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Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Zusätzlich bieten wir Ihnen Calpain 7 Antikörper (18) und viele weitere Produktgruppen zu diesem Protein an.
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The proteolytic activity of CAPN7 is important for the acceleration of EGFR (zeige EGFR Proteine) degradation via the endosomal sorting pathway.
Data indicate that CAPN 7 promotes endometrial stromal cell (hESC) migration and invasion by increasing the activity of MMP-2 (zeige MMP2 Proteine) via an increased ratio of MMP-2 (zeige MMP2 Proteine) to TIMP-2 (zeige TIMP2 Proteine).
Mutational analysis of calpain-7 reveals the importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity.
The detected enhancement of autolysis of mGFP-fused calpain-7 by coexpression with CHMP1B and observed further activation by additional coexpression of IST1 (zeige IST1 Proteine) in HEK293T cells.
Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1 (zeige IST1 Proteine).
calpain-derived Htt (zeige HTT Proteine) fragmentation has a role in Huntington's disease and aberrant activation of calpains may play a role in HD pathogenesis
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity.
, calpain like protease
, homolog of Aspergillus Nidulans PALB
, palB homolog