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Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. Zusätzlich bieten wir Ihnen CBR3 Proteine (12) und CBR3 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CBR3 Primary Antibody für ELISA, WB - ABIN268608
Bains, Karkling, Lubieniecka, Grigliatti, Reid, Riggs: Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. in The Journal of pharmacology and experimental therapeutics 2010
Show all 2 Pubmed References
No significant correlation between cardiotoxicity and SNPs within the CBR (zeige CBR1 Antikörper) pathway. Further investigation into CBR (zeige CBR1 Antikörper) SNPs in a larger adult sample is needed.
association of SNPs in ABCB1 (zeige ABCB1 Antikörper) and CBR3 with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Variants of CBR3 and GSTP1 (zeige GSTP1 Antikörper) enzymes may be associated with changes in short-term functional cardiac parameters.
genetic polymorphism in the CBR3 gene conferred risk of type 2 diabetes and insulin (zeige INS Antikörper) resistance in Chinese. The association was probably mediated through modulation of adipogenesis.
CBR3 polymorphisms contribute to increased cardiomyopathy risk associated with anthracycline treatment of childhood cancer.
CBR3 is a novel target gene of inflammatory stimuli; elucidation of its detailed role in inflammation deserves further investigation.
Computational searches identify a conserved antioxidant response element(ARE) in the distal carbonyl reductase 3 (CBR3) promoter region.
The CBR3 distal promoter contains an activating cis (zeige CISH Antikörper)-regulatory element that is responsive to Trichostatin A (TSA (zeige PRDX2 Antikörper)) treatment according to promoter reporter assays in HEK (zeige EPHA3 Antikörper) 293 cells.
a physiological role of CBR1 (zeige CBR1 Antikörper), but not for CBR3, in S-nitrosoglutathione reduction and thus ultimately in regulation of NO signaling
CBR3 is regulated via NRF2 (zeige GABPA Antikörper)-dependent signaling pathways, a finding and plays an important role in the cellular response to oxidative stress.
Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
carbonyl reductase 3
, NADPH-dependent carbonyl reductase 3
, carbonyl reductase (NADPH) 3
, carbonyl reductase [NADPH] 3
, short chain dehydrogenase/reductase family 21C, member 2