. Induction of potent CD8 (zeige CD8A Proteine) T cell cytotoxicity by specific targeting of antigen to cross-presenting dendritic cells in vivo via murine or human XCR1.

6. The expression patterns of XCR1 and XCL1 (zeige XCL1 Proteine) were conserved in human and mice blood cells, including certain dendritic cell subsets.

7. XCR1 constitutes the first conserved specific marker for cell subsets homologous to mouse CD8alpha+ dendritic cells in higher vertebrates.