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The protein encoded by CIB2 is similar to that of KIP/CIB, calcineurin B, and calmodulin.
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this study identifies CIB1 (zeige CIB1 ELISA Kits) and CIB2 as host helper factors for HIV-1 replication that are required for optimal receptor-mediated viral entry
results suggest that GJB2 (zeige GJB2 ELISA Kits) and CIB2 are common cause of hearing loss in different Pakistani ethnicities
High CIB2 expression is associated with ovarian Cancer.
We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity.
CIB2 (Calcium and Integrin Binding Protein (zeige CIB1 ELISA Kits) 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family
Data indicate that that CIB2 localizes to stereocilia and interacts with the USH proteins myosin VIIa and whirlin (zeige DFNB31 ELISA Kits), suggesting CIB2 is a Ca2 (zeige CA2 ELISA Kits)+-buffering protein essential for calcium homeostasis in the mechanosensory stereocilia of inner ear hair cells.
Consistent with molecular modeling predictions of calcium binding, CIB2 significantly decreased the ATP-induced calcium responses in heterologous cells, whereas mutations in deafness DFNB48 altered CIB2 effects on calcium responses
CIB2, as binding partners for the integrin alphaIIb subunit, which suggests that they are potentially involved in regulating integrin alphaIIb subunit activation.
This study showed that calcium and integrin-binding protein (zeige CIB1 ELISA Kits) 2 binds to the components of the hair cell mechanotransduction complex, TMC1 (zeige TMC1 ELISA Kits) and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations.
Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy
The protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a calcium-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunits (DNA-PKcs). Several transcript variants encoding different isoforms have been found for this gene.
, DNA-dependent protein kinase catalytic subunit-interacting protein 2
, KIP 2
, Usher syndrome 1J (autosomal recessive)
, calcium and integrin-binding family member 2
, calcium binding protein Kip 2
, calcium binding protein Kip2
, kinase interacting protein 2
, kinase-interacting protein 2