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Calcyphosine-2 is a calcium-binding protein with 2 EF-hand motifs (Wang et al., 2002 [PubMed 11846421]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen Calcyphosine 2 Antikörper (36) und Calcyphosine 2 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicate that LRRK2 (zeige LRRK2 ELISA Kits) and alpha-synuclein participate in the dysregulation of CADPS2 (zeige CADPS2 ELISA Kits) by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.
Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2 (zeige CADPS2 ELISA Kits)/D2DR (zeige DRD2 ELISA Kits) interaction.
We speculate that haploinsufficiency of CADPS2 (zeige CADPS2 ELISA Kits) contributes to ASDs.
identification, cloning, and comparative characterization of a second mammalian CAPS (zeige CAPS ELISA Kits) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (zeige CAPS ELISA Kits)
Results from Cadps2 (zeige CADPS2 ELISA Kits)-deficient mice and human data suggest that a disturbance in CADPS2 (zeige CADPS2 ELISA Kits)-mediated neurotrophin (zeige BDNF ELISA Kits) release contributes to autistic-like cellular and behavioral phenotypes.
CAPS proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2
These results suggest that Caps2 (zeige CADPS2 ELISA Kits) KO mice have altered endocrine responses to CORT (zeige CORT ELISA Kits) administration, while maintaining CORT (zeige CORT ELISA Kits)-induced anxiety/depressive-like behavior.
Naturally occurring splice variants of CAPS2 (zeige CADPS2 ELISA Kits) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (zeige CADPS2 ELISA Kits) primes vesicles independently of its MUN domain.
possible association of the dense-core vesicle secretion-related gene,CAPS2 (zeige CADPS2 ELISA Kits) with autism specturum disorder. (review)
CAPS (zeige CAPS ELISA Kits) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
CAPS2 (zeige CADPS2 ELISA Kits) promotes activity-dependent brain-derived neurotrophic factor (zeige BDNF ELISA Kits) secretion during the postnatal period that is critical for the development of hippocampal GABAergic networks.
CAPS2 (zeige CADPS2 ELISA Kits) KO mice will be a useful animal model to study the aspects of the neuropathology and behavior characteristics of neurodevelopmental disorders
These results demonstrate that the CAPS (zeige CAPS ELISA Kits) family proteins are involved in the secretion of different secretory substances in developing and postnatal brains, and that CAPS2 (zeige CADPS2 ELISA Kits) is probably involved in BDNF (zeige BDNF ELISA Kits) secretion in many brain areas.
CAPS2 (zeige CADPS2 ELISA Kits)-mediated neurotrophin (zeige BDNF ELISA Kits) release is indispensable for normal cerebellar development and functions, including neuronal differentiation and survival, morphogenesis, synaptic function, and motor learning/control.
In mouse, there are six splicing variants of CAPS2 (zeige CADPS2 ELISA Kits) (CAPS2a-f), and that these are subdivided into two groups: a long form containing the C-terminal Munc13-1 (zeige UNC13A ELISA Kits)-homologous domain (MHD) and a short form lacking the C-terminal MHD.
Data demonstrate that CAPS-1 (zeige CADPS ELISA Kits) and -2 generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2 (zeige CA2 ELISA Kits)+) triggered release of transmitters.
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
, calcyphosphine 2
, calcyphosin 2
, calcyphosine 2
, Ca2+-dependent activator protein for secretion 2
, calcium-dependent activator protein for secretion 2
, calcium-dependent secretion activator 2