anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antikörper

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Zusätzlich bieten wir Ihnen Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Kits (7) und Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CBLB 326625 Q96EY8
CBLB 208650 Q3TTA7
CBLB    
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Top anti-Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Antikörper auf antikoerper-online.de

Showing 10 out of 78 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of CBLB Antibody (Center) (ABIN652612) in HL-60 cell line lysates (35 µg/lane). CBLB (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human testis tissue reacted with CBLB Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of CBLB Antibody (Center) in HL-60 cell line lysates (35ug/lane). CBLB (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: Hep G2 , 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of CBLB staining in human liver cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with Western blot analysis of CBLB expression in Jurkat (A), 293T (B), mouse spleen (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: CBLB Antibody [NBP1-49920] - Samples: Whole cell lysate (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Cbl-b antibody NBP1-49920 used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. Cbl-b was also immunoprecipitated by rabbit anti-Cbl-b antibody NBP1-49919, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 minutes (A and B). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), IP Immunohistochemistry-Paraffin: CBLB Antibody [NBP1-49919] - Sample: FFPE section of human ovarian carcinoma. Antibody was used at a dilution of 1:1,000 (1ug/ml). Detection: DAB Immunoprecipitation: CBLB Antibody [NBP1-49919] - Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Cbl-b antibody NBP1-49919 used for IP at 3 ug/mg lysate. Cbl-b was also immunoprecipitated by rabbit anti-Cbl-b antibody NBP1-49920, which recognizes a downstream epitope. For blotting immunoprecipitated Cbl-b, NBP1-49920 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-RNF56/CBLB Polyclonal Antibody, Unconjugated (ABIN760256) at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat lung labeled with Anti-RNF56 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Maus Kaninchen Unkonjugiert WB Mouse Cblb Antibody (C-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Cblb antibody detected the Cblb protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry-Paraffin: CBLB Antibody [NBP1-86599] - Immunohistochemical staining of human stomach shows strong positivity in Parietal cells. Immunocytochemistry/Immunofluorescence: CBLB Antibody [NBP1-86599] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: CBLB Antibody [NBP1-86601] - Staining of human kidney shows strong membranous and cytoplasmic positivity in cells in glomeruli. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details

CBLB Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Weitere Antikörper gegen Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Interaktionspartner

Human Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Interaktionspartner

  1. MMAB (zeige MMAB Antikörper) might be a target and potential biomarker of hepatotoxicity in EFV-induced liver toxicity

  2. These findings suggest that rs11066782 in KCTD10, rs11613718 in KCTD10 and rs11067233 in MMAB may contribute to the susceptibility of coronary heart disease by altering plasma HDL-C levels in Han Chinese.

  3. MMAB mutations, including one novel nonsense mutation (c.12 C>A [p.C4X]), were identified in all members of the cblB cohort.

  4. Pathogenicity of the human truncation mutant results from its inability to sequester AdoCbl for direct transfer to methylmalonyl-CoA mutase (zeige MUT Antikörper), resulting in holoenzyme formation.

  5. c.584G>A, c.349-1G>C, and c.290G>A mutations affect the splicing process of ATR.

  6. These data suggest MMAB (zeige MMAB Antikörper) is the most likely gene influencing high-density lipoprotein-cholesterol levels at MMAB (zeige MMAB Antikörper)-MVK (zeige MVK Antikörper) locus.

  7. Characterization of ligand-binding by MMAB (zeige MMAB Antikörper) provides insight into the mechanism of cobalamin adenosylation and the effect of patient mutations in the inherited disorder

  8. report the identification of ATR cDNA as well as the corresponding gene; ATR expression is altered in cell lines derived from cblB methylmalonyl aciduria patients; propose that inborn errors in the ATR gene identified here result in methylmalonyl aciduria

  9. Results describe two common polymorphic variants of ATP:cob(I)alamin adenosyltransferase (zeige MMAB Antikörper) that are found in normal individuals, and their interactions with methionine synthase reductase (zeige MTRR Antikörper).

  10. Mutations in methylmalonic aciduria type B protein (zeige MMAB Antikörper) is associated with methylmalonic acidemia

Mouse (Murine) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Interaktionspartner

  1. GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. Constitutive activation of PKB in vivo results in a loss of tolerance that is mediated through the downregulation of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b.

  2. These studies reveal a novel, cell-autonomous requirement of CBL (zeige CBL Antikörper) and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR (zeige FRAP1 Antikörper) signaling.

  3. CBLB directs polyubiquitination of dectin-1 (zeige CLEC7A Antikörper) and dectin-2 (zeige CLEC6A Antikörper), two key pattern-recognition receptors for sensing Candida albicans, and their downstream kinase SYK (zeige SYK Antikörper), thus inhibiting dectin-1 (zeige CLEC7A Antikörper)- and dectin-2 (zeige CLEC6A Antikörper)-mediated innate immune responses.

  4. CBLB controls proximal C-type lectin receptor signaling in macrophages and dendritic cells. CBLB associates with SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. CBLB deficiency results in increased inflammasome activation, enhanced reactive oxygen species production, and increased fungal killing.

  5. study indicates that Cbl-b negatively regulates CLR (zeige CALCR Antikörper)-mediated antifungal innate immunity

  6. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl (zeige CBL Antikörper)-b deficiency-driven murine model of myeloproliferative disorders.

  7. Mechanistically, NFATc1 (zeige NFATC1 Antikörper) induces Nur77 (zeige NR4A1 Antikörper) expression at late stage of osteoclast differentiation; in turn, Nur77 (zeige NR4A1 Antikörper) transcriptionally up-regulates E3 ubiquitin ligase (zeige MUL1 Antikörper) Cbl-b, which triggers NFATc1 (zeige NFATC1 Antikörper) protein degradation.

  8. Silencing Cbl-b significantly enhanced T lymphocyte function and T lymphocyte cytotoxicity activity

  9. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  10. SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Antigen-Profil

Protein Überblick

This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found.

Genbezeichner und Symbole assoziert mit CBLB

  • methylmalonic aciduria (cobalamin deficiency) cblB type (MMAB) Antikörper
  • Casitas B-lineage lymphoma b (Cblb) Antikörper
  • AI429560 Antikörper
  • AI851073 Antikörper
  • ATR Antikörper
  • Cbl-b Antikörper
  • cblB Antikörper
  • cob Antikörper

Bezeichner auf Proteinebene für CBLB

ATP:cob(I)alamin adenosyltransferase , ATP:corrinoid adenosyltransferase , aquocob(I)alamin vitamin B12s adenosyltransferase , cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial , methylmalonic aciduria type B protein , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B

GENE ID SPEZIES
326625 Homo sapiens
208650 Mus musculus
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