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Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Zusätzlich bieten wir Ihnen Cation Channel, Sperm Associated 3 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
PMID: 12646162 concludes Alu repeats interfere with splicing of DCOHM and CAVL such that transcripts containing exons of both genes exist.
Data suggest that Catsper1, Catsper2, Catsper3, and Catsper4 form protein multimer with hypothetical activities of flippase and disulfide isomerase.
Hydrogen peroxide induced upregulation of catsper3 in brain.
CATSPER3 is a cation-channel protein and has role in acrosome reaction and male fertility
Catsper3 and Catsper4 knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
Data show that spinal cord injury doesn't significantly change the expression of CatSpers 3.
Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone.
cation channel, sperm associated 3
, cation channel sperm-associated protein 3
, cation channel sperm-associated protein 3-like
, ca(v)-like protein
, calcium channel repeat containing 1
, one-repeat calcium channel-like protein
, putative ion channel CatSper3