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CASP14 encodes a member of the cysteine-aspartic acid protease (caspase) family.
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Human CASP14 ELISA Kit für Sandwich ELISA - ABIN415001
Jung, Choi, Lee, Kim, Hwang, Choi: Pyrrolidone carboxylic acid levels or caspase-14 expression in the corneocytes of lesional skin correlates with clinical severity, skin barrier function and lesional inflammation in atopic dermatitis. in Journal of dermatological science 2014
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Mesotrypsin (zeige PRSS3 ELISA Kits) generated saposins A-D from prosaposin (zeige PSAP ELISA Kits), and mature caspase-14 contributed to this process by activating mesotrypsinogen (zeige PRSS3 ELISA Kits) to mesotrypsin (zeige PRSS3 ELISA Kits). Knockdown of these proteases markedly down-regulated saposin A synthesis in skin equivalent models.
caspase-14 overexpression is not the cause of utricle formation
Caspase-14-deficient mice are more prone to the development of parakeratosis.
Mere impairment of filaggrin (zeige FLG ELISA Kits) degradation by loss of caspase 14 does not influence the inflammatory threshold of atopic dermatitis.
Caspase-14 is required for filaggrin (zeige FLG ELISA Kits) degradation to natural moisturizing factors in the skin.
Transcript profiling studies identified caspase (zeige GATA3 ELISA Kits)-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation (zeige GATA3 ELISA Kits) and tumorigenesis.
We investigated whether cardiac autonomic control is impaired during sleep in ob/ob mice with morbid obesity caused by congenital leptin (zeige LEP ELISA Kits) deficiency.
processing of caspase 14 in epidermal differentiation
SH2-B (zeige SH2B1 ELISA Kits) dramatically enhanced leptin (zeige LEP ELISA Kits)-stimulated tyrosine phosphorylation of IRS1 (zeige IRS1 ELISA Kits) and IRS2 (zeige IRS2 ELISA Kits) in human and mouse cells (this is supposed to be a NEWENTRY for mice--SH2-B (zeige SH2B1 ELISA Kits)).
Caspase-14, but not caspase-3 (zeige CASP3 ELISA Kits) activation coincides temporally and spatially with embryonic KC differentiation, suggesting a role for caspase-14 in terminally differentiated KC.
High CASP14 expression is a marker of breast cancer aggressiveness in association with proliferation, TNBC phenotype, and cancer stemness.
overexpression of S100A7 (zeige S100A7 ELISA Kits) in A431 skin squamous carcinoma cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3 (zeige GATA3 ELISA Kits) and caspase-14
caspase-14 contributes to retinal pigment epithelium cell barrier disruption under hyperglycemic conditions.
Caspase-14 was decreased in inflammatory lesions compared to non-lesion in atopic dermatitis. The amount of caspase-14 in the lesions correlated with clinical severity as determined by eczema area and severity index score and the skin barrier functions.
partial loss of caspase 14 is not associated with dedifferentiation in neoplastic lesions of the oral mucosa
genetic polymorphisms in AICDA (zeige AICDA ELISA Kits) and CASP14 are associated with risk for brain tumor in Korean children.
Suggest caspase-14 is a marker of human skin differentiation during development.
Results suggest that caspase-14 may interact with GCM1 to participate in syncytiotrophoblast differentiation during placental development.
ceramides, an important structural lipid, stimulate caspase-14 expression, coordinating formation of lipid lamellar membranes with the formation of corneocytes
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier.
, apoptosis-related cysteine protease
, caspase 14, apoptosis-related cysteine protease