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CARD6 encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions.
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these data indicated that CARD6 serves as a novel cardioprotective factor via negative regulation of MEK kinase-1 (zeige MAP3K1 ELISA Kits)-dependent MEK (zeige MDK ELISA Kits)-ERK1/2 (zeige MAPK1/3 ELISA Kits) and JNK1 (zeige MAPK8 ELISA Kits)/2 signaling
CARD6 is a regulator of NF-kappaB (zeige NFKB1 ELISA Kits) activation that modulates the functions of RICK protein
Data show that NOD-like receptor signaling genes NOD2 (zeige NOD2 ELISA Kits), PYCARD (zeige PYCARD ELISA Kits), CARD6, and IFI16 (zeige IFI16 ELISA Kits) are upregulated in psoriatic epidermis.
The increased expression of CARD6 in esophageal squamous cell carcinoma,gastric and colorectal adenocarcinoma suggested that neoexpression of CARD6 might be related to activation of NF-kappaB (zeige NFKB1 ELISA Kits) pathway.
identification as a modulator of NF-kappa B (zeige NFKB1 ELISA Kits) activation by Nod1 (zeige NOD1 ELISA Kits)- and Cardiak-mediated pathways
review of the regulation of interactions of CARD6 with RICK and microtubules [review]
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
caspase recruitment domain family, member 6
, caspase recruitment domain-containing protein 6
, caspase recruitment domain-containing protein 6-like
, CARD-containing inhibitor of Nod1 and Cardiak-induced NF-kB activation
, caspase recruitment domain protein 6