anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Antikörper

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Zusätzlich bieten wir Ihnen Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CHFR 231600 Q810L3
CHFR 55743 Q96EP1
CHFR 288734  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antikörper auf antikoerper-online.de

Showing 10 out of 69 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB CHFR Antibody (C-term) (ABIN658352) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the CHFR antibody detected the CHFR protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN184918 (2.5µg/ml) staining of paraffin embedded human brain (cerebellum). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA ABIN249757 (2.5ug/ml) staining of paraffin embedded Human Brain (Cerebellum). Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Fledermaus Ziege Unkonjugiert IHC (p), ELISA 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Human Kaninchen Unkonjugiert WB WB Image Sample(30 μg of whole cell lysate) A:H1299 7.5% SDS PAGE antibody diluted at 1:1000 WB Image CHFR antibody detects CHFR protein by western blot analysis. Whole cell extracts (30 μg) was separated by 7.5 % SDS-PAGE, and blotted with CHFR antibody , diluted by 1:500 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Maus Unkonjugiert IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to CHFR on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 2 ug/ml] Western blot analysis of CHFR over-expressed 293 cell line, cotransfected with CHFR Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CHFR monoclonal antibody (M01), clone 1H3-A12. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Meerschweinchen Kaninchen Unkonjugiert IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$676.50
Details
Human Kaninchen Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details
Human Ziege Unkonjugiert IHC, ELISA 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details

CHFR Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine) ,
,

Human ,
, ,
,
, , , , ,
Rat (Rattus) ,
,

Am meisten referenzierte anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Antikörper

  1. Human Monoclonal CHFR Primary Antibody für IHC (p), RNAi - ABIN565913 : Milne, Sitarz, Carvalho, Polak, Ligtenberg, Pauwels, Offerhaus, Weterman: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. in Human pathology 2007 (PubMed)
    Show all 7 Pubmed References

  2. Human Polyclonal CHFR Primary Antibody für IHC (p), IHC - ABIN249757 : Scolnick, Halazonetis: Chfr defines a mitotic stress checkpoint that delays entry into metaphase. in Nature 2000 (PubMed)

Weitere Antikörper gegen Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase Interaktionspartner

Mouse (Murine) Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Interaktionspartner

  1. CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells.

  2. The interaction between CHFR and PARP-1 (zeige PARP1 Antikörper) plays an important role in cell cycle regulation and cancer therapeutic strategies.

  3. CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.

  4. RNF8 (zeige RNF8 Antikörper) and Chfr, function together to activate ATM (zeige ATM Antikörper) and maintain genomic stability in vivo.

  5. Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.

  6. PML bodies control the distribution, dynamics and function of CHFR

  7. Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A (zeige AURKA Antikörper).

  8. Mice with deficiencies in both Chfr and Mlh1 (zeige MLH1 Antikörper) (the gene that encodes the DNA mismatch-repair protein Mlh1 (zeige MLH1 Antikörper)) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes.

Human Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Interaktionspartner

  1. Re-expression of CHFR in miR (zeige MLXIP Antikörper)-26a overexpressing cells partially rescues normal mitosis and impairs the tumorigenesis exerted by miR (zeige MLXIP Antikörper)-26a.

  2. Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia (zeige BCL11A Antikörper), is associated with adverse outcome, and can thus be used for risk stratification.

  3. Small molecule inhibition of CHFR-PARP1 (zeige PARP1 Antikörper) interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer.

  4. CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer.

  5. CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer

  6. CHFR promoter methylation is associated with colorectal cancer.

  7. CHFR-PAX5 (zeige PAX5 Antikörper) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.

  8. Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL (zeige RTEL1 Antikörper)), which might be a novel molecular marker as prognosis and treatment for B-NHL (zeige RTEL1 Antikörper).

  9. Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker.

  10. CHFR ubiquitinates and regulates TOPK (zeige PBK Antikörper) levels, which is essential for its checkpoint function.

Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Antigen-Profil

Protein Überblick

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).

Genbezeichner und Symbole assoziert mit CHFR

  • checkpoint with forkhead and ring finger domains (Chfr) Antikörper
  • checkpoint with forkhead and ring finger domains (CHFR) Antikörper
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase (chfr) Antikörper
  • checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase L homeolog (chfr.L) Antikörper
  • 5730484M20Rik Antikörper
  • C230082M18 Antikörper
  • fc43f10 Antikörper
  • RNF116 Antikörper
  • RNF196 Antikörper
  • si:dkey-69h6.7 Antikörper
  • wu:fc43f10 Antikörper

Bezeichner auf Proteinebene für CHFR

E3 ubiquitin-protein ligase CHFR , checkpoint with forkhead and RING finger domains protein , RING finger protein 196 , Checkpoint with forkhead and RING finger domains protein

GENE ID SPEZIES
231600 Mus musculus
55743 Homo sapiens
100154400 Sus scrofa
614816 Bos taurus
288734 Rattus norvegicus
564271 Danio rerio
734287 Xenopus laevis
477434 Canis lupus familiaris
100171543 Pongo abelii
Ausgewählte Anbieter für anti-Checkpoint with Forkhead and Ring Finger Domains, E3 Ubiquitin Protein Ligase (CHFR) Antikörper
Haben Sie etwas anderes gesucht?