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CBLL1 encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes.
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Human Polyclonal CBLL1 Primary Antibody für IHC (fro), IF - ABIN2192196
Fujita, Krause, Scheffner, Zechner, Leddy, Behrens, Sommer, Birchmeier: Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. in Nature cell biology 2002
These results suggest that stabilization of delta-catenin (zeige CTNND2 Antikörper) by Hakai is dependent on Src (zeige SRC Antikörper).
these observations suggest that the dimeric architecture of the HYB domain is essential for the phosphotyrosine-binding property of Hakai.
By lowering Hakai abundance, miR (zeige MLXIP Antikörper)-203 also reduces Hakai-regulated-cell division.
Hakai dimerization allows the formation of a phosphotyrosine-binding pocket that recognizes specific phosphorylated tyrosines and flanking acidic amino acids of Src (zeige SRC Antikörper) substrates, such as E-cadherin (zeige CDH1 Antikörper), cortactin (zeige CTTN Antikörper) and DOK1 (zeige DOK1 Antikörper).
Hakai mediates E-cadherin (zeige CDH1 Antikörper) ubiquitination and degradation triggered by Slit-Robo signaling during colorectal epithelial cell carcinogenesis.
Together, these data do not support a requirement for CBLL1 during flavivirus entry and rather suggest an essential role of the ubiquitin/proteasome pathway for flavivirus genome amplification.
Results suggest that Hakai is a novel corepressor of ERalpha (zeige ESR1 Antikörper) and may play a negative role in the development and progression of breast cancers.
Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment.
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
, Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1
, E-cadherin binding protein E7
, E3 ubiquitin-protein ligase Hakai
, RING finger protein 188
, c-Cbl-like protein 1
, casitas B-lineage lymphoma-transforming sequence-like protein 1