CNDP Dipeptidase 2 (Metallopeptidase M20 Family) Proteine (CNDP2)

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003 [PubMed 12473676]).[supplied by OMIM, Mar 2008]..

alle Proteine anzeigen Gen GeneID UniProt
Ratte CNDP2 CNDP2 291394 Q6Q0N1
Maus CNDP2 CNDP2 66054 Q9D1A2
Human CNDP2 CNDP2 55748 Q96KP4
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
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Baculovirus infected Insect Cells Maus His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$437.80
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Baculovirus infected Insect Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$206.80
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,336.67
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,336.67
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Hefe Orang-Utan His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,336.67
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Weitere Proteine zu CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2) Interaktionspartnern

Mouse (Murine) CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2) Interaktionspartner

  1. These results provide evidence showing that intradimer interaction of H228 with the reaction center of the dimer counterpart is essential to the enzymatic activity of Cn2.

  2. These findings suggest that the transduced PEP-1-PRX2 (zeige PRRX2 Proteine) has neuroprotective functions against oxidative stress-induced (zeige SQSTM1 Proteine) cell death in vitro and in vivo

  3. Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.

Human CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2) Interaktionspartner

  1. The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 (zeige CNDP1 Proteine) rs2346061, and CNDP1 (zeige CNDP1 Proteine) rs2887) were overrepresented in power athletes compared with nonathletes.

  2. These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form.

  3. To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5 (zeige ABCC5 Proteine)), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation.

  4. Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo.

  5. Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) pathway.

  6. a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation.

  7. deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer.

  8. Common variants in CNDP1 (zeige CNDP1 Proteine) and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes.

  9. the crystal structure of the flop-selective allosteric modulator, PEPA, bound to the binding domains of the GluA2 (zeige GRIA2 Proteine) and GluA3 (zeige GRIA3 Proteine) flop isoforms of AMPA (zeige GRIA3 Proteine) receptors

  10. Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 (zeige CNDP1 Proteine) genomic region and susceptibility for diabetic nephropathy in type 1 diabetes

Maize/Corn (Zea mays) CNDP Dipeptidase 2 (Metallopeptidase M20 Family) (CNDP2) Interaktionspartner

  1. Transgenic rice plants over-expressing the maize C4-pepc (zeige PEPCK Proteine) gene encoding phosphoenolpyruvate carboxylase (zeige PEPCK Proteine) (PC) and wild-type (WT) rice plants were subjected to PEG (zeige PAEP Proteine) 6000 treatments to simulate drought stress. Compared with WT, PC had the higher survival rate and net photosynthetic rate after 16days of drought treatment, and had higher relative water content in leaves after 2h of drought treatment as well.

  2. PEPC (zeige PEPCK Proteine) can improve both stress tolerance and grain yield in wheat.

CNDP2 Protein Überblick

Protein Überblick

CNDP2, also known as tissue carnosinase and peptidase A (EC 3.4.13.18), is a nonspecific dipeptidase rather than a selective carnosinase (Teufel et al., 2003

Genbezeichner und Symbole assoziert mit CNDP2

  • carnosine dipeptidase 2 (Cndp2)
  • CNDP dipeptidase 2 (metallopeptidase M20 family) (Cndp2)
  • CNDP dipeptidase 2 (metallopeptidase M20 family) (CNDP2)
  • carnosine dipeptidase 2 (CNDP2)
  • CNDP dipeptidase 2 (metallopeptidase M20 family) (cndp2)
  • carnosine dipeptidase 2 (cndp2)
  • CNDP dipeptidase 2 (metallopeptidase M20 family) S homeolog (cndp2.S)
  • CNDP dipeptidase 2 (metallopeptidase M20 family) L homeolog (cndp2.L)
  • phosphoenolpyruvate carboxylase 1 (pep1)
  • 0610010E05Rik Protein
  • C76600 Protein
  • cn2 Protein
  • CNDP2 Protein
  • cndp2b Protein
  • cpgl Protein
  • darmin-r Protein
  • Dip-2 Protein
  • HsT2298 Protein
  • Pep-1 Protein
  • Pep1 Protein
  • PEPA Protein
  • pepc Protein
  • PEPC1 Protein
  • PEPCase Protein
  • PPC1 Protein
  • PPEPC4 Protein
  • wu:fd20d11 Protein
  • wu:fe17f09 Protein
  • zgc:92569 Protein

Bezeichner auf Proteinebene für CNDP2

cytosolic non-specific dipeptidase , cytosolic nonspecific dipeptidase 2 , cytosolic nonspecific dipeptidase , glutamate carboxypeptidase-like protein 1 , peptidase 1 , peptidase A , CNDP dipeptidase 2 , CNDP dipeptidase 2 (metallopeptidase M20 family) , CNDP dipeptidase 2 b , CNDP dipeptidase 2 (metallopeptidase M20 family) b , CNDP dipeptidase 2 a , P-pyruvate carboxylase , PEP carboxylase , PEPCase 1 , phosphoenolpyruvate carboxylase 1

GENE ID SPEZIES
291394 Rattus norvegicus
66054 Mus musculus
421013 Gallus gallus
55748 Homo sapiens
695080 Macaca mulatta
394907 Xenopus (Silurana) tropicalis
476166 Canis lupus familiaris
100174694 Pongo abelii
512626 Bos taurus
327288 Danio rerio
380001 Xenopus laevis
446978 Xenopus laevis
100061697 Equus caballus
100347984 Oryctolagus cuniculus
542372 Zea mays
100735444 Cavia porcellus
100158127 Sus scrofa
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