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CACNA2D3 encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Zusätzlich bieten wir Ihnen CACNA2D3 Antikörper (31) und viele weitere Produktgruppen zu diesem Protein an.
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Nine of the 32 (28.1%) iCCA (zeige PRRT2 Proteine) patients had gene mutations at chromosome 3p, totaling 11 mutations across five genes. Those included five (15.6%) BAP1 (zeige RNF2 Proteine) mutations, two each (6.3%) of CACNA2D3 and RASSF1 (zeige RASSF1 Proteine) mutations, and one each (3.1%) of ATG7 (zeige ATG7 Proteine) and PLCD1 (zeige PLCD1 Proteine) mutations. Six (18.8%) cases had concurrent loss of chromosome 3p and gene mutations.
Findings demonstrate the tumor suppressive role of CACNA2D3 in gliomas. CACNA2D3 operates via Ca 2thorn signaling and the activation of non-canonical Wnt (zeige WNT2 Proteine) signaling to inhibit cell proliferation and motility and induce apoptosis.
The risk of developing anaemia is increased in reproductive age women carriers of A allele of rs1868505 (CACNA2D3) and/or T allele of rs13194491 (HIST1H2BJ).
CACNA2D3-mediated increase in intracellular calcium (Ca2 (zeige CA2 Proteine)+) can induce mitochondrial-mediated apoptosis.
CACNA2D3 is a novel tumor suppressor gene responsible for the 3p21 deletion event that plays a critical suppressing role in the development and progression of esophageal squamous cell carcinoma.
CACNA2D3 polymorphism rs1375515 plays important role in iron status and is associated with the levels of iron-related biomarkers, as well as with iron clinical phenotypes (normal, iron de fi cient and anaemic).
Expression of CACNA2D3 mRNA is regulated in breast cancer cell lines by methylation in the CpG island located in the 5' regulatory region of the gene.
High CACNA2D3 gene expression is assiciated with glioblastoma multiforme.
In humans, study found single-nucleotide polymorphisms in alpha2delta3 that are associated with reduced acute heat pain sensitivity in healthy volunteers and chronic postsurgical back pain.
did not detect submicroscopic deletion or duplication nor sequence alteration in either CACNA2D3 or WNT5A (zeige WNT5A Proteine) in ZLS-affected individuals
our results identify a novel role for the alpha2delta3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.
Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) exhibit impaired behavioral heat pain sensitivity.
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
calcium channel, voltage-dependent, alpha 2/delta 3 subunit
, voltage-dependent calcium channel subunit alpha-2/delta-3
, calcium channel, voltage-dependent, alpha 2/delta subunit 3
, calcium channel, voltage-dependent, alpha 2/delta 3 subunit-like
, voltage-dependent calcium channel subunit alpha-2/delta-3-like
, calcium channel alpha2-delta3 subunit
, voltage-gated calcium channel subunit alpha-2/delta-3
, alpha 2 delta-3
, calcium channel, voltage dependent, alpha2/delta subunit 3