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E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons.
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Human Monoclonal CHFR Primary Antibody für IHC (p), RNAi - ABIN565913
Milne, Sitarz, Carvalho, Polak, Ligtenberg, Pauwels, Offerhaus, Weterman: Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. in Human pathology 2007
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Human Polyclonal CHFR Primary Antibody für IHC (p), IHC - ABIN249757
Scolnick, Halazonetis: Chfr defines a mitotic stress checkpoint that delays entry into metaphase. in Nature 2000
CHFR is important for the survival of male premeiotic germ cells, which is likely through maintaining genomic stability in spermatogonial stem cells.
The interaction between CHFR and PARP-1 (zeige PARP1 Antikörper) plays an important role in cell cycle regulation and cancer therapeutic strategies.
CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.
RNF8 (zeige RNF8 Antikörper) and Chfr, function together to activate ATM (zeige ATM Antikörper) and maintain genomic stability in vivo.
Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.
PML bodies control the distribution, dynamics and function of CHFR
Downregulation of Chfr contributes to tumorigenesis by controlling the expression levels of Aurora A (zeige AURKA Antikörper).
Mice with deficiencies in both Chfr and Mlh1 (zeige MLH1 Antikörper) (the gene that encodes the DNA mismatch-repair protein Mlh1 (zeige MLH1 Antikörper)) displayed dramatically higher incidence of spontaneous tumors relative to mice deficient for only one of these genes.
JNK (zeige MAPK8 Antikörper) inhibitor prevents SIRT1 (zeige SIRT1 Antikörper) phosphorylation, leading to elevated SIRT1 (zeige SIRT1 Antikörper) protein levels even in the presence of H2O2. Taken together, our results indicate that CHFR plays a crucial role in the cellular stress response pathway by controlling the stability and function of SIRT1 (zeige SIRT1 Antikörper).
Re-expression of CHFR in miR (zeige MLXIP Antikörper)-26a overexpressing cells partially rescues normal mitosis and impairs the tumorigenesis exerted by miR (zeige MLXIP Antikörper)-26a.
Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia (zeige BCL11A Antikörper), is associated with adverse outcome, and can thus be used for risk stratification.
Small molecule inhibition of CHFR-PARP1 (zeige PARP1 Antikörper) interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer.
CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer.
CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer
CHFR promoter methylation is associated with colorectal cancer.
CHFR-PAX5 (zeige PAX5 Antikörper) fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia.
Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL (zeige RTEL1 Antikörper)), which might be a novel molecular marker as prognosis and treatment for B-NHL (zeige RTEL1 Antikörper).
Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker.
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating ubc13-mms2 (ube2n-ube2v2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress (By similarity).
E3 ubiquitin-protein ligase CHFR
, checkpoint with forkhead and RING finger domains protein
, RING finger protein 196
, Checkpoint with forkhead and RING finger domains protein