CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 Proteine (CTDP1)

CTDP1 encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Zusätzlich bieten wir Ihnen CTDP1 Antikörper (43) und CTDP1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte CTDP1 CTDP1 291414  
CTDP1 9150 Q9Y5B0
CTDP1 67655 Q7TSG2
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
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Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$414.29
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Hefe Encephalitozoon cuniculi His tag   1 mg 60 bis 71 Tage
$3,142.33
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CTDP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1) Interaktionspartnern

Human CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1) Interaktionspartner

  1. Study identifies CTDP1 as an autoantigen specific for Behcet Disease.

  2. results demonstrated that CTDP1 was upregulated in human lung cancer tissues. In addition, it implied that CTDP1 played an important role in cell proliferation and may be a useful therapeutic target in human lung cancer.

  3. Data propose that Fcp1 has a crucial role in the liaison between dephosphorylation and ubiquitination that drives mitosis exit.

  4. although FCP1 is intrinsically disordered, the above 16 residues composing the RAP74 binding surface form nascent alpha-helical structure in the unbound state.

  5. NMR assignments for C terminal region

  6. FCP1 augments tat transactivation of the HIV-1 long-terminal repeat

  7. FCP1 is important for transcription elongation along with TFIIF

  8. FCP1 binds to a groove of RAP74 between alpha-helices H2 and H3, without affecting the secondary structure of RAP74 C-terminal domain; FCP1 binds also to a groove of TFIIB core domain beween alpha helices D1 and E1 in the first cyclin repeat.

  9. FCP1 kinase from HeLa cells is phosphorylated and affects transcription elongation

  10. cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1

  11. high-resolution solution structure of a cterRAP74cterFCP complex by NMR spectroscopy

  12. Congenital cataracts facial dysmorphism neuropathy is caused by a single-nucleotide substitution in an antisense Alu element in intron 6 of CTDP1, resulting in a rare mechanism of aberrant splicing and an Alu insertion in the processed mRNA

  13. found that FCP1 is a genuine substrate of PRMT5-methylation both in vivo and in vitro, and FCP1-associated PRMT5 can methylate histones H4 in vitro

  14. Enhanced binding to RAP74 following phosphorylation.

  15. These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression, production of BMP-4 and activation of BMP signaling.

  16. NMR and thermodynamic studies further elucidate the complex molecular mechanism by which TFIIF and FCP1 cooperate for RNAPII recycling.

CTDP1 Protein Überblick

Protein Überblick

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit CTDP1

  • CTD phosphatase subunit 1 (Ctdp1)
  • CTD phosphatase subunit 1 (CTDP1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (ctdp1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1)
  • RNA polymerase II subunit A C-terminal domain phosphatase (ANI_1_2668024)
  • RNA polymerase II subunit A C-terminal domain phosphatase (AOR_1_1228154)
  • RNA polymerase II subunit A C-terminal domain phosphatase (CpipJ_CPIJ004583)
  • RNA polymerase II subunit A C-terminal domain phosphatase (PTRG_11566)
  • CTD phosphatase Fcp1 (SJAG_01286)
  • RNA polymerase II subunit A C-terminal domain phosphatase (MCYG_05528)
  • RNA polymerase II subunit A C-terminal domain phosphatase (VDBG_09811)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (Ctdp1)
  • 4930563P03Rik Protein
  • AW553592 Protein
  • CCFDN Protein
  • CTDP1 Protein
  • FCP1 Protein

Bezeichner auf Proteinebene für CTDP1

RNA polymerase II subunit A C-terminal domain phosphatase , CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 , RNA polymerase II subunit A C-terminal domain phosphatase-like , CTD of POLR2A, phosphatase of, subunit 1 , TFIIF-associating CTD phosphatase 1 , serine phosphatase FCP1a , transcription factor IIF-associating CTD phosphatase 1 , CTD (carboxy-terminal domina, RNA polymerase II, polypeptide A) phosphatase, subunit 1 , TFIIF-associating CTD phosphatase

GENE ID SPEZIES
291414 Rattus norvegicus
420813 Gallus gallus
442930 Danio rerio
468592 Pan troglodytes
476158 Canis lupus familiaris
519011 Bos taurus
698467 Macaca mulatta
4979212 Aspergillus niger CBS 513.88
5991827 Aspergillus oryzae RIB40
6036281 Culex quinquefasciatus
6349883 Pyrenophora tritici-repentis Pt-1C-BFP
7052361 Schizosaccharomyces japonicus yFS275
9224666 Arthroderma otae CBS 113480
9528922 Verticillium alfalfae VaMs.102
100065422 Equus caballus
100158188 Sus scrofa
100222208 Taeniopygia guttata
100405913 Callithrix jacchus
9150 Homo sapiens
67655 Mus musculus
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