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The protein encoded by CACNG8 is a type I transmembrane AMPA receptor regulatory protein (TARP). Zusätzlich bieten wir Ihnen CACNG8 Antikörper (30) und und viele weitere Produktgruppen zu diesem Protein an.
Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 (zeige KCNN3 ELISA Kits) and KCNJ2 (zeige KCNJ2 ELISA Kits) Genes and CACNG8-Linked Left Ventricular Dysfunction
these findings demonstrate that TARPgamma-8 is a crucial mediator of CaMKII (zeige CAMK2G ELISA Kits)-dependent Long Term Potentiation and therefore a molecular target that controls synaptic plasticity and associated cognitive functions.
TARP gamma-8 is the only TARP expressed at nonperforated type of pyramidal cell synapses, playing an essential role in low-density or basal AMPAR expression
This study demonstrated that genetic inactivation of this specific population of AMPA (zeige GRIA3 ELISA Kits) receptors results in modest changes in behavior characterized by a mild hyperactivity.
coexpression of both auxiliary subunits,CKAMP44 and TARP gamma-8 is necessary for the efficient targeting of AMPARs to the cell surface of dentate gyrus granule cells
The results of thia study suggested that there are distinct TARP-dependent mechanisms for synaptic transmission and long term potential.
Tarp gamma-8 (and CNIH-2 (zeige CNIH2 ELISA Kits)) functionally interact with common AMPA (zeige GRIA3 ELISA Kits) receptor complexes in hippocampus; however, TARP gamma-8-containing hippocampal neurons do not display resensitization.
Previously uncharacterized roles for the TARP intracellular N terminus, loop, and C terminus in modulating both the trafficking and gating of synaptic AMPARs, are reported.
Discusses evidence for non-AUG translation start codon for Cacng8.
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon.
calcium channel, voltage-dependent, gamma subunit 8
, voltage-dependent calcium channel gamma-8 subunit
, TARP gamma-8
, neuronal voltage-gated calcium channel gamma-8 subunit
, transmembrane AMPAR regulatory protein gamma-8
, TARP gamma 8