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Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation.
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Catsper3 has a single channel-forming domain, a pore-loop with the consensus sequence TxDxW, & a coiled-coil protein-protein interaction domain in the C-terminal tail. CatSpers 1,2,3 & 4 may interact directly or indirectly to form a functional tetramer.
PMID: 12646162 concludes Alu repeats interfere with splicing of DCOHM (zeige PCBD2 Antikörper) and CAVL such that transcripts containing exons of both genes exist.
Hydrogen peroxide induced upregulation of catsper3 in brain.
CATSPER3 is a cation-channel (zeige TRPV1 Antikörper) protein and has role in acrosome reaction and male fertility
Catsper3 and Catsper4 (zeige CATSPER4 Antikörper) knockout male mice are completely infertile due to a quick loss of motility and a lack of hyperactivated motility under capacitating conditions.
Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone.
cation channel, sperm associated 3
, cation channel sperm-associated protein 3
, cation channel sperm-associated protein 3-like
, ca(v)-like protein
, calcium channel repeat containing 1
, one-repeat calcium channel-like protein
, putative ion channel CatSper3